Search found 1688 matches

by biopearl123
Thu May 23, 2024 6:52 pm
Forum: ImetelChat
Topic: Launch
Replies: 7
Views: 606

Re: Launch

Lacour, you can be sure Geron in locked and loaded for market release. There will be serious PR at the time of approval. Just as we saw the remarkable preparation for the ODAC meeting, so too will we see the fruit of the as yet behind the scenes preparation that has been taking place. I think there ...
by biopearl123
Thu May 23, 2024 7:31 am
Forum: ImetelChat
Topic: NSCLC / Imetelstat
Replies: 1
Views: 381

Re: NSCLC / Imetelstat

Lekola, my recollection is that these studies entered the clinic in the mid 2000’s and basically were either stopped for futility or not advanced further because it took too many cell divisions to have a meaningful clinical effect. Jerry Shay is now an advisor to MAIA.
by biopearl123
Wed May 22, 2024 11:13 pm
Forum: ImetelChat
Topic: Basis for Approval....
Replies: 7
Views: 887

Re: Basis for Approval....

Hunt and Lacour, (and others), implicit in your comments in the indelible memory of the serious twisting of the shorts (sartorial shorts that is) that occurred in 2018. The memory of the scramble to get emergency loans not to mention emergency therapy feels like yesterday so I can’t blame you for wa...
by biopearl123
Wed May 22, 2024 7:53 am
Forum: ImetelChat
Topic: Basis for Approval....
Replies: 7
Views: 887

Re: Basis for Approval....

Great summary HI, thank you.
by biopearl123
Mon May 20, 2024 8:06 pm
Forum: ImetelChat
Topic: Disease Modification and OS
Replies: 3
Views: 936

Disease Modification and OS

Disease modification is defined by Wikipedia as : disease-modifying treatment, disease-modifying drug, or disease-modifying therapy is a treatment that delays, slows or reverses the progression of a disease by targeting its underlying cause. [11 They are distinguished from symptomatic treatments tha...
by biopearl123
Sun May 19, 2024 3:05 am
Forum: ImetelChat
Topic: The thing about OS
Replies: 2
Views: 886

The thing about OS

Patients with LR MDS die from a multitude of causes including progression to HR/AML, infection, development of cardiovascular disease and iron overload complications ("One unit of transfused blood contains about 200-250 mg of iron. In general, patients who receive more than 10 to 20 units of blood a...
by biopearl123
Sat May 18, 2024 3:16 am
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 8
Views: 2663

Re: EHA Abstracts

HI, you are most certainly correct. No PR? To be sure Geron is maintaining radio silence and avoiding anything that might piss off the almighty FDA including updates on P I or P II studies. Once there is an approved drug on the market, maybe they will grow a pair, till then mums the word. Interestin...
by biopearl123
Thu May 16, 2024 11:09 pm
Forum: ImetelChat
Topic: Interesting timeline (as we wait)
Replies: 1
Views: 865

Interesting timeline (as we wait)

Luspatercept was granted a plenary in 2018: "Dr. List discusses results from the MEDALIST trial in patients with transfusion-dependent myelodysplastic syndromes, which were presented as a plenary abstract at the 2018 ASH Annual Meeting." Luspatercept was granted FDA approval for MDS in August 2023. ...
by biopearl123
Wed May 15, 2024 2:21 am
Forum: ImetelChat
Topic: Are the abstracts posted?
Replies: 5
Views: 1205

Re: Are the abstracts posted?

Pretty nice abstract rating an oral presentation with updated data continuing to confirm dramatic rises in Hgb in responders and long durations of TI. I don’t think there is anything that will touch that. Interesting about the OS and the conclusion that at about two years the OS is similar in both g...
by biopearl123
Tue May 14, 2024 4:19 pm
Forum: ImetelChat
Topic: Are the abstracts posted?
Replies: 5
Views: 1205

Are the abstracts posted?

If you find them please post a link
by biopearl123
Sat May 11, 2024 11:12 pm
Forum: ImetelChat
Topic: FDA v. Geron
Replies: 45
Views: 13305

Re: FDA v. Geron

You have the option to read the posts you find interesting/relevant and not to read the ones you don’t.
by biopearl123
Sat May 11, 2024 5:56 am
Forum: ImetelChat
Topic: My shareholder questions (with answers)
Replies: 7
Views: 1187

Re: My shareholder questions (with answers)

Ok gents, this is drifting into the ad hominem. Don’t make me get out the red pencil.
by biopearl123
Fri May 10, 2024 10:39 am
Forum: ImetelChat
Topic: In transit
Replies: 0
Views: 464

In transit

I am in transit after an extensive visit to the Gaza/Israel boarder to evaluate the Magen David Adom (Israeli equivalent of the Red Cross). I would love to share my thoughts and experiences there but I can not without violating the basic guidelines we have for the most part kept to on this board. I ...
by biopearl123
Thu May 09, 2024 8:35 am
Forum: ImetelChat
Topic: Questions for Shareholders meeting
Replies: 1
Views: 466

Questions for Shareholders meeting

Submitted on the fly from Tel Aviv: 1. In patients with long term TIs can we start thinking about potential cure or is there still evidence for minimal residual disease? 2. Does the DMB have the power to recommend early discontinuation of the either MF study for efficacy? 3. Have any abstracts been ...
by biopearl123
Fri May 03, 2024 5:49 am
Forum: ImetelChat
Topic: Extension of MF study timeline, a few thoughts
Replies: 2
Views: 809

Extension of MF study timeline, a few thoughts

I have not had time to listen directly to the quarterly report today but gleaned that there was an extension of the timeline for “first look” data into 2026 due to patients living longer. The DSMB reviewed data and allowed the study to continue. As we know this means no futility signal and no undue ...
by biopearl123
Fri May 03, 2024 5:21 am
Forum: ImetelChat
Topic: Hi Everyone
Replies: 5
Views: 1431

Re: Hi Everyone

Thanks Fellow Board members and those who have communicated privately with me. Heading out early tomorrow. Back in about ten days. A few quick thoughts to be posted on the next thread.
by biopearl123
Mon Apr 29, 2024 8:01 pm
Forum: ImetelChat
Topic: Hi Everyone
Replies: 5
Views: 1431

Hi Everyone

Just a pat on the back and a thank you to all who have supported this board over the years. I suppose it’s not too optimistic to reopen the discussion of Turtle Island. For me, well, just too old now. Will have to sock away those gains for long term care :). For some however I truly hope you get the...
by biopearl123
Fri Apr 19, 2024 5:43 pm
Forum: ImetelChat
Topic: Ryan, you are always teaching me new words
Replies: 1
Views: 591

Ryan, you are always teaching me new words

I like this one: “ Imminenter”. Probably should submit to Merriam-Webster for new word of the year.
by biopearl123
Fri Apr 12, 2024 1:06 am
Forum: ImetelChat
Topic: Why is this man smiling? Or, the thing about good studies
Replies: 3
Views: 1205

Why is this man smiling? Or, the thing about good studies

Why is JS smiling that confident smile? It’s not because FDA approval for LR MDS is pending. He smiled that smile a long time ago but maybe some people just didn’t notice. Nope. He is smiling because he knows two prominent things (among the many). #1. The AML study was extended by a year a while bac...