Good Vibes
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- Comments must be civil and on topic
- Back up claims with evidence/reasoning/sources (posting links is allowed)
- No commercials/harassment/spam
Re: Good Vibes
Time to take this old dog behind the shed and put it out of it's misery........ enough already!! -Kmall
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biopearl123
- Posts: 2591
- Joined: Fri Jul 20, 2018 5:13 pm
Re: Good Vibes
LWS, I refer you to the LCTX web site.
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LWS
Re: Good Vibes
bp -- I took your suggestion, and this is what I found. I believe potential cancer vaccines, VAC2, and Rytelo's role (if any) are legitimate subjects for this board. Are there still any benefits to Geron, if LCTX is successful?
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Lineage Cell (LCTX) Upgraded to Strong Buy: What Does It Mean for the Stock?
Zacks Equity Research
Thu, January 30, 2025 at 12:00 PM EST
In This Article:
LCTX
+3.98%
Lineage Cell (LCTX) appears an attractive pick, as it has been recently upgraded to a Zacks Rank #1 (Strong Buy). An upward trend in earnings estimates -- one of the most powerful forces impacting stock prices -- has triggered this rating change.
The Zacks rating relies solely on a company's changing earnings picture. It tracks EPS estimates for the current and following years from the sell-side analysts covering the stock through a consensus measure -- the Zacks Consensus Estimate.
Individual investors often find it hard to make decisions based on rating upgrades by Wall Street analysts, since these are mostly driven by subjective factors that are hard to see and measure in real time. In these situations, the Zacks rating system comes in handy because of the power of a changing earnings picture in determining near-term stock price movements.
Therefore, the Zacks rating upgrade for Lineage Cell basically reflects positivity about its earnings outlook that could translate into buying pressure and an increase in its stock price.
Most Powerful Force Impacting Stock Prices
The change in a company's future earnings potential, as reflected in earnings estimate revisions, has proven to be strongly correlated with the near-term price movement of its stock. That's partly because of the influence of institutional investors that use earnings and earnings estimates for calculating the fair value of a company's shares. An increase or decrease in earnings estimates in their valuation models simply results in higher or lower fair value for a stock, and institutional investors typically buy or sell it. Their transaction of large amounts of shares then leads to price movement for the stock.
Fundamentally speaking, rising earnings estimates and the consequent rating upgrade for Lineage Cell imply an improvement in the company's underlying business. Investors should show their appreciation for this improving business trend by pushing the stock higher.
===========
Lineage Cell Therapeutics Inc and Cancer Research UK revealed primary and secondary endpoint results from the recently completed clinical study of VAC2 in advanced non-small cell lung cancer (NSCLC).
The Phase 1 study was designed to investigate safety, immunogenicity, and survival in patients with advanced NSCLC when administered the allogeneic dendritic cell (DC) vaccine VAC2.
VAC2 DC cells have been engineered to present hTERT, a tumor-associated antigen found almost exclusively in cancer cells, and it is postulated that VAC2 will stimulate an immunogenic anti-tumor CD4+/CD8+ T cell response toward hTERT expressed on tumor cells.
Also Read: EXCLUSIVE: Lineage Cell Inks Exclusive Agreement For Novel Cell-Based Therapies With Potential In Neurology.
================
Lineage Cell (LCTX) Upgraded to Strong Buy: What Does It Mean for the Stock?
Zacks Equity Research
Thu, January 30, 2025 at 12:00 PM EST
In This Article:
LCTX
+3.98%
Lineage Cell (LCTX) appears an attractive pick, as it has been recently upgraded to a Zacks Rank #1 (Strong Buy). An upward trend in earnings estimates -- one of the most powerful forces impacting stock prices -- has triggered this rating change.
The Zacks rating relies solely on a company's changing earnings picture. It tracks EPS estimates for the current and following years from the sell-side analysts covering the stock through a consensus measure -- the Zacks Consensus Estimate.
Individual investors often find it hard to make decisions based on rating upgrades by Wall Street analysts, since these are mostly driven by subjective factors that are hard to see and measure in real time. In these situations, the Zacks rating system comes in handy because of the power of a changing earnings picture in determining near-term stock price movements.
