Overview heme diseases in oncology space
Posted: Fri Jul 15, 2016 5:57 pm
Because imetelstat is being mentioned as being specifically promising in heme-onco diseases, it may be interesting to make an inventory of the potential indication. Clayton1021 has posted this impressive list on SA:
Myeloproliferative neoplasms
"Myeloproliferative neoplasms are a type of blood cancer that includes:
Imyelofibrosis
polycythemia vera
essential thrombocythemia."
Myelodysplastic syndromes (MDS)
"The system used today is the World Health Organization (WHO) classification… The WHO system recognizes 7 types of MDS:"
1. Refractory cytopenia with unilineage dysplasia (RCUD)
2. Refractory anemia with ringed sideroblasts (RARS)
3. Refractory cytopenia with multilineage dysplasia (RCMD)
4. Refractory anemia with excess blasts-1 (RAEB-1)
5. Refractory anemia with excess blasts-2 (RAEB-2)
6. Myelodysplastic syndrome, unclassified (MDS-U)
7. Myelodysplastic syndrome associated with isolated del(5q)
Leukemia
Acute myeloid leukemia (AML); Has too many subtypes to list
Chronic myeloid leukemia (CML)
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL)
Hairy cell leukemia
Chronic myelomonocytic leukemia (CMML)
Juvenile myelomonocytic leukemia (JMML)
Lymphoma
- Non-Hodgkin lymphoma
"There are more than 30 distinct types of non-Hodgkin lymphoma, which can be divided into aggressive (fast-growing or high grade) or indolent (slow-growing or low grade) types."
"NHL is further divided according to the cell type involved. There are two main types of lymphocytes: B-lymphocytes (or B cells) and T-lymphocytes (or T cells). Most types of non-Hodgkin lymphomas develop from B cells."
1. "Some forms of B-cell NHL include: diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma and mantle cell lymphoma."
2. "Some forms of T-cell NHL include: mycosis fungoides, anaplastic large cell lymphoma, peripheral T-cell lymphoma and precursor T-lymphoblastic lymphoma."
- Hodgkin lymphoma
"Hodgkin lymphoma is marked by the presence of an abnormal lymphocyte called the Reed-Sternberg cell (or B lymphocyte)."
1. Classical Hodgkin lymphoma (majority of cases)
2. Nodular lymphocyte-predominant Hodgkin lymphoma
Multiple Myeloma
1. Monoclonal Gammopathy of Undetermined Significance (MGUS), (pre-cancerous)
2. Asymptomatic (Smoldering/Indolent) Myeloma
3. Symptomatic (Active) Myeloma
Solitary plasmacytoma of the bone is one tumour made up of myeloma cells found in one bone
4. Solitary plasmacytoma of the bone
5. Multiple solitary plasmacytomas
6. Extramedullary plasmacytomas
7. light chain myeloma
8. Non-secretory myeloma
- Rare types of Multiple Myeloma
1. immunoglobulin D (IgD) myeloma
2. immunoglobulin E (IgE) myeloma
Other plasma cell cancers
1. Plasma cell leukemia (PCL)
2. Osteosclerotic myeloma (POEMS syndrome)
3. Waldenstrom macroglobulinemia
Some links:
http://www.cancercenter.com/terms/hemat ... alignancy/
https://www.uihealthcare.org/2column.aspx?id=228179
http://www.cancer.ca/en/cancer-informat ... ?region=on
https://www.lls.org/disease-information
http://m.cancer.org/cancer/myelodysplas ... -d-s-types
Myeloproliferative neoplasms
"Myeloproliferative neoplasms are a type of blood cancer that includes:
Imyelofibrosis
polycythemia vera
essential thrombocythemia."
Myelodysplastic syndromes (MDS)
"The system used today is the World Health Organization (WHO) classification… The WHO system recognizes 7 types of MDS:"
1. Refractory cytopenia with unilineage dysplasia (RCUD)
2. Refractory anemia with ringed sideroblasts (RARS)
3. Refractory cytopenia with multilineage dysplasia (RCMD)
4. Refractory anemia with excess blasts-1 (RAEB-1)
5. Refractory anemia with excess blasts-2 (RAEB-2)
6. Myelodysplastic syndrome, unclassified (MDS-U)
7. Myelodysplastic syndrome associated with isolated del(5q)
Leukemia
Acute myeloid leukemia (AML); Has too many subtypes to list
Chronic myeloid leukemia (CML)
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL)
Hairy cell leukemia
Chronic myelomonocytic leukemia (CMML)
Juvenile myelomonocytic leukemia (JMML)
Lymphoma
- Non-Hodgkin lymphoma
"There are more than 30 distinct types of non-Hodgkin lymphoma, which can be divided into aggressive (fast-growing or high grade) or indolent (slow-growing or low grade) types."
"NHL is further divided according to the cell type involved. There are two main types of lymphocytes: B-lymphocytes (or B cells) and T-lymphocytes (or T cells). Most types of non-Hodgkin lymphomas develop from B cells."
1. "Some forms of B-cell NHL include: diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma and mantle cell lymphoma."
2. "Some forms of T-cell NHL include: mycosis fungoides, anaplastic large cell lymphoma, peripheral T-cell lymphoma and precursor T-lymphoblastic lymphoma."
- Hodgkin lymphoma
"Hodgkin lymphoma is marked by the presence of an abnormal lymphocyte called the Reed-Sternberg cell (or B lymphocyte)."
1. Classical Hodgkin lymphoma (majority of cases)
2. Nodular lymphocyte-predominant Hodgkin lymphoma
Multiple Myeloma
1. Monoclonal Gammopathy of Undetermined Significance (MGUS), (pre-cancerous)
2. Asymptomatic (Smoldering/Indolent) Myeloma
3. Symptomatic (Active) Myeloma
Solitary plasmacytoma of the bone is one tumour made up of myeloma cells found in one bone
4. Solitary plasmacytoma of the bone
5. Multiple solitary plasmacytomas
6. Extramedullary plasmacytomas
7. light chain myeloma
8. Non-secretory myeloma
- Rare types of Multiple Myeloma
1. immunoglobulin D (IgD) myeloma
2. immunoglobulin E (IgE) myeloma
Other plasma cell cancers
1. Plasma cell leukemia (PCL)
2. Osteosclerotic myeloma (POEMS syndrome)
3. Waldenstrom macroglobulinemia
Some links:
http://www.cancercenter.com/terms/hemat ... alignancy/
https://www.uihealthcare.org/2column.aspx?id=228179
http://www.cancer.ca/en/cancer-informat ... ?region=on
https://www.lls.org/disease-information
http://m.cancer.org/cancer/myelodysplas ... -d-s-types