Recent review article

[biopearl123]

Hat tip to Richard on YMB for providing this reference: http://www.bloodadvances.org/content/2/ ... ecked=true

I will try to post the table which shows Imetelstat furtherest along in development compared with other new potential treatments. The article highlights the fact that no new drugs have been approved in the past ten years for MDS. Looking a mechanisms, its hard to get more "upstream" than treating the malignant clone and CSC itself. Several new agents in development are discussed including Imetelstat. bp

[biopearl123]

Attempted to copy Table 1. Not successful in a readable way. Note that Imetelstat entering Phase III but some therapies already listed as P III with most in earlier stages of development. Nonetheless in terms of targeting that malignant clone directly and upstream, it appears that Imetelstat has a unique MOA. Anyway the article is worth a read. Awaiting ASH with great interest. bp

[nerdyboy99]