Therefore, the Zacks rating upgrade for Lineage Cell basically reflects positivity about its earnings outlook that could translate into buying pressure and an increase in its stock price.
Most Powerful Force Impacting Stock Prices
The change in a company's future earnings potential, as reflected in earnings estimate revisions, has proven to be strongly correlated with the near-term price movement of its stock. That's partly because of the influence of institutional investors that use earnings and earnings estimates for calculating the fair value of a company's shares. An increase or decrease in earnings estimates in their valuation models simply results in higher or lower fair value for a stock, and institutional investors typically buy or sell it. Their transaction of large amounts of shares then leads to price movement for the stock.
Fundamentally speaking, rising earnings estimates and the consequent rating upgrade for Lineage Cell imply an improvement in the company's underlying business. Investors should show their appreciation for this improving business trend by pushing the stock higher.
===========
Lineage Cell Therapeutics Inc and Cancer Research UK revealed primary and secondary endpoint results from the recently completed clinical study of VAC2 in advanced non-small cell lung cancer (NSCLC).
The Phase 1 study was designed to investigate safety, immunogenicity, and survival in patients with advanced NSCLC when administered the allogeneic dendritic cell (DC) vaccine VAC2.
VAC2 DC cells have been engineered to present hTERT, a tumor-associated antigen found almost exclusively in cancer cells, and it is postulated that VAC2 will stimulate an immunogenic anti-tumor CD4+/CD8+ T cell response toward hTERT expressed on tumor cells.
Also Read: EXCLUSIVE: Lineage Cell Inks Exclusive Agreement For Novel Cell-Based Therapies With Potential In Neurology.
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LWS
Re: Good Vibes
Here is an article that mentions telomerase, imetelstat (Rytelo), and vaccines in the abstract.
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This Article
Published in Advance September 30, 2024, doi: 10.1101/cshperspect.a041703
Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved
AbstractFree
» Full TextFree
Full Text (PDF)Free
All Versions of this Article:
cshperspect.a041703v1
16/12/a041703 most recent
---------------------------------
Telomerase in Cancer Therapeutics
Silvia Siteni1,2,
Anthony Grichuk1,2 and
Jerry W. Shay1
+
Author Affiliations
1University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, Texas 75390, USA
Correspondence: jerry.shay@utsouthwestern.edu
↵2 These authors contributed equally to this work.
Abstract
While silent in normal differentiated human tissues, telomerase is reactivated in most human cancers. Thus, telomerase is an almost universal oncology target. This update describes preclinical and clinical advancements using a variety of approaches to target telomerase. These include direct telomerase inhibitors, G-quadruplex DNA-interacting ligands, telomerase-based vaccine platforms, telomerase promoter-driven attenuated viruses, and telomerase-mediated telomere targeting approaches. While imetelstat has been recently approved by the Food and Drug Administration (FDA), several other approaches are in late-stage clinical development. The pros and cons of the major approaches will be reviewed.
https://cshperspectives.cshlp.org/conte ... 3.full.pdf
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jayfish101
- Posts: 331
- Joined: Tue Feb 23, 2016 5:48 pm
Re: Good Vibes
I asked AI to check for competitors for Imetelstat and there were about five, but none of them above preclinical phase. Sounds good.
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biopearl123
- Posts: 2591
- Joined: Fri Jul 20, 2018 5:13 pm
Re: Good Vibes
Jay, worth keeping an eye on pelabresib/rux combo studies
Re: Good Vibes
Preclinical and Clinical advancements are always exciting, but I’d say more exciting in the rear view mirror. I highly doubt any one investing in Geron or reading this board is pumped by potential advancements that may come in the upcoming years or decades.
I can barely wait another few weeks for European marketing authorization let alone years or decade(s). I’m struggling over here and I see the Institutions who now control the vast amount of the stock are (trying to) prey on that obvious retail / small fry sentiment. Not going to happen over here despite my beyond frayed nerves.
