Search found 60 matches
- Fri Mar 15, 2024 9:45 pm
- Forum: ImetelChat
- Topic: Quite Surprising that....
- Replies: 10
- Views: 2880
Re: Quite Surprising that....
The second no was from a Statistician. Interesting - since the primary and secondary end points were met. Yet the stats expert voted No. A conundrum. If the recommendation is a NO after previously agreed upon endpoints are met ‐ how will the pharma industry ever develop drug? What is the point of ag...
- Thu Mar 14, 2024 8:23 pm
- Forum: ImetelChat
- Topic: March 14th
- Replies: 27
- Views: 5639
Re: March 14th
12 yes
2 no
2 no
- Thu Mar 14, 2024 8:21 pm
- Forum: ImetelChat
- Topic: March 14th
- Replies: 27
- Views: 5639
Re: March 14th
Very entertaining... worst fear than any horror movie I have seen. Would have been perfect... except this is real life, impacting real patients and real families.
I am ashamed at the incompetent FDA members and the panelist who voted no. May their family and friends never get this disease.
I am ashamed at the incompetent FDA members and the panelist who voted no. May their family and friends never get this disease.
- Fri Feb 09, 2024 12:43 am
- Forum: ImetelChat
- Topic: FDA v. Geron
- Replies: 35
- Views: 9627
Re: FDA v. Geron
Concur. I don't think this is FDA vs. Geron. Rather, I think it may be a symptom of "measure twice, cut once". IF we go back in time, ... VEGF, Avastin, etc... the development process was very challenging. New MoA, unknown long term effects, and potential broad spectrum use. I would suspect that onc...
- Wed Nov 22, 2023 10:20 am
- Forum: ImetelChat
- Topic: An open inquiry..
- Replies: 5
- Views: 6965
Re: An open inquiry..
So i am, similar to other folks, who have used chat.openai.com, am tremendously impressed. No two ways that it is a big step in the right direction of more intelligent machines, and better processing of data. For writing poems, or searching contents - it's a tremendous time saver. However, we have t...
- Wed Oct 04, 2023 3:28 pm
- Forum: ImetelChat
- Topic: Smart Dumb Money and PPS
- Replies: 0
- Views: 13267
Smart Dumb Money and PPS
All Saw the movie "Dumb Money" last night. Anyone concerned with GERN stock price... should most certainly watch that movie. The movie is about the GAMESTOP company and stock, but I believe that in nutshell, the resemblance to Geron may be relatively obvious. Good luck to us about next few months...
- Fri Feb 17, 2023 4:39 pm
- Forum: ImetelChat
- Topic: Is a defense against shorts possible?
- Replies: 1
- Views: 792
Is a defense against shorts possible?
GERN share stats Total shares outstanding - 450M, give or take. Average volume of trades shares - between 4 - 8 million shares (1-2%) Short positions - 5%. Source; yahoo finance. So the question is... what if any defense is even possible? Remember that shorts could have accumulated the shares back w...
- Tue Feb 07, 2023 1:58 am
- Forum: ImetelChat
- Topic: Old Tricks vs. New Realities.
- Replies: 1
- Views: 963
Old Tricks vs. New Realities.
Thought I would share my 2 cents on the prior discussion about GERON up to its old tricks again, especially with the delayed trials...etc. Of course a disclaimer, it is difficult to speculate from the outside, but what the heck...its fun to just explore realms of possibility. So here it goes... =-==...
- Thu Jan 05, 2023 3:06 pm
- Forum: ImetelChat
- Topic: Hat tip to JC YMB
- Replies: 1
- Views: 833
Re: Hat tip to JC YMB
Absolutely... and not to mention the proverbial... dig well BEFORE YOU ARE THIRSTY philosophy. In this case... having option to raise funds and commercialize our, OUR, own drug (THANK YOU JNJ) is incredibly powerful during negotiations with potential partners. So as investor we take short term hit o...
- Fri Dec 30, 2022 6:28 pm
- Forum: ImetelChat
- Topic: Don't want to make waves
- Replies: 5
- Views: 1591
Re: Don't want to make waves
All This is not an accurate sentiment in my opinion. Assume that this is a $365 M dollar revenue molecule. This means even a day delay is a million dollar impact. Furthermore if the message - commercial or marketing or same or payer/ value e.t.c is sub-optimal, the long term impact is high. And heav...
