Thrombocytopenias

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Gwikley
Posts: 100
Joined: Thu Aug 30, 2018 9:05 pm

Thrombocytopenias

Post by Gwikley » Thu Oct 22, 2020 8:00 am

Would someone tolerate an old fool who cannot seem to locate the answer to my search question: " Has Geron resolved, or lessened the threat of. the development of thrombocytopenias with this drug? "
Thanks in advance.

biopearl123
Posts: 1665
Joined: Fri Jul 20, 2018 5:13 pm

Re: Thrombocytopenias

Post by biopearl123 » Thu Oct 22, 2020 6:49 pm

Gwikley, this article directly addresses your question. Imetelstat works directly on normal stem cells also and affects megakaryocyte Precursors. It is treated with dose reductions. Fortunately the effects on the malignant stem cell are disproportionate to normal stem Cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555816/

Gwikley
Posts: 100
Joined: Thu Aug 30, 2018 9:05 pm

Re: Thrombocytopenias

Post by Gwikley » Thu Oct 22, 2020 7:43 pm

What a resource you are! lol.....read from top to bottom..........thank you!!

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