ImetelChat

Informative video from Alessandro Vannucchi about imetelstat in the landscape various other approaches.

https://www.youtube.com/watch?v=x-VqRLEZylQ
About imetelstat he says:
'One of these new drugs that are the most appealing based on the results of the Phase2 trials, is off course imetelstat.'
(starts on 5:55)

He is not enthusiastic about combinations with Jakafi:
'There are toxicities associated with the use of these combinations, that are still raising doubts about the feasibility and clinical relevance of making this associations'
'The current idea is that these associations are not worth while right now for further clinical study for the clinical trials'
(starts on 4:59)

About to watch this, but both drugs can cause thrombocytopenia, so I doubt any overlapping combo tx would be contemplated. Maybe alternating, as in getting these dz under control, then switching to the jak inhibitor for some symptomatice relief seems logical, but probably too simplematic for today’s medical world.