Search found 109 matches

by KTArsenal
Sat May 11, 2024 2:59 am
Forum: ImetelChat
Topic: My shareholder questions (with answers)
Replies: 7
Views: 1187

Re: My shareholder questions (with answers)

Many investors on this board have years--some decades worth of building a position in Geron and imetelstat. It's never been the short game, ever. In fact, the timeline to MDS application increased on accident from COVID by a year. Your poor wording could appear to debase years of research and invest...
by KTArsenal
Sat May 11, 2024 1:02 am
Forum: ImetelChat
Topic: My shareholder questions (with answers)
Replies: 7
Views: 1187

Re: My shareholder questions (with answers)

It's never been a "short run" with imetelstat.

Please take that entire paragraph that you wrote and either:

A.) Shoot it dead

B.) Kill it with fire, or

C.) Press the delete button like you've just hit multiball on your favorite pinball machine.
by KTArsenal
Thu May 02, 2024 10:18 pm
Forum: ImetelChat
Topic: Upcoming Events....
Replies: 10
Views: 2580

Re: Upcoming Events....

When LWS visits their favorite restaurant, their go-to order must be: Overcooked copypasta and meatballs. Meatballs are extremely overdone and also not a lot of meat in the ingredients. Extra filler. For dessert, it's gonna be warm (parenthetical) pie served with a scoop of vanilla. Not ice cream, j...
by KTArsenal
Sun Apr 28, 2024 7:53 am
Forum: ImetelChat
Topic: PPS
Replies: 98
Views: 142698

Re: PPS

We don't want to lose LWS. Their sleuthiness and sleuthy sleuthing is superior to many sleuthy sluethers that are *trying* to be sleuthy sleuthers like LWS, yet they cannot sleuth like true sleuthing sluethers sleuth like LWS sleuths. Lame sleuths, pretending to be sleuthy sleuthers yet cannot sleut...
by KTArsenal
Fri Apr 26, 2024 10:56 pm
Forum: ImetelChat
Topic: PPS
Replies: 98
Views: 142698

Re: PPS

Thanks for the update.

There's no way we could attain that information without your stealthy sleuthing.
by KTArsenal
Sat Apr 20, 2024 12:26 am
Forum: ImetelChat
Topic: PPS
Replies: 98
Views: 142698

Re: PPS

Let's discuss the (PPS increase) elephant in the room (from a 30-day post-ODAC perspective) with a David Letterman Top 10 list: {snare roll} 10. Bad news disguised as good news. 9. The only thing "baked-in" occurs on 4-20. 8. Shaking the retail tree seems to be not much more than a sapling. 7. Decre...
by KTArsenal
Thu Mar 21, 2024 12:53 am
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 45
Views: 13309

Re: FDA v. Geron

If 12-2 doesn't hold any weight, then the moon is made of cheese.
by KTArsenal
Sun Mar 17, 2024 6:35 pm
Forum: ImetelChat
Topic: Vote 12-2 in Favor
Replies: 9
Views: 2419

Re: Vote 12-2 in Favor

Similar to a priority review pathway, an unmet need usually addressed by orphan products tends to increase the likelihood of approval.

Paraphrasing here, but you get the point.

Pink.citeline.com was used for this sourcing material.
by KTArsenal
Fri Mar 15, 2024 10:12 am
Forum: ImetelChat
Topic: Giving Thanks to Fish Jr, Biopearl, Kmall & company
Replies: 2
Views: 988

Re: Giving Thanks to Fish Jr, Biopearl, Kmall & company

Well written, well said.

Not too much to add except for yes.

Thanks, guys.
by KTArsenal
Fri Mar 15, 2024 12:36 am
Forum: ImetelChat
Topic: March 14th
Replies: 27
Views: 6122

Re: March 14th

Cheers to a nice medium-brew coffee and a bagel with cream cheese or butter and lox. Whatever!

