Search found 630 matches

by LWS
Thu May 23, 2024 6:59 pm
Forum: ImetelChat
Topic: Disease Modification and OS
Replies: 3
Views: 940

Re: Disease Modification and OS

Remember the EAP (Expanded Access Program) is still in place. John Scarlett said that this was equivalent to a phase 4 trial. Surely, some have taken advantage of this availability. This is a continuous source of data as we wait for the FDA to speak. We all expect approval (sans shenanigans & conspi...
by LWS
Wed May 22, 2024 11:33 pm
Forum: ImetelChat
Topic: Disease Modification and OS
Replies: 3
Views: 940

Re: Disease Modification and OS

It is a strange world that we live in. I cannot imagine any reason that the FDA would "deep-six" Imetelstat after all of the positive news in trials, conferences and from blood cancer experts. We have only seen the abstract of the EHA presentation. Considering the presenter (Valeria Santini) and th...
by LWS
Wed May 22, 2024 3:53 pm
Forum: ImetelChat
Topic: PPS
Replies: 98
Views: 142703

Re: PPS

The connection between MAIA and Geron has a very long history (tied to each other by Sergei & patent considerations ). Geron's successes are reflected by MAIA's PPS. ================ NasdaqGS - Nasdaq Real Time Price•USD Geron Corporation (GERN) Following 3.6750-0.0250(-0.6766%) As of 9:45 AM EDT. ...
by LWS
Mon May 20, 2024 10:55 pm
Forum: ImetelChat
Topic: Disease Modification and OS
Replies: 3
Views: 940

Re: Disease Modification and OS

Once we get Imetelstat approved for something (such as TI before June 16) more theories about how and why this medicine works will evolve. Disease modification (including TI, OS, hemoglobin levels, quality of life, killing cancer stem cells (2 ways), etc.) from Imetelstat is apparently one major pro...
by LWS
Mon May 20, 2024 4:28 pm
Forum: ImetelChat
Topic: The thing about OS
Replies: 2
Views: 886

Re: The thing about OS

Focusing on Overall Survival (OS) Time This pending NDA deals with Transfusion Independence (TI), but there were other considerations at ODAC (March 14). OS, of all of the parameters, appears to be the most important. As I remember, OS has been very impressive in several of the ongoing trails. We h...
by LWS
Sat May 18, 2024 7:12 pm
Forum: ImetelChat
Topic: Interesting timeline (as we wait)
Replies: 1
Views: 866

Re: Interesting timeline (as we wait)

All we can do is wait. Most of us (on this board) believe that Geron's NDA for Imetelstat will be granted (very high probability). Still, no one has been able to explain the FDA's opening diatribe on March 14th, which was totally refuted by most of ODAC and other contributors (patients, blood cance...
by LWS
Fri May 17, 2024 6:23 pm
Forum: ImetelChat
Topic: Inducement Grants
Replies: 4
Views: 1001

Re: Inducement Grants

Dr. Feller told us (shareholders meeting, May 9th) that Geron was in the process of increasing its staff from 162 to between 250 and 300. These inducements would be consistent with that goal. I cannot imagine this kind of rapid expansion, unless they were sure that the 12 to 2 ODAC recommendation wa...
by LWS
Thu May 16, 2024 4:52 pm
Forum: ImetelChat
Topic: Institutional Ownership = 75.7%
Replies: 1
Views: 685

Re: Institutional Ownership = 75.7%

As I have been cautioned several times, nothing is a sure thing until the 'fat lady sings' (in this case the FDA). All appears to be in place for the FDA to approve Geron's NDA for Imetelstat (transfusion independence, EHA paper, institutional ownership, blood cancer experts, ODAC recommendation, e...
by LWS
Wed May 15, 2024 4:34 pm
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 8
Views: 2665

Re: EHA Abstracts

Interesting how the subjects are listed in the title: 1/ OVERALL SURVIVAL 2/ CLINICAL BENEFIT 3/ DURABLE TRANSFUSION INDEPENDENCE This could be considered a list of important successes, with overall survival time and the quality of life (clinical benefit -- fatigue, feeling good, disease modificati...
by LWS
Tue May 14, 2024 6:01 pm
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 8
Views: 2665

Re: EHA Abstracts

EHA Abstract (Many authors) ============ OVERALL SURVIVAL, CLINICAL BENEFIT, AND DURABLE TRANSFUSION INDEPENDENCE WITH IMETELSTAT IN THE IMERGE PHASE 3 TRIAL OF RED BLOOD CELL-TRANSFUSION DEPENDENT LOWER-RISK MYELODYSPLASTIC SYNDROMES Prof. Valeria Santini Author(s): Valeria Santini, Rami S. Komrok...
by LWS
Mon May 13, 2024 7:14 pm
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 8
Views: 2665