(And yes it is a correct notion that an inept and feckless, not believing in science administration leading the NIH, FDA etc will be a further setback if not worse… not sure why that such an opinion or statement should be forbidden when Super Dave, curb your enthusiasm ((a personal favorite)), and rock stars / music videos are so prolific. I say bring it all and people could read and respond to what they want.)
I can barely wait another few weeks for European marketing authorization let alone years or decade(s). I’m struggling over here and I see the Institutions who now control the vast amount of the stock are (trying to) prey on that obvious retail / small fry sentiment. Not going to happen over here despite my beyond frayed nerves.
(And yes it is a correct notion that an inept and feckless, not believing in science administration leading the NIH, FDA etc will be a further setback if not worse… not sure why that such an opinion or statement should be forbidden when Super Dave, curb your enthusiasm ((a personal favorite)), and rock stars / music videos are so prolific. I say bring it all and people could read and respond to what they want.)
LWS wrote: Sat Feb 01, 2025 4:46 pm
Here is an article that mentions telomerase, imetelstat (Rytelo), and vaccines in the abstract.
=============
This Article
Published in Advance September 30, 2024, doi: 10.1101/cshperspect.a041703
Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved
AbstractFree
» Full TextFree
Full Text (PDF)Free
All Versions of this Article:
cshperspect.a041703v1
16/12/a041703 most recent
---------------------------------
Telomerase in Cancer Therapeutics
Silvia Siteni1,2,
Anthony Grichuk1,2 and
Jerry W. Shay1
+
Author Affiliations
1University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, Texas 75390, USA
Correspondence: jerry.shay@utsouthwestern.edu
↵2 These authors contributed equally to this work.
Abstract
While silent in normal differentiated human tissues, telomerase is reactivated in most human cancers. Thus, telomerase is an almost universal oncology target. This update describes preclinical and clinical advancements using a variety of approaches to target telomerase. These include direct telomerase inhibitors, G-quadruplex DNA-interacting ligands, telomerase-based vaccine platforms, telomerase promoter-driven attenuated viruses, and telomerase-mediated telomere targeting approaches. While imetelstat has been recently approved by the Food and Drug Administration (FDA), several other approaches are in late-stage clinical development. The pros and cons of the major approaches will be reviewed.
https://cshperspectives.cshlp.org/conte ... 3.full.pdf
Re: Good Vibes
Bp - correct, that was actually mentioned yesterday in his "don't screw us thread"......
"In December, pelabresib met its late-stage primary study goal and all four hallmarks of disease in myelofibrosis, when used in combination with ruxolitinib....."
As far as AI is concerned, not exactly a reliable source of information. It misses quite a bit. Perhaps a decent starting point if you feel the need, but there are other therapies targeting the same indications as Imetelstat, which are gaining traction in CT's.
I think one of Imetelstats most unique qualities will be in its abilities as a combination option. If you take a look at Keytruda (pembrolizumab) by Merck, about 2/3rds of its FDA approvals (there are 41 now) are in combination with other drugs - including ruxolitinib. This was a drug that was almost overlooked in its infancy and shelved. As a matter of fact, when it was in the hands of Schering Plough:
"Just when it seemed like the team was starting to gain momentum, Schering itself was acquired by Merck in 2009, initiating, of course, a new reprioritization process for the integrated companies. This time, the PD1 program was less fortunate, and the team was told to stop work. Yet, they persisted–in skunkworks fashion, variously pitching their work as an oncology project, an antiviral project and a vaccine enhancement project. Eventually, however, management caught on and formally shut down their work. The molecule was placed on the out-license list, and ultimately a term sheet was drafted setting the terms for a specific interested party to obtain rights to the molecule at what was said to be a negligible cost.
