Search found 2069 matches

by biopearl123
Tue Mar 18, 2025 1:51 am
Forum: ImetelChat
Topic: Survival studies in MF revisited
Replies: 3
Views: 671

Re: Survival studies in MF revisited

Lacour, enrollment to 100% is not required nor likely. It probably has nothing to do with Dr. Scarlett but rather a desire to have a watertight presentation of data for the FDA. They will follow the protocol to the letter unless the Data Safety Monitoring Board stops the study for efficiency. (They ...
by biopearl123
Mon Mar 17, 2025 8:11 pm
Forum: ImetelChat
Topic: Survival studies in MF revisited
Replies: 3
Views: 671

Survival studies in MF revisited

It looks like about 35% of BAT (non Imetelstat) R/R MF patients are dead between 6 and 10 months in these studies. Recall that the current study has a rolling enrollment, that is they don’t all leave the starting gate at the same time but each patient leaves the gate when there is “intention to trea...
by biopearl123
Mon Mar 17, 2025 3:29 pm
Forum: ImetelChat
Topic: An example of a reasonable discussion that got highjacked by the amygdala
Replies: 1
Views: 491

An example of a reasonable discussion that got highjacked by the amygdala

We have seen many examples of the FDA doing good work. But like other organizations that impact medical research it is not above self examination. I think an overt example of this has affected us all and is not a “left/right” issue so please don’t go zero to 60 in one second over this. I submit for ...
by biopearl123
Sat Mar 15, 2025 4:26 am
Forum: ImetelChat
Topic: New FDA objectives......who could be against this?
Replies: 7
Views: 1743

Re: New FDA objectives......who could be against this?

Shut it down guys, please. There is no question that the FDA is being guided toward a change in focus. Left or right is immaterial to this discussion.
by biopearl123
Sat Mar 15, 2025 3:33 am
Forum: ImetelChat
Topic: Letter from Errol
Replies: 2
Views: 884

Re: Letter from Errol

Errol’s response, Hi, XXXX. Thank you so much for posting my letter on I-chat. I really appreciated your letter to Dawn! I think they will address all of your questions and concerns in a timely manner. New leadership always feels pressure not to repeat failures of the former. Great big thank you! Er...
by biopearl123
Fri Mar 14, 2025 8:59 pm
Forum: ImetelChat
Topic: New FDA objectives......who could be against this?
Replies: 7
Views: 1743

Re: New FDA objectives......who could be against this?

I will take it one step further (without getting political). I was once doing volunteer medical work in a third world country. At dinner I noted that the vegetables were perfect and tasted great. I asked my hosts how they accomplished this. The answer was, “that’s simple, we use DDT.” There certainl...
by biopearl123
Fri Mar 14, 2025 8:16 pm
Forum: ImetelChat
Topic: The unbearable lightness of being
Replies: 1
Views: 541

The unbearable lightness of being

Clinical trials site for the ongoing MF trial has been updated to show complete pushed out by about another 18 months (June 2028). It appears that if you drink from the Holy Grail, you live a long time.
by biopearl123
Fri Mar 14, 2025 5:50 pm
Forum: ImetelChat
Topic: New FDA objectives......who could be against this?
Replies: 7
Views: 1743

Re: New FDA objectives......who could be against this?

Hi guys we can definitely have this discussion without making it “political “. I submit for your consideration: trans fatty acids , remember them and carminic acid derived from red ants (eg red dye).
by biopearl123
Fri Mar 14, 2025 2:00 am
Forum: ImetelChat
Topic: This is a start, please add. Let’s get ready for May
Replies: 1
Views: 860

This is a start, please add. Let’s get ready for May

Dear Dawn, as you can see many posters and stockholders in general need some reassurance. I would encourage you to consider a special letter to stockholders to address how you view the changes in Geron’s leadership and your vision for the future. It has been a long road to reach this point. Transpar...
by biopearl123
Fri Mar 14, 2025 1:24 am
Forum: ImetelChat
Topic: Letter from Errol
Replies: 2
Views: 884

Re: Letter from Errol

Errol, To be sure your letter will be read by Geron management. I think you can take some comfort in Geron’s approach to physicians as gleaned from the various new positions they have established. I believe your recommendations are already being addressed and I would encourage you to see if Dr. XXXX...
by biopearl123
Fri Mar 14, 2025 1:19 am
Forum: ImetelChat
Topic: Letter from Errol
Replies: 2
Views: 884

Letter from Errol

One of my correspondents, Errol is undergoing treatment for his hematologic disorder. He has given me permission to share one of his recent letters to me: Hi XXXX I'm not a member of I-chat and not an eloquent writer. I want to share some ideas that you can post at I-chat if you see fit. I believe t...
by biopearl123
Thu Mar 13, 2025 12:40 pm
Forum: ImetelChat
Topic: "DAWN OF A NEW ERA!"
Replies: 5
Views: 1291

Re: "DAWN OF A NEW ERA!"

Stanley rock nice letter! Am on the road to Kansas City and will post something from “Errol” once I get settled.
by biopearl123
Wed Mar 12, 2025 12:42 am
Forum: ImetelChat
Topic: Kudos to Dr. Scarlett
Replies: 6
Views: 1349

Re: Kudos to Dr. Scarlett

Kmall, while it ain’t “X”, a lot of folks do read this board (well, maybe not Elon, wouldn’t it be great if he did?) I would not underestimate the weight of your words, both recent and past. There are not too many places for the BOD to take the pulse of those interested in Geron (I do not advise YMB...
by biopearl123
Tue Mar 11, 2025 10:57 pm
Forum: ImetelChat
Topic: Kudos to Dr. Scarlett
Replies: 6
Views: 1349

Kudos to Dr. Scarlett

John from me, thank you. For those who don’t remember the twists and turns successful navigated by John and his board, let me refresh. The company was trashed by his predecessor, Tom Okarma. John was wise enough to jettison the stem cell business which continues to flail under different management. ...
by biopearl123
Tue Mar 11, 2025 10:33 pm
Forum: ImetelChat
Topic: Calling BOD to act
Replies: 8
Views: 2836

Re: Calling BOD to act

Looks like the board heard your voices.
by biopearl123
Tue Mar 11, 2025 8:07 pm
Forum: ImetelChat
Topic: FWIW--EMA
Replies: 6
Views: 1265

Re: FWIW--EMA

You'd better buy some crutches, just in case.
by biopearl123
Tue Mar 11, 2025 3:24 pm
Forum: ImetelChat
Topic: Calling BOD to act
Replies: 8
Views: 2836

Re: Calling BOD to act

Stanleyrock, The stockholders meeting is coming up in May. This is virtually the only time you can make your (and our) voice heard. There is obviously something in the works, good or bad, hopefully good. EU approval is pending but how much that will help the bottom line is questionable and we should...