I am trying to digest the concept of a JNJ “miracle cure” (if it proves out), without Imetelstat in the mix. However promising this JNJ medicine is, it would likely be better with Imetelstat as an addition.The topic and discussion of this thread centered on JNJ-74856665 used in combination with Azacitidine or Venetoclax. Similar to the upcoming TELOMERE P1/2 Clinical Trial using Imetelstat in combination with Azacitidine or Venetoclax. Once approved, Imetelstat as a single agent off label could possibly be a more efficient and effective means of treatment. However, for certain cancers and in the case of the patient in this discussion with AML and a two month survival expectancy, certain drug combinations, or in this example, the combination of JNJ-74856665 with Azacitidine or Venetoclax, has so far proven successful as a "miracle cure" - cited in the article. -Kmall
AbbVie is the combination key here (Azacitidine or Venetoclax) in both JNJ-74856665 and the TELOMERE/AML trial. The common interests of Geron, AbbVie and JNJ are obvious as we move forward with new combination treatments for an assortment of blood cancers.
There are many irons in the fire, with Imetelstat becoming an important part of the ongoing Cancer Moonshot endeavor. Telomerase inhibitors, such as Imetelstat, will be part of the 'cancer-solution'. It may be too early to talk about cures, but we can talk about improved treatments, longer survival time, disease modification and killing cancer-stem-cells.
Azacitidine is designed to slow the production of leukemia cells and help the bone marrow produce more healthy and normal functioning cells. Venetoclax is designed to kill leukemia cells by binding to and inhibiting a protein in cancerous cells that prevents the cell from dying known as “BCL-2”
Common brand names: Venclexta
This medication is used to treat certain types of cancer (chronic lymphocytic leukemia-CLL, small lymphocytic lymphoma-SLL, acute myeloid leukemia-AML).
May Treat: Acute myeloid leukemia · Chronic lymphocytic leukemia · Small lymphocytic lymphoma
Brand Names: Venclexta · Venclexta Starting Pack
Drug Class: Antineoplastic - B-cell lymphoma-2 (BCL-2) inhibitors
Availability: Prescription Required
Pregnancy: Consult your doctor. This medication may be harmful to an unborn child.
Lactation: This drug should not be given to breastfeeding mothers
What are the uses of venetoclax?
Venetoclax is also used in combination with other medicines to treat acute myeloid leukemia in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.