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Thrombocytopenias

Posted: Thu Oct 22, 2020 8:00 am
by Gwikley
Would someone tolerate an old fool who cannot seem to locate the answer to my search question: " Has Geron resolved, or lessened the threat of. the development of thrombocytopenias with this drug? "
Thanks in advance.

Re: Thrombocytopenias

Posted: Thu Oct 22, 2020 6:49 pm
by biopearl123
Gwikley, this article directly addresses your question. Imetelstat works directly on normal stem cells also and affects megakaryocyte Precursors. It is treated with dose reductions. Fortunately the effects on the malignant stem cell are disproportionate to normal stem Cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555816/

Re: Thrombocytopenias

Posted: Thu Oct 22, 2020 7:43 pm
by Gwikley
What a resource you are! lol.....read from top to bottom..........thank you!!