Everything changed, however, by the middle of 2010. First, BMS published in the New England Journal of Medicine (NEJM) a successful Phase III study in refractory metastatic melanoma involving ipilimumab (Yervoy), a drug targeting the different but related T-cell inhibitor molecule CTLA4, pointing to the potential efficacy of the so-called “checkpoint inhibitor” approach. Second, word began to filter through to Merck that nivolumab, or nivo (brand name: Opdivo), an earlier-stage molecule targeting PD1 that BMS also acquired though its recent acquisition of Medarex, was showing signs of promise."
https://www.forbes.com/sites/davidshayw ... ockbuster/
Keytruda brought in over $25B in global revenue last year to Merck, and is one of the most successful oncology drugs of all time.
https://www.fiercepharma.com/pharma/who ... -drug-2023
https://www.drugs.com/history/keytruda. ... A%20Yes%20(First%20approved,Tract%20Tumor%2C%20Malignant%20Pleural%20Mesothelioma
When Dr. Mascarenhas highlighted in last years ASH:
"This was a well-tolerated combination with no DLTs in patients with intermediate-1, intermediate-2, or high-risk myelofibrosis who were already on ruxolitinib,” Mascarenhas said in conclusion. “The 2 drugs in combination did not affect each other’s pharmacokinetic profiles, and there is some early evidence of efficacy in terms of spleen, symptom, and [possibly] mutational changes.”
That is a pretty BIG deal.........$25B/yr big?.......that we'll have to wait and see. -Kmall
"In December, pelabresib met its late-stage primary study goal and all four hallmarks of disease in myelofibrosis, when used in combination with ruxolitinib....."
As far as AI is concerned, not exactly a reliable source of information. It misses quite a bit. Perhaps a decent starting point if you feel the need, but there are other therapies targeting the same indications as Imetelstat, which are gaining traction in CT's.
I think one of Imetelstats most unique qualities will be in its abilities as a combination option. If you take a look at Keytruda (pembrolizumab) by Merck, about 2/3rds of its FDA approvals (there are 41 now) are in combination with other drugs - including ruxolitinib. This was a drug that was almost overlooked in its infancy and shelved. As a matter of fact, when it was in the hands of Schering Plough:
"Just when it seemed like the team was starting to gain momentum, Schering itself was acquired by Merck in 2009, initiating, of course, a new reprioritization process for the integrated companies. This time, the PD1 program was less fortunate, and the team was told to stop work. Yet, they persisted–in skunkworks fashion, variously pitching their work as an oncology project, an antiviral project and a vaccine enhancement project. Eventually, however, management caught on and formally shut down their work. The molecule was placed on the out-license list, and ultimately a term sheet was drafted setting the terms for a specific interested party to obtain rights to the molecule at what was said to be a negligible cost.
Everything changed, however, by the middle of 2010. First, BMS published in the New England Journal of Medicine (NEJM) a successful Phase III study in refractory metastatic melanoma involving ipilimumab (Yervoy), a drug targeting the different but related T-cell inhibitor molecule CTLA4, pointing to the potential efficacy of the so-called “checkpoint inhibitor” approach. Second, word began to filter through to Merck that nivolumab, or nivo (brand name: Opdivo), an earlier-stage molecule targeting PD1 that BMS also acquired though its recent acquisition of Medarex, was showing signs of promise."
https://www.forbes.com/sites/davidshayw ... ockbuster/
Keytruda brought in over $25B in global revenue last year to Merck, and is one of the most successful oncology drugs of all time.
https://www.fiercepharma.com/pharma/who ... -drug-2023
https://www.drugs.com/history/keytruda. ... A%20Yes%20(First%20approved,Tract%20Tumor%2C%20Malignant%20Pleural%20Mesothelioma
When Dr. Mascarenhas highlighted in last years ASH:
"This was a well-tolerated combination with no DLTs in patients with intermediate-1, intermediate-2, or high-risk myelofibrosis who were already on ruxolitinib,” Mascarenhas said in conclusion. “The 2 drugs in combination did not affect each other’s pharmacokinetic profiles, and there is some early evidence of efficacy in terms of spleen, symptom, and [possibly] mutational changes.”
That is a pretty BIG deal.........$25B/yr big?.......that we'll have to wait and see. -Kmall
Re: Good Vibes
Ryan - Engaging in political banter here will inevitably open up Pandora's box. I don't think anyone here wants to go the route of the YMB.
