Search found 202 matches

by cheng_ho
Fri Feb 22, 2019 10:03 pm
Forum: ImetelChat
Topic: The JNJ-ARGX deal in MDS/AML
Replies: 1
Views: 1978

The JNJ-ARGX deal in MDS/AML

is there anyone who has looked at the ARGX MDS trial that doesn't think that this is why JNJ dropped imet? https://www.argenx.com/en-GB/news-internal/argenx-provides-detailed-data-from-phase-2-clinical-trial-of-efgartigimod-in-immune-thrombocytopenia-and-phase-12-clinical-trial-of-cusatuzumab-in-acu...
by cheng_ho
Mon Feb 18, 2019 9:10 pm
Forum: ImetelChat
Topic: Far from a straight line but still on course
Replies: 8
Views: 5067

Re: Far from a straight line but still on course

>"Obviously, there has been a major loss of trust in JNJ/Janssen, Geron, the FDA, the SEC, etc." Exactly. >"our primary means of voicing constructive thoughts are via emails / phone calls to Geron IR and/or written correspondence to the BoD and possibly a comment or question at the annual shareholde...
by cheng_ho
Wed Jan 09, 2019 6:47 pm
Forum: ImetelChat
Topic: So, WHICH CRO is deciding GERN's future?
Replies: 0
Views: 2297

So, WHICH CRO is deciding GERN's future?

Does anyone have any idea when we will know: Which CRO is actually going to attempt the task of recruiting for the MDS trial? (To ask patients to not take any other treatment, to use a drug dropped by big pharma, and to take the 1/3, worse than Russian Roulette, chance of dying on placebo? Seriously...
by cheng_ho
Tue Dec 04, 2018 3:57 pm
Forum: ImetelChat
Topic: Here are the slides from Dr. Mascarenhas presentation on MF
Replies: 2
Views: 2824

Re: Here are the slides from Dr. Mascarenhas presentation on MF

Good results. And Scarlett's reaction is to announce that there will be no action on MF until the end of Q3 2019!

So as always, we're more bullish than the CEO... which makes no sense at all. Things can't go better for a company than the company's own plans, only worse.
by cheng_ho
Mon Nov 26, 2018 7:27 pm
Forum: ImetelChat
Topic: compassionate use program?
Replies: 9
Views: 6651

Re: compassionate use program?

bp, JNJ did in fact say that the compassionate-use listing was a mistake. And they DID take it off the list BEFORE the discontinuation decision... to our eternal disgrace (and that of our ancestors and descendants), we all ignored that blatantly obvious sign.
by cheng_ho
Mon Nov 26, 2018 7:24 pm
Forum: ImetelChat
Topic: Phase III?
Replies: 5
Views: 4744

Re: Phase III?

Ryan, I'm sorry for your pain... mine at least ended at $2.30 ;) Geron is not "working on the MDS study". They are hiring people to supervise a clinical-trial subcontracting company sometime after the middle of 2019. Yes, the preclinical from 2016 is fascinating. So are the results of preclinicals i...
by cheng_ho
Thu Nov 22, 2018 4:00 pm
Forum: ImetelChat
Topic: Phase III?
Replies: 5
Views: 4744

Re: Phase III?

Janssen hasn't transferred the trials to GERN yet because GERN doesn't exist. They have to hire people even to supervise the new trial subcontractor. The process is going to take almost a year according to Scarlett's lackadaisical timeline. Scarlett says there won't be a Phase 3 trial until after mi...
by cheng_ho
Wed Oct 31, 2018 2:58 pm
Forum: ImetelChat
Topic: clinical update (edited for correction on address)
Replies: 1
Views: 2649

Re: clinical update (edited for correction on address)

This has been discussed on SA and YMB. Someone emailed CG Capital and they said that Janssen is still mentioned "because they still have responsibility for the trial".

