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Doth the plot thicken even further?

Posted: Mon Oct 06, 2025 5:27 pm
by biopearl123
Date of patent August 26,2025:

United States Patent
Gryaznov et al.
(54) GUANINE ANALOGS AS TELOMERASE
SUBSTRATES AND TELOMERE LENGTH
AFFECTORS
(71) Applicant: Geron Corporation, Foster City, CA
(US)
(72) Inventors: Sergei M. Gryaznov, San Mateo, CA
(US); Ronald A. Pruzan, P'alo Alto,
CA (US); Kristina Pongracz,
Oakland, CA (US)
(73) Assignee: Geron Corporation, Foster City, CA
(US)
(*) Notice: Subject to any disclaimer, the term of this
patent is extended or adjusted under

Sergei of course is at MAIA

I was taken to task by some when I suggested that at least some of MAIAs IP might still be intertwined with Geron

Re: Doth the plot thicken even further?

Posted: Mon Oct 06, 2025 6:15 pm
by seedylemon
This is great news, biopearl.
The rights to the patent are transferred to Geron, giving credit to Sergei as inventor. Looks like we're still best buds.

Re: Doth the plot thicken even further?

Posted: Mon Oct 06, 2025 6:53 pm
by biopearl123
Seedylemon, truth is I dont have the IP sophistication to understand the full significance, but i think its good!

Re: Doth the plot thicken even further?

Posted: Mon Oct 06, 2025 6:53 pm
by biopearl123
Maybe HI could weigh in.

Re: Doth the plot thicken even further?

Posted: Thu Oct 16, 2025 6:55 am
by biopearl123
These agents apparently could be administered orally.

Re: Doth the plot thicken even further?

Posted: Thu Oct 16, 2025 5:16 pm
by biopearl123
6 thio DG is a guanine analog. It can be administered orally or by other routes. Could this and other variants be the oral agent Dr. Scarlett alluded to? Anyone with knowledge of patents invited to comment.

Re: Doth the plot thicken even further?

Posted: Fri Oct 17, 2025 8:37 pm
by biopearl123
Looks like Geron could buy MAIA for (and return Sergei to the fold?) for about 42M.