As far as Super Dave, rock videos or CYE being prolific, I question what you actually consider prolific since they have been sprinkled in for fun from time to time while we wait things out. And any of those has zero political motivations unlike your above statement. There are numerous articles starting to suggest quite the opposite. And I will add that perhaps ceasing Big Pharma from political influence and the FDA from allowing toxins in our food, amongst other things might not only benefit mankind in the long run, but also investors such as ourselves who have undoubtedly suffered from the weight of both BP and the FDA the past 15 years or longer. -Kmall
As far as Super Dave, rock videos or CYE being prolific, I question what you actually consider prolific since they have been sprinkled in for fun from time to time while we wait things out. And any of those has zero political motivations unlike your above statement. There are numerous articles starting to suggest quite the opposite. And I will add that perhaps ceasing Big Pharma from political influence and the FDA from allowing toxins in our food, amongst other things might not only benefit mankind in the long run, but also investors such as ourselves who have undoubtedly suffered from the weight of both BP and the FDA the past 15 years or longer. -Kmall
Re: Good Vibes
“Weirdest episode of Curb your Enthusiasm ever” lol
https://m.youtube.com/watch?v=a7MJP7zYhLQ
https://m.youtube.com/watch?v=a7MJP7zYhLQ
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LWS
Re: Good Vibes
It seems to me that this chatroom is primarily about Geron, Rytelo and related issues.
What can legitimately be discussed here as related issues? What is now happening in public health, at NIH, and at the FDA both with cancer research and potential cancer vaccines is now fully in focus and it affects everyone. It is now part of our history. There needs to be some practical limits, but there is no place to hide.
Who do you believe, me or your own lying eyes? from Groucho Marx
Question for Quote Investigator: According to legend when the wife of a famous comedian caught him in bed with another person the entertainer was unperturbed and denied that anything improper was occurring
What can legitimately be discussed here as related issues? What is now happening in public health, at NIH, and at the FDA both with cancer research and potential cancer vaccines is now fully in focus and it affects everyone. It is now part of our history. There needs to be some practical limits, but there is no place to hide.
Who do you believe, me or your own lying eyes? from Groucho Marx
Question for Quote Investigator: According to legend when the wife of a famous comedian caught him in bed with another person the entertainer was unperturbed and denied that anything improper was occurring
=============
To the chatroom --(And yes it is a correct notion that an inept and feckless, not believing in science administration leading the NIH, FDA etc will be a further setback if not worse… not sure why that such an opinion or statement should be forbidden when Super Dave, curb your enthusiasm ((a personal favorite)), and rock stars / music videos are so prolific. I say bring it all and people could read and respond to what they want.) --- from Ryan
To Ryan - Engaging in political banter here will inevitably open up Pandora's box. I don't think anyone here wants to go the route of the YMB. --- from Kmall
To bp — I had to lookup these words to read your message. I do believe what happens at NIH and the FDA will have a major impact on cancer research, including Rytelo research. Beyond that, we are all waiting for comments and conclusions involving European approvals. --- from LWS
Definition -- Myeloproliferative disorders include several different conditions that are characterized by excess production of blood cells in the body. They differ based on which type of blood cell is overproduced—red blood cells (carry oxygen from the lung to tissues), platelets (help the blood to clot), or white blood cells (help the body fight infection).
Last edited by LWS on Sun Feb 02, 2025 5:31 pm, edited 1 time in total.
Re: Good Vibes
LWS - You continue playing the political card on this board. I can assure you that I would easily trounce you in actual FACT over your lame stream media fictional accounts of the apocalypse nearing with a new appointment who is set to steam roll the corrupt status quo that has literally PIGEON holed this company into a tiny little box the past two decades. I am fully prepared to go toe to toe with you or anyone else interested in sparring actual FACT.
But in doing so, you MUST provide actual proof of your claims.
For starters, since you're so knowledgeable and have "sources" at the NIH, why not indulge to the board here on who Christine Grady is and why her position is questionable AT BEST, especially at this point considering her relationship to the Chief Medical Advisor for the President of The United States?
Try answering that in a coherent fashion, and please do so without resorting to rehashing old quotes. -Kmall
*I'll also add that by you and anyone else insisting on shading this board with political views when our gracious moderator has politely requested not doing so is EXTREMELY disrespectful to both him and all others who would like to see this board remain politically neutral.......there are many other forums to participate in if you feel the need to vent any frustrations....... I-Chat isn't it!!
