Search found 595 matches

by LWS
Wed Apr 17, 2024 7:43 pm
Forum: ImetelChat
Topic: Stifel Presentation Today
Replies: 1
Views: 343

Re: Stifel Presentation Today

We are all waiting for the formal approval of Imetelstat. As far as I can tell from John Scarlett's comments, everything is on track and ready to go. ODAC recommends (12 YES votes from blood cancer experts, 2 No votes) and the FDA approves. I don't believe that there has ever been any deviation from...
by LWS
Wed Apr 17, 2024 6:43 pm
Forum: ImetelChat
Topic: RYTELO
Replies: 4
Views: 1505

Re: RYTELO

Stifel Oncology Forum today very positive (replay now available). #1 take away (beyond transfusion independence) --- "Dynamic Increase of Hemoglobin".
by LWS
Tue Apr 16, 2024 12:49 am
Forum: ImetelChat
Topic: PPS
Replies: 81
Views: 135771

Re: PPS

As investors, now is the time to focus on the PPS. The uniqueness of Rytelo (imetelstat) as a treatment for blood cancers (starting with transfusion independence) is just beginning to be understood as very beneficial now (by itself) and as a treatment, building component, research tool, and in some...
by LWS
Mon Apr 15, 2024 4:23 pm
Forum: ImetelChat
Topic: RYTELO
Replies: 4
Views: 1505

Re: RYTELO

FOSTER CITY, Calif.--(BUSINESS WIRE) -- Geron Corporation (Nasdaq: GERN), a late-stage clinical biopharmaceutical company, announced that John A. Scarlett, M.D., Geron’s Chairman and Chief Executive Officer, is scheduled to present at the following virtual investor conferences: Stifel’s 2024 Virtua...
by LWS
Fri Apr 12, 2024 4:08 pm
Forum: ImetelChat
Topic: PPS
Replies: 81
Views: 135771

Re: PPS

I believe we can finally concentrate on the PPS. ODAC has spoken and the FDA always accepts their positive, overwhelmingly good recommendations (12 yes including blood cancer experts, 2 no ). I believe we are close to $4 PPS, and moving higher. Off-label uses will come into focus. =================...
by LWS
Thu Apr 11, 2024 5:11 pm
Forum: ImetelChat
Topic: RYTELO
Replies: 4
Views: 1505

Re: RYTELO

There is no medicine that does what Rytelo (imetelstat) can do as a stand alone medicine (transfusion independence, improved quality of life, longer life, disease modification, remissions, etc.). On approval (now a formality) off label uses will be suggested and tested. High on the list will be chem...
by LWS
Mon Apr 08, 2024 6:37 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 35
Views: 9407

Re: FDA v. Geron

In the case of ODAC (Oncology Drug Advisory Committee) when they recommend positively and overwhelmingly (12 Yes to 2) the FDA has NEVER rejected their expert advise. I know of no blood cancer oncologist that has spoken against RYTELO (Imetelstat). Many have spoken publicly on its behalf. NOTE: Of ...
by LWS
Sat Apr 06, 2024 10:36 pm
Forum: ImetelChat
Topic: RYTELO
Replies: 4
Views: 1505

Re: RYTELO

MIAMI, FLORIDA (March 14, 2024) – Dr. Mikkael Sekeres is an expert in blood cancers at Sylvester Comprehensive Cancer Center - University of Miami Health System. He served on the Oncologic Drugs Advisory Committee (ODAC) for the trial that led to imetelstat vote of support at the FDA today. Imetels...
by LWS
Sat Apr 06, 2024 7:04 pm
Forum: ImetelChat
Topic: 12-2, take the win right?
Replies: 9
Views: 3312

Re: 12-2, take the win right?

We know exactly what will happen. ODAC has recommended Imetelstat (March 14th) and the FDA always accepts overwhelmingly positive votes (12 YES votes from blood cancer oncologists, 2 NO votes from others). This is not controversial. Imetelstat kills cancer stem-cells in 2 ways and is needed now by ...
by LWS
Fri Apr 05, 2024 7:14 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 35
Views: 9407

Re: FDA v. Geron

The Chair (Ravi) was not up to speed on the importance of Imetelstat to the blood cancer world as a vital 'tool' in transfusion control and well beyond (quality of life, increased survival time, disease modification, combinations, hemoglobin increases ). I suspect he is there by now. ==============...
by LWS
Thu Apr 04, 2024 4:02 pm
Forum: ImetelChat
Topic: More JnJ Trouble on The Horizon?
Replies: 1
Views: 531

Re: More JnJ Trouble on The Horizon?

