AbbVie snaps up a bispecific for multiple myeloma in TeneoOne buyout

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Austin417
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Joined: Wed Oct 31, 2018 9:57 pm

AbbVie snaps up a bispecific for multiple myeloma in TeneoOne buyout

Post by Austin417 » Thu Jun 24, 2021 6:12 pm

Interesting.

"Fol­low­ing a pos­i­tive in­ter­im Phase I read­out, Ab­b­Vie is ex­er­cis­ing an op­tion to ac­quire TeneoOne and its BC­MA can­di­date TNB-383B for re­lapsed or re­frac­to­ry mul­ti­ple myelo­ma.

Ab­b­Vie inked a deal with TeneoOne back in 2019 to de­vel­op and com­mer­cial­ize TNB-383B, a bis­pe­cif­ic an­ti­body that tar­gets BC­MA and CD3. The treat­ment is de­signed to di­rect the body’s im­mune sys­tem against BC­MA-ex­press­ing tu­mor cells. And ac­cord­ing to in­ter­im re­sults, the can­di­date showed a 79% ob­jec­tive re­sponse rate in a Phase I study. Six­ty-three per­cent of pa­tients saw a “very good par­tial re­sponse” or bet­ter, and 29% saw a com­plete re­sponse at dos­es greater than or equal to 40 mg at a me­di­an fol­low-up of 6.1 months.

"While oth­er BC­MA and CD3 bis­pe­cif­ic ther­a­pies re­quire week­ly ad­min­is­tra­tion, the rec­om­mend­ed Phase 2 dose of TNB-383B will in­ves­ti­gate in­fre­quent dos­ing of every 3 weeks for in­tra­venous ad­min­is­tra­tion, which is an im­por­tant treat­ment fac­tor for peo­ple liv­ing with mul­ti­ple myelo­ma,” Ab­b­Vie’s vice chair­man and pres­i­dent Michael Sev­eri­no said in a state­ment.

At the in­ter­im analy­sis, 103 par­tic­i­pants had been dosed with TNB-383B. The tri­al is be­ing con­duct­ed in pa­tients who have had at least three pri­or lines of treat­ment.

The re­sults al­lowed the Ab­b­Vie team to “make this de­ci­sion with con­fi­dence," Sev­eri­no said. — Nicole De­Feud­is"


https://endpts.com/abbvie-snaps-up-a-bi ... k-program/

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