New Patent / IMET 2.0 ?

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j6proulx
Posts: 23
Joined: Mon Jun 25, 2018 10:20 pm

New Patent / IMET 2.0 ?

Post by j6proulx » Mon Aug 13, 2018 7:44 pm

A new patent was issued to Geron on July 31, 2018, relating to compounds useful in inhibiting telomere elongation. See: https://tinyurl.com/y976ctrh (link to USPTO patent). I've yet to review and would welcome comments from others who do.

Best regards,
j6p

cheng_ho
Posts: 202
Joined: Sun Apr 03, 2016 11:27 pm

Re: New Patent / IMET 2.0 ?

Post by cheng_ho » Wed Aug 15, 2018 9:44 pm

This "new" patent was filed as a provisional by Sergei back in 2011.

You can read several papers on these modified G TIs on the Shay web site.

There is also this possibility for Imet 2.0:

https://www.ncbi.nlm.nih.gov/pubmed/26479411

...and everyone has known about these possibilities for years... except, apparently, JNJ ;)

biopearl123
Posts: 1665
Joined: Fri Jul 20, 2018 5:13 pm

Re: New Patent / IMET 2.0 ?

Post by biopearl123 » Fri Aug 17, 2018 1:48 am

J6, thank you for posting. This patent as Cheng points out was provisional but now as you have kindly posted appears to have been issued. Note the provision for oral administration. As yet we know nothing about potential synergism in vivo but it sure is interesting. Again thank you for your research and contributions. bp

j6proulx
Posts: 23
Joined: Mon Jun 25, 2018 10:20 pm

Re: New Patent / IMET 2.0 ?

Post by j6proulx » Fri Aug 17, 2018 6:15 pm

There was a second patent issued to Geron on July 31 that I overlooked:

http://patft.uspto.gov/netacgi/nph-Pars ... n&RS=geron

Synthesis of protected 3'-amino nucleoside monomers

Abstract

Orthogonally protected 3'-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3'-amino group in the presence of the unprotected nucleoside base.

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