But in doing so, you MUST provide actual proof of your claims.
For starters, since you're so knowledgeable and have "sources" at the NIH, why not indulge to the board here on who Christine Grady is and why her position is questionable AT BEST, especially at this point considering her relationship to the Chief Medical Advisor for the President of The United States?
Try answering that in a coherent fashion, and please do so without resorting to rehashing old quotes. -Kmall
*I'll also add that by you and anyone else insisting on shading this board with political views when our gracious moderator has politely requested not doing so is EXTREMELY disrespectful to both him and all others who would like to see this board remain politically neutral.......there are many other forums to participate in if you feel the need to vent any frustrations....... I-Chat isn't it!!
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LWS
Re: Good Vibes
Kmall --- I do not know Christine Grady. Why do you bring her into to this conversation?
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From Wikipedia
Career
Grady has worked in nursing, clinical research, and clinical care, with a specialization in HIV.[2] She was a Commissioner on the Presidential Commission for the Study of Bioethical Issues from 2010 and 2017.[2]
Grady is a member of the National Academy of Medicine, a senior fellow at the Kennedy Institute of Ethics, and a fellow of The Hastings Center and American Academy of Nursing.[2] She received the National Institutes of Health CEO Award in 2017 and the Director's Award from the same organization in 2015 and 2017.
Personal life
Grady is married to Anthony Fauci, an American immunologist and former head of the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health.[5][6] They have three daughters.[5]
====
From Wikipedia
Career
Grady has worked in nursing, clinical research, and clinical care, with a specialization in HIV.[2] She was a Commissioner on the Presidential Commission for the Study of Bioethical Issues from 2010 and 2017.[2]
Grady is a member of the National Academy of Medicine, a senior fellow at the Kennedy Institute of Ethics, and a fellow of The Hastings Center and American Academy of Nursing.[2] She received the National Institutes of Health CEO Award in 2017 and the Director's Award from the same organization in 2015 and 2017.
Personal life
Grady is married to Anthony Fauci, an American immunologist and former head of the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health.[5][6] They have three daughters.[5]
Re: Good Vibes
LWS - time to stop acting cute and man up. These are your words from Jan 27:
"I have been talking to some people I know at NIH. They are in complete panic about continuing cancer research programs both internally and externally,....."
http://imetelchat.imetelstat.eu/viewtop ... f=1&t=2208
You obviously have the ability to look up Christine Grady. She is a very important/powerful individual at the NIH. You are the one who keeps bringing up the NIH and dragging your slanted NON FACTUAL POLITICAL beliefs into conversations. You have mentioned this agency on numerous occasions lately, with your direct ties to individuals you are talking to there. You should have known who she was if you were that familiar with the inner workings of the NIH.
You CONVENIENTLY left out that Christine Grady is the head of the Department of Bioethics at NIH.
Now look at WHO she is married to, and try connecting some serious dots on why CONFLICT OF INTEREST may perhaps be an understatement.
These agencies are riddled with deep corruption. It's effecting Americans in more ways than many realize. You keep insisting on throwing your political views onto this board. It's disrespectful and pure misinformation at best. Try doing your homework for once. -Kmall
"I have been talking to some people I know at NIH. They are in complete panic about continuing cancer research programs both internally and externally,....."
http://imetelchat.imetelstat.eu/viewtop ... f=1&t=2208
You obviously have the ability to look up Christine Grady. She is a very important/powerful individual at the NIH. You are the one who keeps bringing up the NIH and dragging your slanted NON FACTUAL POLITICAL beliefs into conversations. You have mentioned this agency on numerous occasions lately, with your direct ties to individuals you are talking to there. You should have known who she was if you were that familiar with the inner workings of the NIH.
You CONVENIENTLY left out that Christine Grady is the head of the Department of Bioethics at NIH.
Now look at WHO she is married to, and try connecting some serious dots on why CONFLICT OF INTEREST may perhaps be an understatement.
