Search found 202 matches

by cheng_ho
Wed Apr 01, 2020 9:58 pm
Forum: ImetelChat
Topic: Telomerase
Replies: 3
Views: 2787

Re: Telomerase

I answered gwik on ST... the quick answer is yes, there are many other telomerase-inhibitor drugs already in use. Azacitidine is currently in many combo trials, including the ARGX trial that JNJ funded heavily right after dropping Geron. Also check out Constellation... just do searches on "MDS" and ...
by cheng_ho
Thu Mar 26, 2020 3:59 pm
Forum: ImetelChat
Topic: Successful ABBV telomerase-inhibitor combo study in AML
Replies: 0
Views: 1798

Successful ABBV telomerase-inhibitor combo study in AML

So ABBV got good results in VERY sick AML patients,using azacitidine as their telomerase inhibitor along with Venclexta. Other companies are using the ancient 1990s telomerase inhibitors in trials as well, ARGX, Constellation, and many others. Why are these companies avoiding collaboration with Gero...
by cheng_ho
Mon Mar 23, 2020 5:10 pm
Forum: ImetelChat
Topic: Since everyone is on lockdown....
Replies: 1
Views: 2884

Re: Since everyone is on lockdown....

Obviously the TERT promoter has to mutate in order to upregulate telomerase in cancer cells. What "Geron R&D" are you talking about? Did they build a lab somewhere? AFAIK they have an office in NJ that does CTPM for the trials, and an office in Menlo Park that pays the largest average salaries in CA...
by cheng_ho
Fri Mar 13, 2020 10:32 pm
Forum: ImetelChat
Topic: Good Bye
Replies: 4
Views: 3108

Re: Good Bye

Good luck, kara. Check out those papers on NAD+ boosting and telomerase activation... there's still a chance for you to hang on until the real Age Of Biotech starts.
by cheng_ho
Mon Mar 02, 2020 8:27 pm
Forum: ImetelChat
Topic: Perspective on the MF field
Replies: 7
Views: 5280

Re: Perspective on the MF field

Scarlett never addressed why JNJ was looking for a pricing manager for imetelstat for AML in addition to MDS and MF - that came out of nowhere - I would like to go to the shareholders meeting to ask him that question - was it a surprise to him or was he aware they were working on something? I am su...
by cheng_ho
Mon Mar 02, 2020 4:41 pm
Forum: ImetelChat
Topic: FTSV acquisition by GILD
Replies: 4
Views: 4600

FTSV acquisition by GILD

Clearly, big pharma is interested in the MDS/AML market, they see it as large and effective therapy as attainable.

JNJ is invested in ARGX and Constellation, now GILD has bought out FSTV.

Any thoughts as to why no pharma has shown interest in Geron?
by cheng_ho
Mon Mar 02, 2020 4:38 pm
Forum: ImetelChat
Topic: Perspective on the MF field
Replies: 7
Views: 5280

Re: Perspective on the MF field

i think they bailed due to the italian paper on MOS - when it came out there was no chance to refute it or prove it and thus they didn't feel comfortable in committing up to a billion dollars to continue - that killed the deal - the FDA must think there is something here to grant fast track after l...
by cheng_ho
Tue Feb 25, 2020 4:49 pm
Forum: ImetelChat
Topic: Perspective on the MF field
Replies: 7
Views: 5280

Perspective on the MF field

MF is a lot smaller market... but there are still many current trials, some of them even combo trials.

https://clinicaltrials.gov/ct2/results? ... ity=&dist=
by cheng_ho
Mon Feb 24, 2020 10:45 pm
Forum: ImetelChat
Topic: Review paper on low-risk MDS, brief mention of imetelstat
Replies: 0
Views: 2679