So apparently Geron is going to leave the fake connection to Janssen up until Janssen sues them to take it off.
by cheng_ho
Thu Oct 04, 2018 9:22 pm
Forum: ImetelChat
Topic: Abstracts
Replies: 4
Views: 3735

Re: Abstracts

the up-front cost to JNJ for ARWR is trivial. They didn't drop imet because they didn't have the cash, they dropped it because they didn't see it working well enough.
by cheng_ho
Thu Sep 27, 2018 5:39 pm
Forum: ImetelChat
Topic: Lessons learned
Replies: 1
Views: 2230

Lessons learned

I've always complained that the "drug-development system" is no such thing. And this is a great example.... TI drugs work, but between the patent system and the monotherapy FDA trial system, they may never get into use inside the US. Those who attacked me as a "basher" for years,...
by cheng_ho
Mon Sep 10, 2018 8:45 pm
Forum: ImetelChat
Topic: Geron can continue to provide a key part of the equation
Replies: 18
Views: 19103

Re: Geron can continue to provide a key part of the equation

Geron has been out of the picture since Scarlett closed the labs all those years ago. Sergei Gryzanov was "Geron"... Scarlett is an absentee, over-retirement-age, patent troll. The sooner JNJ buys GERN patents, the sooner the quest for other TI drugs can start... at least two classes of wh...
by cheng_ho
Mon Sep 10, 2018 8:42 pm
Forum: ImetelChat
Topic: Why I have left the SA Board
Replies: 1
Views: 2539

Re: Why I have left the SA Board

Piketty has been debunked by many serious researchers. He's just clickbait. If you want to worry about something (something that creates inequality), worry about those who get to print themselves money. It's the simple problem that has plagued all modern economies. Here's one of the dozens of Pikett...
by cheng_ho
Wed Aug 15, 2018 9:49 pm
Forum: ImetelChat
Topic: EMA discussion
Replies: 4
Views: 5542

Re: EMA discussion

Sand, "Anne" has been notifying us of imminent EMA approval for years now ;)

...and maybe someday she'll be right. But right now we don't even know if Janssen has applied for anything.
by cheng_ho
Wed Aug 15, 2018 9:46 pm
Forum: ImetelChat
Topic: Look for the Continuation Decision next week
Replies: 3
Views: 5208

Re: Look for the Continuation Decision next week

I looked and I looked but I couldn't find the CD ;)

...is JNJ actually going to sit on this until Sept 28th?
by cheng_ho
Wed Aug 15, 2018 9:44 pm
Forum: ImetelChat
Topic: New Patent / IMET 2.0 ?
Replies: 3
Views: 4073

Re: New Patent / IMET 2.0 ?

This "new" patent was filed as a provisional by Sergei back in 2011.

You can read several papers on these modified G TIs on the Shay web site.

There is also this possibility for Imet 2.0:

https://www.ncbi.nlm.nih.gov/pubmed/26479411

...and everyone has known about these possibilities for years... except, apparently, JNJ ;)
by cheng_ho
Mon Jul 30, 2018 6:16 pm
Forum: ImetelChat
Topic: An excellent article by Hoosier Investor on SA
Replies: 7
Views: 11997

Re: An excellent article by Hoosier Investor on SA

Hoosier has presented a very good summary of the possible upside scenarios.

Of course that means he will now be struck down by an unexplainably improbable concentration of cosmic rays. Farewell, Hoosier.
by cheng_ho
Wed Jun 13, 2018 4:50 pm
Forum: ImetelChat
Topic: Goodbye
Replies: 9
Views: 13299

Re: Goodbye

RIP Fish. Too bad he never had access to imetelstat.
by cheng_ho
Fri May 25, 2018 5:29 pm
Forum: ImetelChat
Topic: Imetelstat....real life story
Replies: 3
Views: 8859

Re: Imetelstat....real life story

Uh, didn't we hear that "John" DIED a long time ago?
by cheng_ho
Mon Oct 23, 2017 10:09 pm
Forum: ImetelChat
Topic: Geron patent published: Method for identification of sensitivity of a patient to telomerase inhibition therapy
Replies: 2
Views: 2399

Re: Geron patent published: Method for identification of sensitivity of a patient to telomerase inhibition therapy

I don't think this patent will apply to any therapeutic use of imet. Real-world therapies will always be combinations, so the issue of resistance to imet will be avoided. This is a good thing for imet's possible clinical use, of course.... the patent aims to limit the applicable patient population b...
by cheng_ho
Sun Feb 26, 2017 12:33 am
Forum: ImetelChat
Topic: Dormant study revived?
Replies: 6
Views: 5121

Re: Dormant study revived?

Thanks for doing the legwork there Fish.