Search found 671 matches

by LWS
Sun Jun 23, 2024 3:50 pm
Forum: ImetelChat
Topic: Geron website says looking for partners
Replies: 6
Views: 997

Re: Geron website says looking for partners

As one looks back, it appears that Geron has been considering partners for a very long time. Also, potential partners had to worry about Rytelo being rejected by the FDA for numerous reasons categorized by (HI). That was not the case, as the FDA approval came through with 'flying-colors'. JS told u...
by LWS
Fri Jun 21, 2024 6:57 pm
Forum: ImetelChat
Topic: FDA Appreciation....
Replies: 2
Views: 1073

Re: FDA Appreciation....

The FDA has treated Rytelo much better than most thought possible. That bodes well for the future. HI -- As I see it, Rytelo passed through this very difficult obstacle course in perfect condition. These "safety-hurdles" were the ones that many feared. The safety issues for Rytelo seem resolved for...
by LWS
Wed Jun 19, 2024 5:05 pm
Forum: ImetelChat
Topic: Stealth Study Update
Replies: 8
Views: 1858

Re: Stealth Study Update

3 Thoughts about Rytelo's & Geron's future: 1/ AML 2/ IMpress (alone) & TELOMERE (combination with AbbVie) 3/ AbbVie (collaborator & possible partner) Note: The preclinical data could not be any better than "nearly 100% at 96 hours". This has been known for a longtime. The hesitation in pushing thi...
by LWS
Tue Jun 18, 2024 8:33 pm
Forum: ImetelChat
Topic: WE ARE APPROVED
Replies: 37
Views: 5626

Re: WE ARE APPROVED

Now that TELOMERE (AML clinical combination trial with Abbvie's Venetoclax and Rytelo) is getting back on track, it is time to take another look at the preclinical synergies (appear to be phenomenal -- near 100%). ============== Preclinical History for Review Reference Material ***Results (preclini...
by LWS
Tue Jun 18, 2024 6:27 pm
Forum: ImetelChat
Topic: There are many ways to think about partnering
Replies: 178
Views: 396264

Re: There are many ways to think about partnering

Now that Rytelo is an FDA approved blood cancer medicine with proven successes and vast potential going forward in all sorts of combinations, the thoughts of new partners are very much in focus. As a small biotech company, Geron needs the protection of a 'big brother' with deep pockets and worldwide...
by LWS
Tue Jun 18, 2024 4:08 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

"Game Changer", says Dr. Sekeres Some MDS patients likely have extended lifes from Rytelo, even though no formal study has been done. That is only my view, based upon the comments here. ============== Thanks Ryan & Kaz The approval by the Food and Drug Administration of Rytelo (imetelstat) for the ...
by LWS
Tue Jun 18, 2024 12:52 am
Forum: ImetelChat
Topic: WE ARE APPROVED
Replies: 37
Views: 5626

Re: WE ARE APPROVED

MDS and TI were the easiest hills to climb to get Rytelo FDA approved for something. Transfusion Independence is very important, but there are bigger fish to fry. That was the tip of the iceberg. Now the focus will be on MF and AML, alone (IMPress) and in combinations (TELOMERE with AbbVIe, a longt...
by LWS
Mon Jun 17, 2024 8:03 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

Thanks bp for the MF information. I had not seen this before. Unless I am missing something, this is very encouraging news. In the conclusions it states, "observed median OS that approached 30 months ". I wonder what the high points are. In the ODAC (MDS review) there was at least one patient that ...
by LWS
Mon Jun 17, 2024 6:20 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

bp --- Can you confirm or update the information below concerning MF (Rytelo) patients living longer? I don't believe that was a consideration in the recent (June 14th) MDS EHA paper, which was focused properly on transfusion independence and MDS. So far, I cannot find an English replay. One would ...
by LWS
Sun Jun 16, 2024 6:39 pm
Forum: ImetelChat
Topic: Principal Investigator Dr. Aleksandra M Stevens, MD, Phd
Replies: 4
Views: 1182

