Another potential combination with possible far reaching consequences

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biopearl123
Posts: 1665
Joined: Fri Jul 20, 2018 5:13 pm

Another potential combination with possible far reaching consequences

Post by biopearl123 » Tue Sep 20, 2022 9:06 pm

It was said many years ago that the reason Imetelstat failed in solid tumor studies was because (in addition to requiring multiple cell divisions), the effect on telomere shortening “escaped” with the help of alternative mechanisms for telomere maintenance (ALT). Here’s a look at a sequential telomerase inhibitor followed by an agent (already on the market) that has ALT effects in preclinical work in lymphoma:

https://mdpi-res.com/d_attachment/biome ... 1663550578

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