ImetelChat

This will finally tell us whether the second generation of anti-telomerase-positive cell oncology drugs works.

If MAIA's 6-thio-dG works, it will be applicable as an adjunct therapy on the 85% of cancers that are telomerase-positive. A big deal for a $71 million market cap company, and for cancer ...

"Imatetelstat, Geron’s key drug"

Great source

Seriously, though Geron isn't working on it, there has been progress on telomerase activators recently:

https://www.cell.com/cell/abstract/S009 ... 24)00592-0

Oligo manufacturing is a matter of picking up a phone and calling an oligo supplier. Pretending that this is a problem is just ridiculous.

The most important part of perspective is watching the other companies in the same space. Read the data that MAIA presented at ASCO:
https://d1io3yog0oux5.cloudfront.net/_6 ... g_Deck.pdf

Huge increase in median OS in 3L at the 180 mg dose and some of the patients are still alive. The cohort is too small, but if this continues to hold up then 6-thio-dG really is a platform drug.
https://d1io3yog0oux5.cloudfront.net/_6dae8937b5d67d7bd3a4f1d3eca08882/maiabiotech/db/2216/20746/pdf/MAIA ...

Just in from Rockefeller paper, everything we know is wrong. We had the very basics of DNA replication wrong. Big implications for Imetelstat. I don't see any problem for 6-thio-dG, but would like to hear any ideas on it.

https://www.rockefeller.edu/news/35439-double-trouble-at-chromosome-ends ...

6-thio dG doesn't inhibit telomerase. It kills cells that have active telomerase.

What was JNJ doing with Gryaznov for two decades? Why didn't they try to nail down patents in the telomerase/telomere field?

https://www.businesswire.com/news/home/20240124751468/en/MAIA-Biotechnology-Announces-Publication-of-International-PCT-Patent-Application-Covering-Anticancer-Telomere ...

MAIA update presentation. Apparently they had 60 Phase 2 patients when they made the slides, and they expect to present efficacy data at ASCO in early June:
https://d1io3yog0oux5.cloudfront.net/_1 ... owcase.pdf

Oh c'mon Jayfish, how can you look at that crumbling Mayo mansion in its fake Japanese swamp south of town and think that the Mayo shoggoths might be out to get you? ;)

(Worked at Poeschla Lab at Mayo for nearly 3 years. Then everyone in the lab left Mayo for elsewhere... it's a nice place, but ...

Remember that the CRSP vector works and is less likely to cause cancer than BLUE's... but CRSP uses FETAL hemoglobin. Women with fetal hemoglobin don't have babies with fully developed brains.

Latest presentation from MAIA. This is bigger than PCYC... getting in at this level will let everyone recover their GERN losses and more. Happy Holidaze everyone!

https://www.channelchek.com/videos/maia ... n19-replay

"For Blood And Money" by Vardi. Covers the insanity behind the PCYC buyout and drug approval. Apparently it helps to have a deranged Scientologist running the company... one wonders when one of our genius billionaires will realize that the FDA "system" is killing them along with us peons...

ADCOMs do not "shorten timelines". They can kill the drug, but there is no mechanism to speed things up. That's not how FDA works.

(?) The FDA rejected priority review for Imetelstat... EVEN THOUGH WE HAD FAST TRACK!

This is how they kill biotechs... just delay delay delay.

18,000 FDA employees, and they can't do priority review for Fast Track drug? Absurd.

Thanks for your recent posts, kmall, you make some good points. However, you can't stick with your "Bill iS a rEpTile aLiEN" stuff unless you actually believe that I have time travel tech... I have posted the subjects of op-eds and scientific papers on YHOO BEFORE THEY WERE PUBLISHED many times over ...

Don't forget the work from the Conboy Lab (and every other parabiosis lab going back to 1855 Paris)... that young plasma is really good for you. Mostly not because of what it adds, but because it is diluting the "self-destruct" factor in old blood.

Thanks. This poster doesn't seem to back up any SF3B1 limitations... in fact, it doesn't seem useful for further genetic targeting at all, which is unfortunate. Hopefully there is better data from the Phase 3.

Thanks for the employee list, kmall.

Imetelstat is RNA, it binds to the hTR RNA, not to proteins.