Search found 409 matches

by biopearl123
Thu Jun 18, 2020 6:14 am
Forum: ImetelChat
Topic: Upcoming Phase 3 MF Trial
Replies: 4
Views: 1652

Re: Upcoming Phase 3 MF Trial

FC4364, Dr. Verstovek is verified as co lead investigator in Geron's presentation today. His CV is as CKTC has outlined. This is very good news and first class institutions are leading the way with Mt. Sinai and MD Anderson. bp
by biopearl123
Thu Jun 18, 2020 6:09 am
Forum: ImetelChat
Topic: Hindsight
Replies: 2
Views: 1027

Re: Hindsight

Gwickley, not sure what you mean but both Janssen and Dr. Scarlett estimate potential income in MF to be in that range. Also both kmall and Dr. Mascarenhas feel the actual numbers of cases are underestimated. bp
by biopearl123
Tue Jun 16, 2020 8:34 pm
Forum: ImetelChat
Topic: Message to Cathy
Replies: 0
Views: 872

Message to Cathy

Hi Cathy, I am troubled that you may have considered our last interaction to be less than cordial. Please know that was not my intention and I do apologize. When I agreed to be board moderator I set up some guidelines to ensure this board would not be another YMB, and perhaps I am too vigilant and s...
by biopearl123
Tue Jun 16, 2020 8:02 pm
Forum: ImetelChat
Topic: Sergei Gryzanov now CSO of MAIA
Replies: 2
Views: 1490

Re: Sergei Gryzanov now CSO of MAIA

Hi Bill, as always thank you for keeping this interesting topic on the front burner. Both Dr. Shay and Dr. Gryaznov (you should check your spelling) were great assets to Geron in their time. Given Dr. Gryaznov's status as father of Imetelstat, I have alway been surprised that he was not given a lab ...
by biopearl123
Tue Jun 16, 2020 7:25 pm
Forum: ImetelChat
Topic: Imagine reading this
Replies: 6
Views: 2009

Re: Imagine reading this

huntingonthe bluffs, thank you for your comments. Here is what our FDA has done to make blood more available (remember that blood is perishable and can not be stockpiled): https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-provides-updated-guidance-address-urgent-nee...
by biopearl123
Mon Jun 15, 2020 11:52 pm
Forum: ImetelChat
Topic: Hat tip to Joe Pipes YMB
Replies: 1
Views: 884

Re: Hat tip to Joe Pipes YMB

Dr. Platzbecker: "On target activity", "disease modification" , CR and CR+marrow CR. I think once the non medical financial community gets hold of this and recognizes the implications, we should see some serious appreciation. 68 % HI is in the words of Larry David is, "pretty pretty good". The scien...
by biopearl123
Mon Jun 15, 2020 10:43 pm
Forum: ImetelChat
Topic: Imetelstat
Replies: 1
Views: 811

Re: Imetelstat

Hi Jingle, it appears he didn’t stick around long enough to do much good. Maybe the atmosphere was too political or maybe the siren call of big money VC lured him away. bp
by biopearl123
Mon Jun 15, 2020 1:01 am
Forum: ImetelChat
Topic: Imagine reading this
Replies: 6
Views: 2009

Re: Imagine reading this

So after you read that, consider this. A little less than four years to approval and a lot more than 1 million interim blood transfusions, that's right more than 1 million at least, over that time period (this is probably an underestimate, someone check my math please--see previous posts). Well, I s...
by biopearl123
Sun Jun 14, 2020 9:59 pm
Forum: ImetelChat
Topic: Imagine reading this
Replies: 6
Views: 2009

Imagine reading this

Imagine reading this knowing you had to wait until 2024?

https://ashpublications.org/blood/artic ... y-Received

What does this say about our FDA
by biopearl123
Fri Jun 12, 2020 5:20 am
Forum: ImetelChat
Topic: By 2:30 AM Eastern time June 12th
Replies: 8
Views: 2656

