Search found 1665 matches

by biopearl123
Tue Feb 27, 2024 9:00 pm
Forum: ImetelChat
Topic: ODAC
Replies: 0
Views: 906

ODAC

https://www.regulations.gov/document/FDA-2024-N-0016-0001 Comments submitted before Feb 29th will be presented to the committee. Comments after that date will be taken into consideration by the FDA. If you or anyone you know want their comments considered, there is a time deadline. So far only a few...
by biopearl123
Tue Feb 27, 2024 6:06 am
Forum: ImetelChat
Topic: A blessing from the hepatologists Major hat tip to Wildrides YMB
Replies: 5
Views: 1523

Re: A blessing from the hepatologists Major hat tip to Wildrides YMB

Ryan, are you surprised? I think this is the tip of the iceberg.
by biopearl123
Mon Feb 26, 2024 5:27 am
Forum: ImetelChat
Topic: The cost to develop a new drug
Replies: 4
Views: 1082

The cost to develop a new drug

Yes we have seen a lot of dilution but how much would Janssen have spent to do the same for Imetelstat?

https://www.genengnews.com/gen-edge/the ... 3-billion/
by biopearl123
Thu Feb 22, 2024 4:24 am
Forum: ImetelChat
Topic: Blood
Replies: 3
Views: 930

Blood

I have reviewed the recent discussion. We have much to learn from other species and as Jerry Garcia would say, “the wonders of nature”. Kmall’s posts remind us of the amazing beauty around us and how the species intertwine and the respect we should have for our fragile ecosystem. Who would know that...
by biopearl123
Wed Feb 21, 2024 9:32 pm
Forum: ImetelChat
Topic: THANK YOU IMETELCHAT BOARD !!!!!
Replies: 19
Views: 2182

Re: THANK YOU IMETELCHAT BOARD !!!!!

I am traveling and will give this thread the scrutiny it deserves when I can
by biopearl123
Wed Feb 21, 2024 1:49 am
Forum: ImetelChat
Topic: A wonderful summation of the state of things
Replies: 4
Views: 890

A wonderful summation of the state of things

This is the opening paragraph of a paper by Chandhok and Sekeres in "Leukemia" Feb 15th which I can't copy here sums up the sorry state of affairs in the current treatment of LR/MDS and confirms the absence of data to support improved survival (with current treatment) and the dreadful dependence of ...
by biopearl123
Tue Feb 20, 2024 5:33 pm
Forum: ImetelChat
Topic: Everything is relative
Replies: 3
Views: 574

Re: Everything is relative

Kmall, I stand happily corrected on both points
by biopearl123
Tue Feb 20, 2024 4:09 pm
Forum: ImetelChat
Topic: Everything is relative
Replies: 3
Views: 574

Everything is relative

Some as asked for a reckoning of side effects from Imetelstat. Fair enough. I think however having some framework that allows evaluation of alternatives help with perspective. Let’s start with the side effects of blood transfusions: 1. Volume overload (many patients with MPD have concurrent vascular...
by biopearl123
Mon Feb 19, 2024 10:23 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 31
Views: 6813

Re: FDA v. Geron

The editorial written by Dr. Patniak is summarized in my Dec 5th post. You do have access if you wish, there is a modest fee to Lancet for time limited access.
by biopearl123
Mon Feb 19, 2024 4:56 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 31
Views: 6813

Re: FDA v. Geron

LWS, like many things in life, this is not binary. It might be valuable to go back and review the Mayo editorial in Lancet which tries to balance a ringing endorsement with an an examination of the potential flaws in the IMerge study and the cautionary approach that must be used with any completely ...
by biopearl123
Mon Feb 19, 2024 12:09 am
Forum: ImetelChat
Topic: THANK YOU IMETELCHAT BOARD !!!!!
Replies: 19
Views: 2182

Re: THANK YOU IMETELCHAT BOARD !!!!!

👍
by biopearl123
Sun Feb 18, 2024 4:17 pm
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3985

Re: meanwhile, back on topic

Jay, I could be wrong but the way I read it is that these are options to buy stock at 2.10 anytime over the next ten years were awarded as a from of incentive/compensation. They own the options to buy. If the stock goes up it’s a bargain, they can buy at 2.10 if it goes down the options are worthles...
by biopearl123
Sun Feb 18, 2024 3:20 am
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3985

Re: meanwhile, back on topic

These are option awards with a 2034 expiration date.
by biopearl123
Sun Feb 18, 2024 12:32 am
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3985

Re: meanwhile, back on topic

Seedylemon, I think it might be worth trying to clarify your post. Dr. Scarlett along with other officers received option awards that can be exercised for a certain price anytime over the next ten years. That is not the same as buying shares outright or exercising options to guarantee a specific pri...
by biopearl123
Sat Feb 17, 2024 5:21 pm
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3985

Re: meanwhile, back on topic

Jay I have only seen recent options awarded but not redeemed. I probably missed the ones that were redeemed can you remind us? Thanks, bp
by biopearl123
Wed Feb 14, 2024 7:12 pm
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3985

Re: meanwhile, back on topic

Thanks Jay, course corrections always appreciated.
by biopearl123
Wed Feb 14, 2024 5:11 pm
Forum: ImetelChat
Topic: Will NOAA take action while the FDA stands on the sidelines?
Replies: 14
Views: 1873

Re: Will NOAA take action while the FDA stands on the sidelines?

Waddya mean you’d bet a dollar, you already owe me a dollar, oh wait maybe I owe you the dollar, can’t remember. Nevermind.
by biopearl123
Wed Feb 14, 2024 3:58 pm
Forum: ImetelChat
Topic: Will NOAA take action while the FDA stands on the sidelines?
Replies: 14
Views: 1873

Re: Will NOAA take action while the FDA stands on the sidelines?

Kmall, pretty sure Dr. Scarlett starts his day with a cup of coffee and a visit to this board. It is highly likely your concerns well be viewed by him and considered. He of all people has the means and interest.