Search found 409 matches

by biopearl123
Thu Sep 20, 2018 2:07 pm
Forum: ImetelChat
Topic: Dr. Tefferi and patents
Replies: 1
Views: 1619

Re: Dr. Tefferi and patents

My recollection is that the Tefferi/Mayo patent was for dosing and indications not combo. Whether that patent would ever hold up in the face of Geron's extensive IP or was part of an agreement with Geron is open to question. bp
by biopearl123
Thu Sep 20, 2018 3:09 am
Forum: ImetelChat
Topic: Why Imbark gets approved
Replies: 7
Views: 5204

Re: Why Imbark gets approved

Salt rock, thank you for your kind words regarding this forum. Fortunately I have only rarely had to exercise my privilege as moderator regarding content and then only with warnings. I have thus far have not had to ever exercise censorship. (But I will if anyone tries to post irrelevancies or ad hom...
by biopearl123
Wed Sep 19, 2018 5:51 pm
Forum: ImetelChat
Topic: Why Imbark gets approved
Replies: 7
Views: 5204

Re: Why Imbark gets approved

Hi Phil, very nice synthesis and summary. Agree that all signs point to imminent MF approval. No plans for a phase III R/R study says a lot in a study that had to be extended because of the surprising extension of MOS. I imagine a front line study will follow but at least the drug would be on the ma...
by biopearl123
Mon Sep 17, 2018 6:16 pm
Forum: ImetelChat
Topic: The OTHER Janssen Agreement
Replies: 2
Views: 4035

Re: The OTHER Janssen Agreement

J6, thank you for calling this to the boards attention. I was always perplexed as to when Scarlett jettisoned the stem cell side that he also "appeared" to jettison Sergei, one who should be protected and revered, but clearly as we looked to see where he landed years ago it was a safe plac...
by biopearl123
Mon Sep 17, 2018 3:19 am
Forum: ImetelChat
Topic: SA Board comments
Replies: 1
Views: 1589

Re: SA Board comments

Gern2013, yes there are posters on both YMB and SA of dubious motivation but theses are counterbalanced by many well respected long standing posters. Its not hard to see who is who. Re the compassionate use list, either its a mistake or there has been a change in the drugs status that we are not pri...
by biopearl123
Sat Sep 15, 2018 4:25 am
Forum: ImetelChat
Topic: Study update
Replies: 5
Views: 2937

Re: Study update

Yes, there was most certainly a study update status but no details are provided. An optimist might conclude that it was related to impending approval but we don’t even know if a request for approval has even been filed yet. But we will soon. bp
by biopearl123
Fri Sep 14, 2018 6:48 pm
Forum: ImetelChat
Topic: Study update
Replies: 5
Views: 2937

Re: Study update

I think that’s an older change from Oct 2017 bp
by biopearl123
Fri Sep 14, 2018 4:40 pm
Forum: ImetelChat
Topic: Do NOT sell
Replies: 10
Views: 8411

Re: Do NOT sell

Great post Phil, many here would agree and for those who don’t, please post opposing views for discussion. Also note MF study update on CT site. bp
by biopearl123
Fri Sep 14, 2018 4:35 pm
Forum: ImetelChat
Topic: For those interested:Janssen Pharma presentation
Replies: 2
Views: 1999

Re: For those interested:Janssen Pharma presentation

Jpheis, agree totally, MF data much further along, no phase III planed etc, bp
by biopearl123
Thu Sep 13, 2018 2:32 am
Forum: ImetelChat
Topic: For those interested:Janssen Pharma presentation
Replies: 2
Views: 1999

For those interested:Janssen Pharma presentation

Sept 13th 10AM, here's the link: m We don't know for sure that Geron will even be mentioned by name but many hints abound not the least of which is that we are approaching a firm deadline for the CD from Janssen, and Janssen has emphasized a focus on heme related disease. Of course they have several...
by biopearl123
Tue Sep 11, 2018 3:31 am
Forum: ImetelChat
Topic: Geron can continue to provide a key part of the equation
Replies: 18
Views: 13007

Re: Geron can continue to provide a key part of the equation

Gwikley, after I wrote my post to you, I saw this on SA (reposted from YMB) so this poster seems to support your idea, here it is: Some guy on YMB said this: Robert Blake20 minutes ago Writing back on this board after long long time for a reason; The Job post is absolutely 100% BO. Place I work, whe...
by biopearl123
Tue Sep 11, 2018 3:11 am
Forum: ImetelChat
Topic: Geron can continue to provide a key part of the equation
Replies: 18
Views: 13007

Re: Geron can continue to provide a key part of the equation

Gwikley, A couple of thoughts, first of all welcome and thank you for posting. "Mr. Scarlett" is actually Dr. Scarlett and yes he has a history of selling companies and is well suited for his position. As near as I can tell, in my own opinion, he has done a stellar job, jettisoning the ste...
by biopearl123
Sun Sep 09, 2018 11:47 pm
Forum: ImetelChat
Topic: MM
Replies: 0
Views: 1755

MM

We have previously discussed the potential role of MM stem cells and the small clinical study done by the Matsui group that demonstrated a decrease in MM CSCs. Here is some suggestion that research in this area continues, which may be of interest to Janssen.

http://grantome.com/grant/NIH/R01-CA174951-05
by biopearl123
Sun Sep 09, 2018 3:15 am
Forum: ImetelChat
Topic: Janssen areas of highest focus
Replies: 0
Views: 1862

Janssen areas of highest focus

I think most have seen this on the Janssen site, for those who haven't, I am posting it here. Of interest is a relatively new area of cancer "interception". It seems likely that some change in the evolution/transformation of MDS (and the seeming unmentioned MF) seem to be occurring such th...
by biopearl123
Sun Sep 09, 2018 12:23 am
Forum: ImetelChat
Topic: Drum Roll thread for this week...
Replies: 1
Views: 1487

Re: Drum Roll thread for this week...

Hi Ryan, thank you for posting. I generally agree with what you have said and remain optimistic myself also. I would make one suggested clarification to your post however. The idea that OS can't be calculated is a little confusing. OS is overall survival, it can't be known until the last patient die...
by biopearl123
Fri Sep 07, 2018 6:13 am
Forum: ImetelChat
Topic: New review article
Replies: 2
Views: 1896

Re: New review article

Nerdy boy, thank you for posting actual link, I have been off trout fishing in Montana and was off the grid, I hoped someone would post the actual link based on my attempts at least to get the heads up posted. And so you did. Much appreciated, Thanks bp
by biopearl123
Fri Sep 07, 2018 6:05 am
Forum: ImetelChat
Topic: Censorship of relevant posts on the SA Board
Replies: 2
Views: 2163

Re: Censorship of relevant posts on the SA Board

Sargasso, your posts have never been censored on Imetelchat, I know others including Ed have had the same problem there. There is no robo screening here and I review every post. To my knowledge I have issued warnings (which were heeded) but have not actually had to censor any post. All ideas are wel...
by biopearl123
Thu Sep 06, 2018 6:08 am
Forum: ImetelChat
Topic: New review article
Replies: 2
Views: 1896

New review article

file:///C:/Users/arkie/Downloads/molecules-23-02267%20(4).pdf
Review
Oligonucleotides Targeting Telomeres and
Telomerase in Cancer

Hat tip, fear this raptor and hay flick