Re: EHA Abstracts

Dr. Feller (Recording of Virtual Shareholders meeting -- May 9th) emphasized the importance of "no leaks" concerning the EHA abstracts. Geron's employee count is going from 162 to between 250 and 300. We can be certain that there will be important and interesting presentations concerning Imetelstat ...
by LWS
Sat May 11, 2024 6:03 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 45
Views: 13309

Re: FDA v. Geron

Let's get Imetelstat over the finish line. It is now a binary decision, either the FDA approves (most likely) or the FDA denies. Denial would be a surprise considering 12 YES ODAC votes. Also, the integrity of the FDA would be questioned. The FDA (as far as I can tell) has never rejected an ODAC po...
by LWS
Sat May 11, 2024 4:07 am
Forum: ImetelChat
Topic: My shareholder questions (with answers)
Replies: 7
Views: 1187

Re: My shareholder questions (with answers)

To KTA -- May I point out that ImetelChat is a chatroom that is designed for science, medical progress and opinions based upon future projections. It not designed to be a scientific journal on the high end or a place for a character assassin on the low end as you are using it on the low end. Your l...
by LWS
Sat May 11, 2024 1:18 am
Forum: ImetelChat
Topic: My shareholder questions (with answers)
Replies: 7
Views: 1187

Re: My shareholder questions (with answers)

By the short run, I mean the time between today and June 16th. I am hoping that Imetelstat gets approved in that timeframe. If it does not the future of Geron will be very much in doubt after years of successful trails and meeting patients' unmet needs. I believe the FDA will approve, but the FDA's...
by LWS
Sat May 11, 2024 12:44 am
Forum: ImetelChat
Topic: My shareholder questions (with answers)
Replies: 7
Views: 1187

Re: My shareholder questions (with answers)

The Die is Cast on or before June 16th It now a binary decision, either the FDA approves (most likely) or the FDA denies. Denial would be a surprise considering 12 YES ODAC votes. Also, the integrity of the FDA would be questioned. Geron (obviously) is a one drug company at this point in time. Imet...
by LWS
Thu May 09, 2024 5:30 pm
Forum: ImetelChat
Topic: 12-2, take the win right?
Replies: 13
Views: 6250

Re: 12-2, take the win right?

The 12 YES votes from ODAC should prevail. No one trusts the FDA after their "devil's advocate" presentation at ODAC's March 14th meeting. Some think there is an "effort" by big pharma to prevent FDA approval of Imetelstat and that is holding the price down. It could shoot up rapidly (toward $10 as...
by LWS
Thu May 09, 2024 1:00 am
Forum: ImetelChat
Topic: Upcoming Events....
Replies: 10
Views: 2581

Re: Upcoming Events....

Tomorrow's (May 9) shareholder meeting may present more information for us to dissect. I don't see anything preventing Imetelstat's NDA approval, that is honest and above board. (No shenanigans or conspiracies that are credible) Anything is possible in the world of Geron. However, as far as I can t...
by LWS
Mon May 06, 2024 8:12 pm
Forum: ImetelChat
Topic: PPS
Replies: 98
Views: 142703

Re: PPS

PPS of Geron almost = to PPS of MAIA ======================== NYSE American - Nasdaq Real Time Price•USD MAIA Biotechnology, Inc. (MAIA) Following 3.3900+0.1100(+3.3537%) As of 2:05 PM EDT. Market Open. ===================== NasdaqGS - Nasdaq Real Time Price•USD Geron Corporation (GERN) Following 3...
by LWS
Fri May 03, 2024 11:47 pm
Forum: ImetelChat
Topic: Sergei Left a comment on LinkedIn
Replies: 5
Views: 3236

Re: Sergei Left a comment on LinkedIn

We cannot separate Geron from MAIA at this point in time. There is too much common history between them with similar goals. I believe both companies will be successful as important factors in the development of treatments and cures for a variety of cancers --- the whole spectrum from the simplest o...
by LWS
Fri May 03, 2024 6:15 pm
Forum: ImetelChat
Topic: PPS
Replies: 98
Views: 142703

Re: PPS

For whatever reason, money (at the moment) is flowing out of Geron and into MAIA (tied to each other by Sergei & patent considerations). What is happening at MAIA (solid cancers with delivery systems) that appears to be so interesting? Does a Geron approval from the FDA open the doors for MAIA to g...