These agencies are riddled with deep corruption. It's effecting Americans in more ways than many realize. You keep insisting on throwing your political views onto this board. It's disrespectful and pure misinformation at best. Try doing your homework for once. -Kmall
Re: Good Vibes
So now you want to talk politics?
Or do you want to once again hope that a widower is “taken out to the woodshed”??
Or will you once again ask someone who offends *your* sensibility to “meet you” somewhere to settle the score?
But you post links so you should be able to make these statements, while other are not able to… I suppose cause they don’t post enough links?? Or, you gonna call on others to ban people from the board, cause you don’t like their posts?
‘Animal Farm’ anyone … or, ok I know you like Rock & Roll…
“Stop Making Sense”
Man if GERN were at $6 these ‘conversations’ wouldn’t have digressed this far. Hopefully the European marketing authorization comes this week so some virtual chill pills will be delivered.
Or do you want to once again hope that a widower is “taken out to the woodshed”??
Or will you once again ask someone who offends *your* sensibility to “meet you” somewhere to settle the score?
But you post links so you should be able to make these statements, while other are not able to… I suppose cause they don’t post enough links?? Or, you gonna call on others to ban people from the board, cause you don’t like their posts?
‘Animal Farm’ anyone … or, ok I know you like Rock & Roll…
“Stop Making Sense”
Man if GERN were at $6 these ‘conversations’ wouldn’t have digressed this far. Hopefully the European marketing authorization comes this week so some virtual chill pills will be delivered.
Re: Good Vibes
Ryan - you can't be serious?
Unlike yourself, I haven't made ONE political statement on this board. Mentioning a Govt agency and employee of is not a POLITICAL statement. I simply mentioned her so that LWS was aware of who makes crucial decisions in that agency and the connections tied to that position. You seem to have a reading comprehension issue here.
No one is saying you can't have opposing views. Who stated that? Again, YOU are making something up.
The issue here are NON FACTUAL statements that are POLITICALLY motivated. Is that the purpose of this forum?
After Bp politely requested no politics on the board YOU threw this out yesterday:
"And yes it is a correct notion that an inept and feckless, not believing in science administration leading the NIH, FDA etc will be a further setback if not worse…"
Not only is the above statement completely unfounded, it's DISRESPECTFUL to the moderator after having asked to refrain from political views here.
A decent person would consider apologizing for continuing on with what is already on the verge of simply opinionated based hogwash.
Yes, try INCLUDING an actual link of a reliable source to back up claims. I believe that's part of the guidelines here. Otherwise these outlandish claims are MISINFORMATION. It helps to actually do your own homework Ryan.
And yes, I'll point something out if it's a load of rubbish, as I believe Bp does as well, although he is much more eloquent.
Now for the sake of this board it's time to give the Good Vibes thread a rest........it's nothing but BAD vibes lately. -Kmall
Unlike yourself, I haven't made ONE political statement on this board. Mentioning a Govt agency and employee of is not a POLITICAL statement. I simply mentioned her so that LWS was aware of who makes crucial decisions in that agency and the connections tied to that position. You seem to have a reading comprehension issue here.
No one is saying you can't have opposing views. Who stated that? Again, YOU are making something up.
The issue here are NON FACTUAL statements that are POLITICALLY motivated. Is that the purpose of this forum?
After Bp politely requested no politics on the board YOU threw this out yesterday:
"And yes it is a correct notion that an inept and feckless, not believing in science administration leading the NIH, FDA etc will be a further setback if not worse…"
Not only is the above statement completely unfounded, it's DISRESPECTFUL to the moderator after having asked to refrain from political views here.
A decent person would consider apologizing for continuing on with what is already on the verge of simply opinionated based hogwash.
Yes, try INCLUDING an actual link of a reliable source to back up claims. I believe that's part of the guidelines here. Otherwise these outlandish claims are MISINFORMATION. It helps to actually do your own homework Ryan.
And yes, I'll point something out if it's a load of rubbish, as I believe Bp does as well, although he is much more eloquent.