- Wed Dec 21, 2022 10:07 pm
- Forum: ImetelChat
- Topic: Hypothesis around reduced Focus on partnership
- Replies: 1
- Views: 535
Hypothesis around reduced Focus on partnership
I am on a vacation with limited voluntary work or outside connections... so pardon specificity. However some recent postings have suggested frustration regarding reduced emphasis on partnering. Similarly, lack of such deal, especially with senior leaders in the company rightfully and logically raise...
- Mon Nov 14, 2022 9:42 pm
- Forum: ImetelChat
- Topic: Why Dr. Scarlett and Co. are smiling
- Replies: 3
- Views: 1573
Re: Why Dr. Scarlett and Co. are smiling
How I wish I could see and visually assess Dr. Scarlett's confidence (and smile) tomorrow - as they present at Stifel 2022 Healthcare Conference in New York City on Tuesday, November 15, 2022 at 10:55 a.m. ET
- Wed Oct 19, 2022 1:10 am
- Forum: ImetelChat
- Topic: One year mark
- Replies: 2
- Views: 834
Re: One year mark
My predictions: 1. We may see movement on the UK regulatory front... now that the P3 data can be unblinded. 2. We may likely see the Top Line Results within next 45 days. Especially if the data has been cleaned up along the way, and database is ready for locking soon. 3. We may see regulatory action...
- Sun Jul 03, 2022 9:32 pm
- Forum: ImetelChat
- Topic: Additional thoughts…musings on the expansion of loan
- Replies: 3
- Views: 1649
Re: Additional thoughts…musings on the expansion of loan
An hypothesis.
Why expanded Loan NOW!
we have known that the interest rates are going up soon... why not exercise the option earlier?
Could the current timing be correlated to UK Application?
Why expanded Loan NOW!
we have known that the interest rates are going up soon... why not exercise the option earlier?
Could the current timing be correlated to UK Application?
- Mon Feb 28, 2022 2:30 pm
- Forum: ImetelChat
- Topic: CTC and Imet
- Replies: 1
- Views: 918
CTC and Imet
Question for folks on the science and medical side. Would Imetelstat help with the circulating tumor cells? Someone very close was recently Dx with late stage terminal bladder cancer which has metastasized to bone and lungs. Rightfully, the Oncologist is leaning on Pembro immunotherapy. I would like...
- Sat Dec 11, 2021 12:01 am
- Forum: ImetelChat
- Topic: Fellow Board Members
- Replies: 9
- Views: 2529
Re: Fellow Board Members
Andrew, Wasn't this study one which proceeded after discussions with the FDA? If so, then the new additional analysis, in the middle of the P3 trial proceeding seems unusual. However, if there is "new" player who wants additional data - which prior FDA discussions did not particularly pre-specify......
- Fri Dec 10, 2021 5:39 pm
- Forum: ImetelChat
- Topic: Fellow Board Members
- Replies: 9
- Views: 2529
Re: Fellow Board Members
Andrew, Excellent news and information. Thank you. I will repost a hypothesis postulated a few weeks ago. =========== Andrew Thank you as always for wonderful analysis. Quick question or rather feedback on an hypothesis. Any possibility that ventricular repolarization is mandated for ILAP? Drug Cand...
- Fri Nov 26, 2021 5:50 am
- Forum: ImetelChat
- Topic: Sherlock Holmes and the QT interval
- Replies: 22
- Views: 6803
Re: Sherlock Holmes and the QT interval
Any stats expert on the forum?
Would be very interesting to postulate the P value of the additional cohort if/ when/as data is unblinded - and assuming the Phase 2 efficacy is replicated.
Would be very interesting to postulate the P value of the additional cohort if/ when/as data is unblinded - and assuming the Phase 2 efficacy is replicated.
- Thu Nov 25, 2021 5:09 pm
- Forum: ImetelChat
- Topic: Sherlock Holmes and the QT interval
- Replies: 22
- Views: 6803
Re: Sherlock Holmes and the QT interval
Andrew Thank you as always for wonderful analysis. Quick question or rather feedback on an hypothesis. Any possibility that ventricular repolarization is mandated for ILAP? Drug Candidate effectiveness can be acceptable when considering - RWD and phase 2 days. P3 days cannot be unblinded early for o...
- Mon Oct 11, 2021 10:59 pm
- Forum: ImetelChat
- Topic: Real World Data Lives! So to speak…
- Replies: 4
- Views: 1611
Re: Real World Data Lives! So to speak…
I genuinely hope... this is the trigger for sustained momentum of news being shared with the marketplace on the drug candidate's effectiveness!
It's SHOWTIME...
It's SHOWTIME...