I think a few things are clear now

[biopearl123]

1. The prolongation of mOS in the post 2019 Moffett data is not related to anything directly related to Imetelstat.
2. Imetelstat (or BAT Impact data) is not included in the mOS numbers, except as they relate to the updated 2016 data. The mOS numbers post 2019 are in no way contaminated by Imet effects.
3. The registry clearly starts with 27 patient who have failed Rux and are followed until death or censoring.
4. Censoring is required to remove patients who are entered into pathways that are not on the approved next therapies list.
5. Once a patient is censored that patient is removed from the denominator and no longer counted as a "patient at risk". This shrinks the denominator of the post 2019 pool to very small numbers that lead to a very wide confidence intervals. I speculate that many censored patients have left the registry for other studies (e.g.IMpact).
6. Trying to related the data from the 2019 curves to possible BAT curves in Impact is probably pointless.
7. It is not correct however to think of the IMbark or the matched data from Moffett BAT arms (about 15-16 mOS) presented early in Dr. K's abstract as relevant to what the BAT arm in Impact will be. The BAT arm in Impact will very likely be considerably longer for all the reasons we discussed but will not likely approach the mOS of 39 months in the post 2019 registry.

Speaking for myself, unwinding the data in the abstract has been very helpful as we wait for the interim announcement (stop for futility, stop for efficacy, continue to completion.). Special thanks to MG for helping me and (I hope the board also) understand what the message in this abstract actually represented.

[seedylemon]

BP:
Your exchanges with MG on the workings of clinical trials these past few weeks have been invaluable. I have even come to tolerate AI for a spell. Thank you all.

[biopearl123]

Seedylemon, I can assure you that I am just finding my way with this along with the rest of us. It's definitely a work in progress. My favorite saying:
"Surround yourself with those who search for the truth and run like hell from those who have found it." I think we are all still searching. "Scio me nihilism scire". I agree with you that MG has done yeoman's work.