Now for the sake of this board it's time to give the Good Vibes thread a rest........it's nothing but BAD vibes lately. -Kmall
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LWS
Re: Good Vibes
bp (my thoughts for your comment) -- It appears that we have reached an impasse here. This is your chatroom to monitor and control. If you allow one side to post an opinion, please let the other side respond without fear of retribution. We are in unprecedented times, where current events and recent history are interacting in ways that we have never seen before. How are truth and facts to be defined when so many are operating under the cover of "big lies"? Unfortunately, it seems that we have to put some practical limits on how we communicate with each other.
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mistergern
- Posts: 221
- Joined: Sat Mar 19, 2016 3:48 pm
Re: Good Vibes
I think it is appropriate for LWS's concerns about the fate of the NIH and the FDA to be voiced on this forum. If other folks disagree with the facts he cites or his opinions they should feel free to express themselves as well.
Re: Good Vibes
Mistergern - the problem with your statement, with all due respect is one single word - FACTS.........he has none.....it's a politically motivated opinion.
"If other folks disagree with the facts he cites....."
Big difference between what is an actual fact and an opinion - and regardless, there is also a difference with a basic "concern" and a political statement.
Up until this point - with the exception of LWS and now Ryan yesterday, I have yet to read any other poster throw politics into the discussion here regarding any Govt agency.
If that's the way this board wants to continue, then I'll be more than happy to refrain from reading or participating here any longer. I just don't see how a political debate enhances this forum in any way, shape or form? -Kmall
"If other folks disagree with the facts he cites....."
Big difference between what is an actual fact and an opinion - and regardless, there is also a difference with a basic "concern" and a political statement.
Up until this point - with the exception of LWS and now Ryan yesterday, I have yet to read any other poster throw politics into the discussion here regarding any Govt agency.
If that's the way this board wants to continue, then I'll be more than happy to refrain from reading or participating here any longer. I just don't see how a political debate enhances this forum in any way, shape or form? -Kmall
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LWS
Re: Good Vibes
To all concerned (for comment):
I still believe that the vibes for Rytelo are good. If some of the items that I have posted seem to be political to some, it has been accidental. I apologize for that and will try to do better.
There seems to be a disagreement about what is political and what is not. I am very surprised at some of the comments about fact and opinion. As much as possible, I have documented what I have posted and have tried to separate facts from opinion. Sometimes there are disagreements about what are facts and what are not. Anything forward looking will have some element of opinion (possibilities & probabilities).
Here are some of the active subjects that are currently being discussed by me and others:
1. Rytelo (imetelstat) -- as is, new chemistry and new patents
2. Geron as a company -- earnings, leaders and possible partners or collaborators
3. Rytelo combinations
4. The FDA approvals
5. NIH and the FDA going forward
6. Pending approvals (EMA, EU, MHRA, etc.)
7. Rytelo as part of cancer vaccine research and as a supplement to chemotherapy
8. Blood cancer understanding as compared to other (solid) cancers
9. Potential competition and other approaches
10. KOLs, conferences, publications
I will use this list as a guide. I am prepared to be corrected when necessary, and do not take any criticism personally.
I still believe that the vibes for Rytelo are good. If some of the items that I have posted seem to be political to some, it has been accidental. I apologize for that and will try to do better.
There seems to be a disagreement about what is political and what is not. I am very surprised at some of the comments about fact and opinion. As much as possible, I have documented what I have posted and have tried to separate facts from opinion. Sometimes there are disagreements about what are facts and what are not. Anything forward looking will have some element of opinion (possibilities & probabilities).
Here are some of the active subjects that are currently being discussed by me and others:
1. Rytelo (imetelstat) -- as is, new chemistry and new patents
2. Geron as a company -- earnings, leaders and possible partners or collaborators
3. Rytelo combinations
4. The FDA approvals
5. NIH and the FDA going forward
6. Pending approvals (EMA, EU, MHRA, etc.)
7. Rytelo as part of cancer vaccine research and as a supplement to chemotherapy
8. Blood cancer understanding as compared to other (solid) cancers
9. Potential competition and other approaches
10. KOLs, conferences, publications
I will use this list as a guide. I am prepared to be corrected when necessary, and do not take any criticism personally.