Re: By 2:30 AM Eastern time June 12th

Yes but all he had to do was wait two weeks and raise at a higher stock price, that’s the part I don’t get.
by biopearl123
Thu Jun 11, 2020 7:02 pm
Forum: ImetelChat
Topic: By 2:30 AM Eastern time June 12th
Replies: 8
Views: 2656

By 2:30 AM Eastern time June 12th

By 2:30 AM Eastern time or shortly there after I hope the information from the oral MDS presentation will make its way into the public domaine. We already know from the abstract that the data is unique and exceeds results from any other drug in the clinic with regard to 8 week, 24 week and >1yr TI d...
by biopearl123
Tue Jun 09, 2020 11:12 pm
Forum: ImetelChat
Topic: The boxer and the timeline
Replies: 0
Views: 1290

The boxer and the timeline

First off thank you kmall for taking up the challenge of teaching us more about ligand trap and BET therapies. Look forward to your upcoming posts to learn more. Also CKTC, this topic is calling out for your first Imetelchat post! Well Dr. Scarlett has certainly shown us that he is a pro in the ring...
by biopearl123
Mon Jun 08, 2020 9:29 pm
Forum: ImetelChat
Topic: Thoughts from the shareholder meeting
Replies: 6
Views: 2043

Re: Thoughts from the shareholder meeting

Cathy, here is a good place to start. I love the last line of this article.

https://www.nature.com/scitable/topicpa ... mes-21041/
by biopearl123
Mon Jun 08, 2020 6:34 am
Forum: ImetelChat
Topic: Tone and the Power of Forgone Conclusions
Replies: 2
Views: 1153

Re: Tone and the Power of Forgone Conclusions

Lekola, Welcome to the board. We look forward to your contributions and hope one day you can grace us with a celebratory concert! Best Regards, bp
by biopearl123
Mon Jun 08, 2020 6:28 am
Forum: ImetelChat
Topic: Thoughts from the shareholder meeting
Replies: 6
Views: 2043

Re: Thoughts from the shareholder meeting

Hi Cathy, just a gentle reminder that personal comments should be avoided. I encourage all members to be respectful of others and suggest we avoid judging how others might view us but rather stick to posting the things we think are important to the board as we seek to educate ourselves. We are all i...
by biopearl123
Mon Jun 08, 2020 12:09 am
Forum: ImetelChat
Topic: Cathy's questions
Replies: 0
Views: 986

Cathy's questions

Please see previous post re Cathy's questions. To be fair, regarding value creating events, continuing and completed enrollment in both PIII studies certainly are value creating. The loss of the AML study is not. But unless there is a partner, a positive change in approval status or a buyout, it is ...
by biopearl123
Sun Jun 07, 2020 11:38 pm
Forum: ImetelChat
Topic: Questions for the upcoming shareholders meeting
Replies: 3
Views: 1691

Re: Questions for the upcoming shareholders meeting

Hi sure, I will give you my take. My opinions only, alternative views greatly appreciated and encouraged. When you assumed the helm at Geron you commented that the best time to sell a small biotech was when the company had accumulated good PII data. Since that now appears to have occurred, in conjun...
by biopearl123
Sun Jun 07, 2020 6:55 pm
Forum: ImetelChat
Topic: Additional thoughts
Replies: 7
Views: 1425

Re: Additional thoughts

ruccola, Unless some beacon of reason takes over at the FDA, Dr. Scarlett said (as an estimate--baring complication) to look for approval in early 2024. That's about 4 years from now. I suppose if the MDS study expands and becomes fully enrolled, top line data might be available before mid 2022. In ...
by biopearl123
Sun Jun 07, 2020 8:51 am
Forum: ImetelChat
Topic: Additional thoughts
Replies: 7
Views: 1425

Re: Additional thoughts

Kmall, it is shameful that the FDA overlooked the opportunity to make Imetelstat the RWD test case. Especially with molecular end point data.available also. Especially with hard evidence for fibrosis reversal. Especially with the ethics of having a no treatment control arm at this late stage in the ...