Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

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mistergern
Posts: 18
Joined: Sat Mar 19, 2016 3:48 pm

Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

Post by mistergern » Tue Aug 09, 2022 2:05 am

Imetelstat and HIF inhibitors evolving use in MDS
Valeria Santini University of Florence, Florence, Italy

https://www.vjhemonc.com/event/iwmds-2022/

At Minute 8:08 Dr Santini states that she's had patients on Imetelstat for years - very positive video.

biopearl123
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Joined: Fri Jul 20, 2018 5:13 pm

Re: Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

Post by biopearl123 » Tue Aug 09, 2022 2:35 am

mistergern, thank you for posting this. Dr. Santini clearly has a lot of experience with Imetelstat. One interesting small note is that we know the last patient was enrolled on Oct 1st 2021. The study technically ends one year after the last patient was enrolled. This means to me the blinding process ends then, I could be wrong about that. Much of the data has already been collected. Geron has guided results mid January but I do wonder if a late breaking submission for the Dec ASH meeting(finally) could be possible if data analysis allows. I don’t know if that would be possible but could certainly make a splash if so. bp

kmall
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Re: Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

Post by kmall » Tue Aug 09, 2022 4:21 am

Any one take note of the sponsors........??

Platinum: Gilead & Novartis

Gold: Bristol Meyers Squibb

Silver: Syros

Bronze: Geron & Kayropharm

Looks like Geron is making a name for itself in the Hematological space already...... pre-approval and pre-commercialization.

Pretty exciting stuff I'd say. -Kmall

Hoosier Investor
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Re: Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

Post by Hoosier Investor » Tue Aug 09, 2022 5:13 am

What was the part about "not many patients enrolled yet" in the QT part (extension) of the study?

Do we know if that part has been fully enrolled yet?

biopearl123
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Re: Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

Post by biopearl123 » Tue Aug 09, 2022 2:56 pm

HI not sure that timeline matters too much. TLR could still be released as planned while QT study still being completed. Pts probably have to get ECGS every hour around the clock for some period so it’s cumbersome. The QT interval is a direct measurement off the cardio gram and should be straightforward to obtain.

biopearl123
Posts: 918
Joined: Fri Jul 20, 2018 5:13 pm

Re: Imetelstat and HIF inhibitors evolving use in MDS Valeria Santini

Post by biopearl123 » Fri Aug 12, 2022 3:56 am

Kmall, good points. Considering there are about 18,000 members of the Society, a substantial number including those from around the world will be attending the meetings. Sponsorship not only gets the name and information out but I imagine a prominent “booth” with information and personnel present to talk directly to care givers will be in evidence. They are turning up the heat.

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