New Tefferi paper text (4)

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cheng_ho
Posts: 202
Joined: Sun Apr 03, 2016 11:27 pm

New Tefferi paper text (4)

Post by cheng_ho » Mon Apr 19, 2021 5:10 pm

lenalidomide have also been reported in MDS-RS.21 By contrast, as was underlined in the current edition of AJH by Montalban-Bravo et al,2 as well as noted in previous publications,15 therapeutic success with hypomethylating agents in MDS/MPN-RS-T has been less than stellar and not much better in MDS-RS.21 Regardless, current data argues for the value of ESAs as front-line treatment of choice for anemia associated with MDS/MPN-RS-T or MDS-RS and identify lenalidomide as a reasonable second-line treatment of choice, before resorting to luspatercept.22 Whether or not newer drugs, in-class or otherwise, that target specific regulators of erythropoiesis, including those that modulate hepcidin expression, would perform better remains to be seen

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