Re: Principal Investigator Dr. Aleksandra M Stevens, MD, Phd

Reviewing TELOMERE (combination for AML) for myself and the many new users of this Chatroom. The major difference now is that Rytelo (Imetelstat) is an approved medicine and can be used with other approved medications. TELOMERE has been on hold, but now it looks like it has new life. This is an ext...
by LWS
Sun Jun 16, 2024 2:37 am
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

bp --- As you suggest, the discussions about longer survival times must be from the ongoing MF trial. If you have some of those comments, I would like to see them again (for reference). My list was meant to be goals beyond transfusion independence (the critical approval factor that will allow for n...
by LWS
Sat Jun 15, 2024 8:29 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

bp -- Overall Survival Time Reviewed -- always a consideration I believe in other ongoing trials or completed trials there has been discussion of documented longer survival times. However, I am basing that on memory. I will look at past discussions. Any inputs would be appreciated. I am almost sure...
by LWS
Sat Jun 15, 2024 2:39 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

Last week Imetelstat (experimental), this week Rytelo (commercial), next week (???) The FDA had not been compromised, and approval was granted with minimal restrictions, as far as I can tell. The EHA oral presentation was yesterday. I am still looking for the replay (especially the Q & A). Now off ...
by LWS
Fri Jun 14, 2024 5:57 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

This is all that I could find. Please post as information becomes available. ================================================================== Copilot Certainly! The European Hematology Association (EHA) Conference is an exciting event for professionals in the field. On June 14th, there will be an...
by LWS
Thu Jun 13, 2024 4:19 pm
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 12
Views: 5849

Re: EHA Abstracts

June 14, 2024 --- Tomorrow is the first day that Rytelo, now as an FDA approved medicine, can be talked about openly at a major, important conference (EHA -- European Hematology Association in Madrid). Dr. Valeria (backed up by many blood cancer experts from all over the world) will be the presente...
by LWS
Wed Jun 12, 2024 3:14 am
Forum: ImetelChat
Topic: WE ARE APPROVED
Replies: 37
Views: 5626

Re: WE ARE APPROVED

With Rytelo approved, Geron can go in many directions now with big pharma, deep pocketed backing. Here are some items to reconsider with an approved medicine. When will there be new partners or a buyout? ================= Previous Imetelstat is now making the medical news in many ways, including AS...
by LWS
Tue Jun 11, 2024 4:38 pm
Forum: ImetelChat
Topic: PPS
Replies: 111
Views: 160259

Re: PPS

Blackburn's original Nobel Prize had to do with telomeres, telomerase and the aging process . The cancer considerations came later when Geron applied Rytelo successfully to ET (a blood cancer) which was followed by Dr. T at Mayo Clinic (more surprises and more blood cancers). Many patents, with eve...
by LWS
Mon Jun 10, 2024 11:59 pm
Forum: ImetelChat
Topic: PPS
Replies: 111
Views: 160259

Re: PPS

Thoughts & Open Questions--- I don't believe that we know much about IP and patents. MD Anderson (collaborates with Geron) and the U of Texas Medical Center (licensed THIO to MAIA) are closely connected. Geron, MAIA, MD Anderson, U of Texas Medical Center may all be working together, under the rada...
by LWS
Mon Jun 10, 2024 7:27 pm
Forum: ImetelChat
Topic: PPS
Replies: 111
Views: 160259

Re: PPS

The comparisons continue now that Rytelo is FDA approved. =========================== NYSE American - Nasdaq Real Time Price•USD MAIA Biotechnology, Inc. (MAIA) Following 3.86000.0000(0.00%) As of 1:15 PM EDT. Market Open. Closed at 3.96 ================ NasdaqGS - Nasdaq Real Time Price•USD Geron ...
by LWS
Mon Jun 10, 2024 4:31 pm
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 12
Views: 5849

Re: EHA Abstracts

EHA -- With Dr. Santini leading the charge, the newly approved Rytelo will be introduced to the world . We will all be very interested in the leading subject of this oral presentation, Overall Survival (June 14th I believe). With approval, various procedures can now be considered (off label, combin...