ImetelChat

I can somewhat understand the attack dog mentality of the FDA rep as Imetelstat is a first in class novel drug never before approved for any indication. The FDA rep was intelligent and very data literate….. but Imetelstat treatment approaches and outcomes that vary significantly based on individual ...

Voting in progress.

Perhaps those on the FDA board are simply not as experienced as Geron is in interpreting this data and knowing what IWG criteria applies....as the hematologic improvement-erythroid (HI-E) data analysis between the IWG 2018 and IWG 2006 criteria for the Geron study have significant differences in how ...

Biopearl

However, this Imetelstat/Geron adventure plays out, I want to thank you for being a beacon of light and information during the last ... over these many - many years?

I'm glad to see PPS headed up... In typical Geron management style... the entire investment community is waiting for news ...

Thanks Ryan. Happy New year to all who follow Geron. .... earfool.

Thanks to all who manage and contribute to Imetelstat.

I was delighted to make a contribution to this worthy cause. Although opinions differ about Imetelstat on this forum... all discussions are a pleasure to read and participate in. Imetelstat is pretty much free of the idiocy and acrimonious ...

Kmall

Thanks for your informative posts. YMB is a waste of time for the most part but it does have it's moments and you were one of the reasons I checked in once in a while.

All the best..

.....earfool

Kmall

Thanks for your informative posts. YMB is a waste of time for the most part but it does have it's moments and you were one of the reasons I checked in once in a while.

All the best..

.....earfool

---Jakafi Paradox-- the Sequel
**Enhancement** of Myeloproliferative Stem Cells

(Enhancement) - the process of making something greater… normally we think of enhancement as a good thing… but significantly enhancing cancer *stem* cells that enable cancer cells to grow back with often a vexing ...

Hello biopearl123

I agree that J&J could very well be prioritizing immunotherapy. J&J also is very much into consumer perception and immunotherapy is more natural sounding….our own bodies fighting cancer with the help of J&J. Certainly, immune systems are better understood than Telomerase ...

Hi thanks for your post

The patent you found reports on TANKYRASE inhibition...from an article written by Solberg in the publication Molecular Cancer research...they state Tankyrase inhibition ultimately affects β-CATENIN and AKT signaling in colorectal cancer. Although I don't think Imetelstat has ...

A very brief cursory review of the literature shows imetelstat used, mentioned or quoted in several 2018 publications ..below are a few of them


JC Schmidt, AJ Zaug, R Kufer… - Molecular biology of the …, 2018 - Am Soc Cell Biol
… Imetelstat and the mismatched control oligonucleotide were a gift ...

Hello all. There are several studies that suggest patients remaining red blood cell transfusion-dependent have important implications in hematological disorders because it strongly-correlated with decreased survival. Conversely, any drug that is shown to help subjects become RBC-transfusion ...