Fenaux study

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biopearl123
Posts: 486
Joined: Fri Jul 20, 2018 5:13 pm

Fenaux study

Post by biopearl123 » Sat Sep 29, 2018 7:51 pm

As I look back over the Fenaux presentation, if you check Figure 3. Example of a 24-week TI responder, this patient doesn't leave the yellow zone until week 42! They he enters the grey zone and stays there until the end of data collection. Can anyone get any sense for when Janssen actually "opened the window" for their snapshot and see any way to project what might happen to responders late in the game like the patient in this study. bp
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huntingonthebluffs
Posts: 154
Joined: Wed Feb 24, 2016 12:00 am

Re: Fenaux study

Post by huntingonthebluffs » Mon Oct 01, 2018 5:36 pm

Good question and I know your understanding and opinion would be far above anything I could add and sure others here can offer more knowledgeable opinions as well. However, when I looked at the chart, the last transfusion occurred at week 11, so 8 week TI was at week 19 and 24 week TI was at week 33. The dose was lowered from 7.5 to 6.0 at week 25 so maybe after the 8 week TI they step the dose down to 6.0 and stays there well past 24 week TI at week 33 and finally steps down to the maintenance level 4.75 at 71 weeks.

I suspect the platelets and ANC levels help indicate the dose and TI durability and maybe when to take the readout but as a layman I would think the readout is around week 33 between 6-7 months.

BTW, I wasn’t able to come up with a bookmark for the Fenaux study with a chart on slide 3, I did fine the chart (page 15) in a Geron presentation at this link:

http://ir.geron.com/static-files/0c553e ... 2c8870b371

Looking forward to more thoughts on your post.
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