ImetelChat

I think part of the problem is that the math sets this up to be a long trial. As a thought experiment, pretend all imetelstat patients live forever. We would never reach an interim analysis or a conclusion. With the interim analysis being triggered by 35% deaths and only 33% patients on placebo, we ...

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Why is GERN moving today?
$1.31 -0.12 (-8.39%)
Updated 3m ago
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Geron Corporation (GERN) fell 7% after disappointing trial results for its lead cancer drug, significantly underperforming the healthcare sector's minor decline of 0.38%
Market context: While the broader healthcare sector dipped 0 ...

Overall excellent article, except they didn't address the elephant in the room.... the long standing coordinated short attack on Geron. It's impossible to honestly attempt a comprehensive analysis of Geron past, present, and future without acknowledging the insidious short attack whose goal is to ...

DOH!

This just came out today, Nov 28, 2023.

https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/fda-investigating-serious-risk-t-cell-malignancy-following-bcma-directed-or-cd19-directed-autologous

JNJ dropped the CD with Geron largely because they believed Car-T was the future of cancer treatments. This is a sad turn ...

IMpress Phase 2 is an investigator-led study being led by The European Myelodysplastic Neoplasms Cooperative Group (EMSCO) and Australasian Leukaemia & Lymphoma Group (ALLG).

Does this mean the primary funding for this trial comes from EMSCO and ALLG? Of course, I would presume the Imetelstat is ...

@mck. I don't have any further details other than the link I provided in the 3rd post of this topic chain which opens the official EMA document which sanctions and approves the investigatory use of Imetelstat in children between the ages of 28 days and 18 years with MDS, JMML, and AML. I don't think ...

Sorry Biopearl. I didn't mean to suggest these trials are starting on Nov 13 2023 though I can see how my clumsy wording could be interpreted in that way. I meant to say these trials were officially approved in the EU by the EMA as of Nov 13, 2023.

@ kmall - I don't know the exact changes made which is why I haven't said anything. I suspect the changes were to include the indications of MDS, JMML, and AML. I think previously approved conditions for Imetelstat investigations in EU children were brain cancer (which I believe was revoked at some ...

Essentially, the EMA has adopted the proposed changes to the Pediatric Investigational Plan to allow a clinical trial for children with MDS, JMML and AML to commence as of Nov 13, 2023. The trial will have several stages where imetelstat is used in combination with 2 different chemotherapeutics and ...

Excellent point biopearl. Pediatric AML is a soul crushing form of cancer that gets a massive amount of media attention. We've all seen the pictures of little kids with bald heads in the news and research donation solicitations. If I'm reading these very early signs right, I think imetelstat may ...

https://www.ema.europa.eu/en/medicines/ ... p03-20-m01

Here is a link to the EMA Approval Document. Near the bottom just under the field "DECISION" is the pdf document that was adopted by the EMA on Nov 13, 2023.

Just today, Nov 13, 2023, the European Medicines Agency approved a modification to the Imetelstat Paediatric Investigation Plan to allow imetelstat to be administered to children between the ages of 28 days and 18 years with MDS, JMML, or AML. Why, and why now?

This comes out just on the heels of ...

A Salute to Memom (pronounced mee-mom)

A little over 6 ½ years ago, My Grandmother turned 90. In the spring of 2013, we had a huge family reunion for her to celebrate her 90s. Every single living descendant of hers with the exception of 1 grandchild was present to celebrate her 90th birthday ...

I Met Angels

We sure do have a strange way to conduct medical research! Ideally, medical science should be allowed to conduct true scientific research to find the most effective medical treatments and medicines without financial interests to dictate the priorities of the research. But here’s the ...

Imetelstat May Become a Blockbuster Drug by Being 2nd?!?

Abraham Lincoln became one of the most remembered and celebrated Presidents of the United States of America by being 2nd! Strange but true. You see, when Abraham Lincoln went to Chicago in May of 1860 for the Republican National Convention ...

Avalanche of Class-action Lawsuits Opened Against Geron.

Last Thursday’s class action lawsuit avalanche is obviously a coordinated attack on Geron designed by the short cabal to rattle investor faith in the company, and to force the company to waste time, energy, and resources on legal battles ...

“Title: Combination Treatment with Imetelstat, a Telomerase Inhibitor, and Ruxolitinib Depletes Myelofibrosis Hematopoietic Stem Cells and Progenitor Cells (Abstract #2963)
Session Name: 635. Myeloproliferative Syndromes: Basic Science: Poster II
Session Date: Sunday, December 8, 2019
Session Time ...

Greetings Imetelchat Community,

Here is a post of mine that was deleted from the Yahoo Message Board, but I polished it a little and cleaned up a couple parts to ensure compliance with the forum rules. Always take advantage of a 2nd chance! I hope it’s ok for me to share these thoughts and ...