Shots of espresso all around!
by KTArsenal
Fri Mar 15, 2024 12:15 am
Forum: ImetelChat
Topic: Dr. Feller
Replies: 0
Views: 1039

Dr. Feller

With all of the negative talk surrounding the abrupt departure of triple Dr. Rizo, it's COMPLETELY apparent that Dr. Feller was an easy choice to replace Dr. Rizo's unenviable position as CMO for Geron. She's a goddamned gem. Well spoken (unlike myself), brilliantly adept at explaining the CT data, ...
by KTArsenal
Thu Mar 14, 2024 10:45 pm
Forum: ImetelChat
Topic: March 14th
Replies: 27
Views: 6122

Re: March 14th

I think shots are in order.

12-2 should definitely be shots in order.

What's your flavor?
by KTArsenal
Thu Mar 14, 2024 7:00 pm
Forum: ImetelChat
Topic: March 14th
Replies: 27
Views: 6122

Re: March 14th

Again, I believe the FDA *has* to be heavy-handed in regards to efficacy and safety profile.

After all of the human MDS stories using imetelstat and doctor's approvals for using imetelstat, this committee would be ghoulish to not approve imetelstat for a therapeutic option in MDS.

Period.
by KTArsenal
Thu Mar 14, 2024 6:23 pm
Forum: ImetelChat
Topic: March 14th
Replies: 27
Views: 6122

Re: March 14th

I believe--could be wrong--it's faster to approval here in the U.S. than it is abroad, believe it or not. That's one scenario.

I think the other is the FDA is the "gold standard" for a drug's approval process. Unless you're big pharma, and then it's basically a rubber stamp from the FDA.
by KTArsenal
Thu Mar 14, 2024 5:25 pm
Forum: ImetelChat
Topic: March 14th
Replies: 27
Views: 6122

Re: March 14th

The safety review team never cancelled one MDS clinical trial, either. I've got to believe that the FDA has to be hyper-critical and overly dramatic concerning safety and efficacy with a new molecule applying for an NDA. So far, Dr. Feller is just so good. If we get an approval nod from this committ...
by KTArsenal
Thu Mar 14, 2024 4:43 pm
Forum: ImetelChat
Topic: March 14th
Replies: 27
Views: 6122

Re: March 14th

Yep, the very first FDA presenter was visibly nervous and her voice was incredibly shaky.

Faye Feller is just an incredible orator. She's a home run hitter.
by KTArsenal
Wed Mar 13, 2024 10:13 pm
Forum: ImetelChat
Topic: CKTC
Replies: 8
Views: 2034

Re: CKTC

I'd like to inject this entire thread directly into my veins.

Thanks for everything, even if we come up short. Cheers 🍻
by KTArsenal
Wed Mar 13, 2024 10:10 pm
Forum: ImetelChat
Topic: Basic Considerations....
Replies: 13
Views: 2816

Re: Basic Considerations....

Links don't work.

What's your synopsis on those dead space links?
by KTArsenal
Wed Mar 13, 2024 12:04 am
Forum: ImetelChat
Topic: Risk vs. Benefit
Replies: 6
Views: 1808

Re: Risk vs. Benefit

Which Geron experts do we expect to speak on the behalf of imetelstat? So far, Dr. Hunter can be ASSURED he's there as an imetelstat detractor, and for me, that's plainly obvious, if he's on the ADCOM review board. Let's hope that this committee's questions about imetelstat's safety and efficacy are...
by KTArsenal
Tue Mar 12, 2024 11:16 pm
Forum: ImetelChat
Topic: Risk vs. Benefit
Replies: 6
Views: 1808

Re: Risk vs. Benefit

Will the panel also include patients who did not benefit from imetelstat, and will they be able to cry wolf due to lack of efficacy and cytopenias? I feel like the FDA might have the upper hand in this Big Pharma chess game. Let's be honest: The FDA is basically stating that Geron cooked the efficac...