Review paper on low-risk MDS, brief mention of imetelstat

A really severe condemnation of the whole plarma/patent/FDA system... no new drug for 13 years:

https://link.springer.com/article/10.10 ... 20-03963-1
by cheng_ho
Wed Feb 19, 2020 6:39 pm
Forum: ImetelChat
Topic: new Geron patent on 6-thio-dG and other Guanine variants
Replies: 0
Views: 2603

new Geron patent on 6-thio-dG and other Guanine variants

Geron received a patent on Guanine analogs as telomerase length affectors (e.g., 6-thio-dG). More confirmation that Dr. Shay is right and that 6-thio-dG is the future... does anyone here know how this affects the MAIA IP?


https://patents.justia.com/assignee/geron-corporation
by cheng_ho
Mon Feb 10, 2020 4:01 pm
Forum: ImetelChat
Topic: Hat tip to hay flick YMB
Replies: 4
Views: 3304

Re: Hat tip to hay flick YMB

No, you were right, biopearl. Geron isn't doing genetic screening in the trials... and so far they've recruited only half the patients they need for the MDS trial, even just taking whatever victims Paraxel can find.

This is just a hope for the future. Maybe in a Phase 3 design for MF?
by cheng_ho
Sun Feb 09, 2020 2:47 pm
Forum: ImetelChat
Topic: Targeting imet on genetic subtypes: hope for effectiveness?
Replies: 0
Views: 2870

Targeting imet on genetic subtypes: hope for effectiveness?

Just as Gleevec got its reputation because it is only used on genetic subtypes where it has a better chance, Imetelstat might be developed into an effective therapy if susceptible subtypes are found. (Caffeine is actually VERY effective on cancers with a certain DNA-repair defect...) Hayflick on the...
by cheng_ho
Sun Feb 09, 2020 2:38 pm
Forum: ImetelChat
Topic: Avalanch of Classaction Lawsuits
Replies: 1
Views: 2535

Re: Avalanch of Classaction Lawsuits

Scarlett has settled past lawsuits without a fight. That's what attracts the lawyers... the last suit extracted more than $6 million, and all the firm had to do was file it. There is no Giant Short Conspiracy That Only Posts On YHOO Message Boards... no one has to pay lawyers or sharks to attack eas...
by cheng_ho
Tue Feb 04, 2020 8:15 pm
Forum: ImetelChat
Topic: Imet Angels - A grassroots movement
Replies: 4
Views: 4722

Re: Imet Angels - A grassroots movement

Shears is obviously right... Rizo had already left for CELG, she knew that the imetelstat project was going to be dropped.

Might as well ask why the guy that GERN hired from ATNM came... they're just refugees.

Notice that JNJ kept Gryzanov... he's still valuable.
by cheng_ho
Thu Jan 23, 2020 4:50 pm
Forum: ImetelChat
Topic: New Fool post
Replies: 0
Views: 3274

New Fool post

Still nothing from the real media since 2014, though.

https://www.fool.com/investing/2020/01/ ... ortfo.aspx
by cheng_ho
Fri Dec 27, 2019 4:01 pm
Forum: ImetelChat
Topic: 14 months since Gernobyl
Replies: 3
Views: 3374

Re: 14 months since Gernobyl

Janssen was clearly concerned with MDS from the beginning: https://ir.geron.com/investors/press-releases/press-release-details/2014/Geron-Announces-Global-Strategic-Collaboration-with-Janssen--to-Develop-and-Commercialize-Imetelstat/default.aspx You can't un-GERNobyl a reactor, you have to build a b...
by cheng_ho
Fri Dec 27, 2019 3:24 pm
Forum: ImetelChat
Topic: AGIO <--> GERN ....CoRelation?
Replies: 2
Views: 2641

Re: AGIO <--> GERN ....CoRelation?

The issue isn't number of patients, it's statistical power. If you get a high percentage of CRs in your 25 patients, that's a lot better than unclear results on a larger number.

That's how effective drugs get conditional approval straight out of Phase 1 and 2.
by cheng_ho
Thu Nov 21, 2019 4:08 pm
Forum: ImetelChat
Topic: The "other two" abstracts
Replies: 1
Views: 2649

Re: The "other two" abstracts

Any lab can make imetelstat with their in-house oligo synthesizer, and then do the chemical step to add the lipid tail. Geron can't stop people from researching imetelstat.