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For YMB readers:

Posted: Sat Dec 03, 2022 8:38 pm
by biopearl123

Re: For YMB readers:

Posted: Sat Dec 03, 2022 9:47 pm
by cheng_ho
Thanks. This poster doesn't seem to back up any SF3B1 limitations... in fact, it doesn't seem useful for further genetic targeting at all, which is unfortunate. Hopefully there is better data from the Phase 3.

Re: For YMB readers:

Posted: Sun Dec 04, 2022 1:25 am
by Ryan
I’d say the Conclusion is the best part. It’s pretty straight forward.

Per the yahoo ad naseau, I would point out these words:
“across different molecularly defined subgroups”

These words are preceded by “demonstrated clinical efficacy”.

Imetelstat demonstrated clinical efficacy across different molecularly defined subgroups of heavily transfused LR-MDS ESA-R/R patients, including those with poor prognosis, who have limited treatment options.

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9. Platzbecker U et al, ASH 2020 Oral presentation, Abstract #658