Turn off the SUN. It causes cancer. The alternatives are difficult to find. Many things cause cancer if you get too much. What is a safe level? (benefit vs. risk again) New, more sensitive sensors are always being invented.
by LWS
Tue Apr 02, 2024 6:47 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 35
Views: 9407

Re: FDA v. Geron

Imetelstat is a breakthrough blood cancer medicine that works for many today, and has almost unlimited potential (kills cancer stem-cells in two ways) in combinations going forward. The 12 YES, 2 NO votes was 100% favored by the ODAC oncology hematologists. “ While  a  significant  minority  of  pa...
by LWS
Sun Mar 31, 2024 6:14 pm
Forum: ImetelChat
Topic: 12-2, take the win right?
Replies: 9
Views: 3312

Re: 12-2, take the win right?

The benefits of Imetelstat out weigh the risks (not even close) All of the important negatives are temporary and reversible for both responders and non-responders. Obviously, more research is required (partners are a consideration), but that is not a reason to deny it to those who can benefit today...
by LWS
Fri Mar 29, 2024 8:33 pm
Forum: ImetelChat
Topic: Hundreds of views every day
Replies: 3
Views: 1147

Re: Hundreds of views every day

The Die is Cast Certainly, JS knows more than he is telling us about partners and buyouts. There seems to be a 'Geron-factor' (some would say, a 'Geron-curse') with a level of uncertainty that is holding the PPS at these levels. CKTC found 2 cases (ODAC recommended, FDA rejected). If possible (curi...
by LWS
Wed Mar 27, 2024 3:33 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 35
Views: 9407

Re: FDA v. Geron

It very unlikely that the FDA would reject their ODAC's recommendation for approving Imetelstat. Still we are a bit nervous about the FDAs "devil's advocates" comments (March 14) and the (NO) vote of the chairperson. The FDA has much on its table these days, as their past and future is now being re...
by LWS
Wed Mar 27, 2024 12:08 am
Forum: ImetelChat
Topic: Down the road, way down the road
Replies: 5
Views: 1386

Re: Down the road, way down the road

I will refer to him as Dr. Smith. To me, the subject of interest is the "litigation economics" and the fact that Sergei (Dr. Sergei Gryaznov, now at MAIA)) spent so much time with both companies developing Imetelstat and THIO as important cancer medicines. Which patents, with his name belong to Ger...
by LWS
Tue Mar 26, 2024 9:41 pm
Forum: ImetelChat
Topic: Down the road, way down the road
Replies: 5
Views: 1386

Re: Down the road, way down the road

jay --- Most men that I know with PhDs, that do not have medical degrees, prefer to be called (Mr.) . The interesting thing about Mr. Smith, is that his background is litigation economics. Assuming that the FDA does not create some last-minute difficulty with the NDA approval and takes ODAC's posit...
by LWS
Tue Mar 26, 2024 4:03 pm
Forum: ImetelChat
Topic: Down the road, way down the road
Replies: 5
Views: 1386

Re: Down the road, way down the road

News about Dr. Stan Smith (Will patent considerations bring Geron and MAIA together in some form of collaboration?) ============ MAIA Biotechnology Announces Share Purchase by Director Stan Smith, PhD in a $2.9 Million Private Placement March 22, 2024 3:00 PM EDT Tweet Share E-mail Dr. Smith has pa...
by LWS
Sat Mar 23, 2024 11:29 pm
Forum: ImetelChat
Topic: Sergei Left a comment on LinkedIn
Replies: 2
Views: 1221

Re: Sergei Left a comment on LinkedIn

Some History for those that are new to this board ======================== Posted Dec. 27, 2023 Telomerase Inhibitors for Potentially 90% of all Cancers MD Anderson and the University of Texas medical unit are already partners. They are building the ulitmate cancer research and treatment center in ...
by LWS
Fri Mar 22, 2024 6:06 pm
Forum: ImetelChat
Topic: Sergei Left a comment on LinkedIn
Replies: 2
Views: 1221

Re: Sergei Left a comment on LinkedIn

I am sure Sergei is very happy. MAIA is getting a very strong tail-wind from Imetelstat's very positive ODAC recommendation. Some have previously suggested that there are overlapping patents. It would make both good business sense and good medical sense for both companies (Geron and MAIA) to find a...