2018 Imetelstat used, mentioned or quoted

[earfool]

A very brief cursory review of the literature shows imetelstat used, mentioned or quoted in several 2018 publications ..below are a few of them


JC Schmidt, AJ Zaug, R Kufer… - Molecular biology of the …, 2018 - Am Soc Cell Biol
… Imetelstat and the mismatched control oligonucleotide were a gift of Janssen Research &
Development, LLC (Raritan, NJ). Ime- telstat and the mismatched control oligonucleotide were
dissolved in PBS …..

TT DeLeon, DH Ahn, JM Bogenberger… - Future …, 2018 - Future Medicine
… TERT promoter, Telomerase, 47.1–60%, Imetelstat GX301 GV1001, None NCT02293707
NCT00444782, II II, … Imetelstat is a drug that targets the RNA template of TERT and inhibits
telomerase activity in cell lines and patient derived xenografts models

S Sengupta, M Sobo, K Lee, SS Kumar, AR White… - Molecular cancer …, 2018 - AACR
… We have previously shown that over 73% of DIPG and 50% of high-grade gliomas (HGG) (10)
demonstrate telomerase activity. We recently conducted a molecular biology and phase II study
of imetelstat, a potent inhibitor of … imetelstat to allow sustained telomerase inhibition

RM Alves‐Paiva, S Kajigaya, X Feng, J Chen… - Liver …, 2018 - Wiley Online Library
… extra-telomeric regions of the genome to regulate gene expression. Clinical studies have
recently addressed the efficacy of Imetelstat, a telomerase … Telomerase Inhibitor Imetelstat in
Patients with Essential Thrombocythemia

SR Bollam, ME Berens, HD Dhruv - Current neurology and neuroscience …, 2018 - …. Imetelstat (GRN163L) is a competitive telomerase
inhibitor which originally had success against myeloproliferative neoplasms and recently
demonstrated potent telomerase inhibition in CNS tumors


U Tabori, P Castelo-Branco - US Patent 9,896,732, 2018 - Google Patents
… graphically illustrates that treatment of hypermethylated neuroblastoma cells with
imetelstat has an inhibitory effect on growth and viability, while treatment of unmethylated
neuroblastoma cells did not

G Zhang, LW Wu, M Barzily-Rokni, MR Hammond… - Clinical Cancer …, 2018 - AACR
… The lipid modified 13-mer thio- phosphoramidate oligonucleotide is a telomerase template
antagonist GRN163L (Imetelstat) as … were indeed decreased in A375 cells treated with
6-thio-dG but not BIBR 1532 or another telomerase inhibitor, GRN163L (Imetelstat)

EQ Lee - Handbook of Brain Tumor Chemotherapy, Molecular …, 2018 - Elsevier
… The antisense oligonucleotide therapy GRN163L (Imetelstat) blocks telomerase and reduces
GBM growth in preclinical models [31]

C Liu, S Hao - Precision Molecular Pathology of Myeloid Neoplasms, 2018 - Springer
… Imetelstat (GRN163L) is a 13-mer lipid-conjugated oligonucleotide that targets the RNA template
of human telomerase reverse transcriptase. It inhibits telomerase activity and cell proliferation …
Imetelstat was shown to have the potential to reverse bone marrow fibrosis

A Chakraborty, J Han, C Faltas… - Cancer and Clinical …, 2018 - ccsenet.org
… Treatment of glioblastoma cells with the telomerase inhibitor imetelstat alone, or in combination
with temozolomide and radiation, progressively shortened the length of telomeres, induces slowed
cell proliferation and leads to eventual cell death

A Shreenivas, J Mascarenhas - Expert opinion on emerging drugs, 2018 - Taylor & Francis
… Imetelstat (GRN163L, Geron) is an oligonucleotide inhibitor of telomerase activity by
competitively binding the RNA component of the enzyme

F Passamonti, M Maffioli - Blood, 2018 - Am Soc Hematology
… on April 14, 2018. by guest www.bloodjournal.org From Page 8. 8 Another similar discrepancy
has been described with imetelstat (a telomerase inhibitor) in ET. 68 This molecule obtained
100% hematological responses and 88% partial molecular responses

[biopearl]

Earfool, thank you for posting this interesting compendium of relevant articles. I apologize for not getting them on the board sooner as I am learning my way around the automatic "stops" that require review for all new posters. I will be more diligent about this (its a small box with a notification to me that I just missed but now know how to find it.) It should not be a problem in the future. Again apologies, please keep posting. After today's PR I think we can all use some reassurance. bp