Search found 1734 matches

by biopearl123
Mon Jun 24, 2024 5:20 am
Forum: ImetelChat
Topic: Where we are at
Replies: 3
Views: 192

Re: Where we are at

RC, nicely done! You should get bored more often. A couple of points. First calling for a review of the MF study. Don't forget there is a DSMB that reviews active studies on an ongoing basis usually quarterly. They have the power to recommend stopping the study, be it for futility (not an issue so f...
by biopearl123
Sun Jun 23, 2024 12:16 am
Forum: ImetelChat
Topic: Geron website says looking for partners
Replies: 6
Views: 996

Re: Geron website says looking for partners

Yup, old news
by biopearl123
Fri Jun 21, 2024 2:55 am
Forum: ImetelChat
Topic: New video
Replies: 4
Views: 1167

Re: New video

RC, thanks for posting this. I am sure you caught the part about the new 2022 classification that took some patients into a higher risk category that still showed important drug effect. Bodes well for the HR/AML study.
by biopearl123
Thu Jun 20, 2024 3:58 am
Forum: ImetelChat
Topic: Stealth Study Update
Replies: 8
Views: 1858

Re: Stealth Study Update

Yes, the nice Australian lady clearly the poster child (well, elder states person) brought out to highlight a study that is probably going well. She was clearly in the pink and quite grateful for her care and pleased with the results. We are never privy to the actual protocol details but a midway ev...
by biopearl123
Tue Jun 18, 2024 11:10 pm
Forum: ImetelChat
Topic: Stealth Study Update
Replies: 8
Views: 1858

Stealth Study Update

The single agent AML study certainly took the spotlight on this board when the study stopped enrolling at the 23 patient mark. (The back drop here being a lot out of QIMR to support a positive view of this event. If the study were stopped for bad data that would have been material, but nada so far.)...
by biopearl123
Tue Jun 18, 2024 4:56 am
Forum: ImetelChat
Topic: Gilead hunting?
Replies: 1
Views: 643

Re: Gilead hunting?

Jay, that was a 4 Billion (with a B) mistake. Perhaps if they’d waited 1. for a more mature data set with excellent PIII data, 2. a “derisked” drug 3. one with resounding FDA approval. 4. One with multiple other promising indications in liquid tumors. 5. One that is an entirely new class of drug. 6....
by biopearl123
Mon Jun 17, 2024 7:33 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

LWS, I think you are familiar with the MF data but if you wish you can review some of it here:

https://s201.q4cdn.com/710325604/files/ ... _FINAL.pdf
by biopearl123
Sun Jun 16, 2024 8:30 pm
Forum: ImetelChat
Topic: Principal Investigator Dr. Aleksandra M Stevens, MD, Phd
Replies: 4
Views: 1181

Re: Principal Investigator Dr. Aleksandra M Stevens, MD, Phd

Kmall and HI, as you point out a potentially exciting study. Dont know if this is overly optimistic but follow up time time is five years!!
by biopearl123
Sun Jun 16, 2024 5:34 am
Forum: ImetelChat
Topic: Principal Investigator Dr. Aleksandra M Stevens, MD, Phd
Replies: 4
Views: 1181

Re: Principal Investigator Dr. Aleksandra M Stevens, MD, Phd

HI, not sure about that but it would be great if true. The peds study has been “on the books” since Feb of this year with an anticipated start date of mid July, that has not changed. However as you suggest the Telomere trial may have gotten the green light to go ahead on the basis of the single agen...
by biopearl123
Sun Jun 16, 2024 1:12 am
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

LWS, you may be conflating data from the MF and MDS trials. The data presented at EHA was strictly from the MDS trial.
by biopearl123
Sat Jun 15, 2024 7:34 pm
Forum: ImetelChat
Topic: EHA
Replies: 13
Views: 2209

Re: EHA

LWS, where is there information to support your post that OS is longer? I have seen data to suggest no adverse effect on OS but not prolongation. Please clarify or edit your post.
by biopearl123
Sat Jun 15, 2024 1:45 am
Forum: ImetelChat
Topic: Ode to a Duck
Replies: 6
Views: 1360

Re: Ode to a Duck

Since its not a company sponsored trial I am not sure if the primary investigator is required to provide information as to a status change within a specific timeline.
by biopearl123
Fri Jun 14, 2024 9:04 pm
Forum: ImetelChat
Topic: from abstract of EHA presentation today!
Replies: 3
Views: 834

Re: from abstract of EHA presentation today!

Jay, do you see anything new in here? Seems consistent with the previously released abstract about a month ago.
by biopearl123
Fri Jun 14, 2024 4:56 am
Forum: ImetelChat
Topic: Ode to a Duck
Replies: 6
Views: 1360

Ode to a Duck

Looks like a duck: preclinical lab data showing “cure” in AML rat model, Dr. Lane sits with Dr. S at a major heme meeting several years ago to discuss Quacks like a duck: Drs. Bruedigam/Lane have an important paper published that makes a major contribution to the understanding of ferroptosis (Future...
by biopearl123
Thu Jun 13, 2024 5:27 am
Forum: ImetelChat
Topic: this study is starting 7/12/2024
Replies: 8
Views: 1504

Re: this study is starting 7/12/2024

Late breaking abstracts open Oct 16th. It does seem that ASH should be the forum for the AML data.
by biopearl123
Thu Jun 13, 2024 2:48 am
Forum: ImetelChat
Topic: this study is starting 7/12/2024
Replies: 8
Views: 1504

Re: this study is starting 7/12/2024

Don’t see a mechanism for that to happen. Abstracts already published
by biopearl123
Wed Jun 12, 2024 7:48 pm
Forum: ImetelChat
Topic: AML/HR MDS change in study status, ?good news?
Replies: 7
Views: 1229

AML/HR MDS change in study status, ?good news?

As of today the study status of the AML single agent study (a collaboration of investigator sponsors from Australia, Germany and France) has moved to “Active, not recruiting…). As you recall the top line data date was extended by a year on the heels of some amazing PR from Dr. Lane’s lab in Australi...
by biopearl123
Wed Jun 12, 2024 2:41 pm
Forum: ImetelChat
Topic: YMB Your comment has been rejected.
Replies: 9
Views: 1343

Re: YMB Your comment has been rejected.

Well said , HI. Great summary.
by biopearl123
Wed Jun 12, 2024 1:05 am
Forum: ImetelChat
Topic: PPS
Replies: 111
Views: 160249

Re: PPS

Wow, just mention MAIA and the genie appears:

https://workforcenow.adp.com/mascsr/def ... bId=504260
by biopearl123
Wed Jun 12, 2024 1:03 am
Forum: ImetelChat
Topic: YMB Your comment has been rejected.
Replies: 9
Views: 1343

Re: YMB Your comment has been rejected.

Thanks KT, I can assure you it was both conscious and intentional.