Search found 299 matches

by biopearl123
Sun May 31, 2020 1:41 am
Forum: ImetelChat
Topic: to Kmall the fine print
Replies: 0
Views: 2

to Kmall the fine print

Kmall, I think getting clarity on the point below would be great if you can frame some questions for Dr. S. First off slide 6 of the new presentation makes the following statement: *Data on file--take a look, I could not get it to copy but basically the data on file references the statement that hem...
by biopearl123
Sat May 30, 2020 6:56 pm
Forum: ImetelChat
Topic: Finally some statement about fibrosis reversal
Replies: 2
Views: 260

Re: Finally some statement about fibrosis reversal

Kmall, from what I have seen of you, you certainly do not need my guidance! Go for it. I look forward to the day when you tell us you are buying a bigger boat...bp
by biopearl123
Sat May 30, 2020 12:55 am
Forum: ImetelChat
Topic: embargo?
Replies: 1
Views: 235

embargo?

The MDS oral presentation says it it embargoed until the meeting, yet we have access to the abstract. So what is embargoed? I suspect it is the MDS bone marrow data. What if bone marrow is normalizing in the TI patients? We have seen suggestions in the past but this could be the research bombshell G...
by biopearl123
Sat May 30, 2020 12:46 am
Forum: ImetelChat
Topic: Finally some statement about fibrosis reversal
Replies: 2
Views: 260

Finally some statement about fibrosis reversal

This from one of the upcoming EHA abstracts: "Among 57 pts with available bone marrow data, 19 pts (33%) had ≥1 degree of bone marrow fibrosis improvement while on study and had a significant longer OS than those who had worsening bone marrow fibrosis (HR=0.36, 95% CI 0.13-0.96 p=0.04). A similar tr...
by biopearl123
Fri May 29, 2020 1:02 am
Forum: ImetelChat
Topic: Re new presentation
Replies: 2
Views: 555

Re new presentation

I think it’s clear from the new presentation that Geron has shown their cards. They are going for it all: the entire gamut of myeloproliferative diseases: MF MDS —Both low and high risk, AML, PV, ET. All of it. All. Sit back. bp
by biopearl123
Tue May 26, 2020 6:57 pm
Forum: ImetelChat
Topic: Questions for the upcoming shareholders meeting
Replies: 0
Views: 420

Questions for the upcoming shareholders meeting

With thanks to CKTC and HI and others for making the points that helped me frame this note: Dear Dr. Scarlett, I write to you in your capacity as President, CEO and Chairman of the Board with the following questions submitted for your consideration at the yearly shareholders meeting, June 5th, 2020....
by biopearl123
Thu May 21, 2020 3:12 am
Forum: ImetelChat
Topic: A few thoughts
Replies: 3
Views: 634

A few thoughts

First off Kmall, great posts, thank you. You hit it out of the park. And to rocky and cathy, thank you for your kind words posted elsewhere. I invite you to post here but in truth this board has been paralyzed by now over 20,000 bogus requests to register. They come from strange domains like .xyz or...
by biopearl123
Fri May 15, 2020 8:03 pm
Forum: ImetelChat
Topic: What you don't see...
Replies: 1
Views: 901

What you don't see...

What we don't see is in looking over the general categories of competition for Imetelstat in both MF isn MDS is: wait for it-- not much. In MF there is Rux but presentations at EHA seem to lean toward Rux withdrawal syndrome or the increased incidence of secondary malignancies. Yes there is interfer...
by biopearl123
Fri May 15, 2020 12:39 am
Forum: ImetelChat
Topic: EHA Abstracts
Replies: 2
Views: 1065

Re: EHA Abstracts

Muskateer, Unfortunately I am not the person you are looking for but I do have a few observations to share. In MDS first off, a prestigious oral presentation confirming the durability of TI. Its major, looks to me like there is nothing close. Since we only see the abstract, I suspect we will be trea...
by biopearl123
Tue May 05, 2020 10:39 pm
Forum: ImetelChat
Topic: A reminder that TI was also achieved in Mayo study
Replies: 0
Views: 710

A reminder that TI was also achieved in Mayo study

Anyone remember where this came from? "Four of the 13 patients (31%) who had been dependent on red-cell transfusions became transfusion-independent for at least 3 months." That's right, its from the Tefferi NEJM 2015 MF article. The one where there were CRs and PRs that was stopped before ORR could ...
by biopearl123
Tue May 05, 2020 10:35 pm
Forum: ImetelChat
Topic: My response to Cheng Ho on SA board
Replies: 0
Views: 579

My response to Cheng Ho on SA board

Bill really, first off, as to Dr. T's Italy comments, I heard them too. It was about maybe 4 years ago and in the wake of the great Geron/Dr. T/FDA rupture. I wondered after the NEJM article how it must feel to Dr. T to be the first clinician in the world to demonstrate complete remission and bone m...
by biopearl123
Mon May 04, 2020 12:17 am
Forum: ImetelChat
Topic: Excellent post from kmall YMB
Replies: 1
Views: 695

Re: Excellent post from kmall YMB

Suspect the FDA meeting to discuss potential approval/future study design for MF will come once the EHA abstracts are public (May 14). Shortly after that Geron should make the results of that meeting public, I suspect before the annual shareholders meeting. Then finalization re future development fo...
by biopearl123
Mon May 04, 2020 12:08 am
Forum: ImetelChat
Topic: Excellent post from kmall YMB
Replies: 1
Views: 695

Excellent post from kmall YMB

From kmall YMB: @Jerry Reading through a company's proxy one must consider "legalities"......this has been obviously scrutinized over by Gerons team of lawyers - which there are about a half dozen or so. From what I was able to skim through and what Hunter has aptly pointed out, I for one feel quite...
by biopearl123
Fri May 01, 2020 5:36 pm
Forum: ImetelChat
Topic: Geron Corporation has added a new financial report to its website:
Replies: 1
Views: 653

Re: Geron Corporation has added a new financial report to its website:

Hat tip to hunt YMB for doing the Digging “ . If approved for marketing by regulatory authorities, we plan to commercialize imetelstat in the United States and seek potential commercialization partners for territories outside of the United States. We hold issued patents covering imetelstat compositi...
by biopearl123
Sun Apr 26, 2020 11:29 pm
Forum: ImetelChat
Topic: Near term events
Replies: 3
Views: 1078

Re: Near term events

Me too, brother. As the Ram Bam said, if not now, when?
by biopearl123
Sun Apr 26, 2020 6:45 pm
Forum: ImetelChat
Topic: Enhancement of Myeloproliferative Stem Cells
Replies: 1
Views: 470

Re: Enhancement of Myeloproliferative Stem Cells

GREAT post earfool, thank you. This may explain the findings presented in the Hu poster at last year's ASH. bp
by biopearl123
Sun Apr 26, 2020 2:23 am
Forum: ImetelChat
Topic: New paper of interest
Replies: 1
Views: 544

Re: New paper of interest

by biopearl123
Sun Apr 26, 2020 12:29 am
Forum: ImetelChat
Topic: New paper of interest
Replies: 1
Views: 544

New paper of interest

https://www.sciencedirect.com/science/a ... 1X20307798

May turn up at EHA. No doubt Incyte taking careful note. Regards, bp