Link to recent article on pancreatic cancer cell lines

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biopearl
Posts: 367
Joined: Wed Dec 09, 2015 12:12 am

Link to recent article on pancreatic cancer cell lines

Post by biopearl » Mon Mar 26, 2018 10:45 pm


Fishermangents
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Posts: 531
Joined: Thu Dec 03, 2015 3:39 pm

Re: Link to recent article on pancreatic cancer cell lines

Post by Fishermangents » Tue Mar 27, 2018 12:35 pm

Is on Imetelstat.info/pre-clinical

Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells

K.M. Burchett et al (2017)

Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. We have previously reported that GRN163L could shorten telomeres and limit the lifespan of CD18/HPAF and CAPAN1 pancreatic cancer cells. Here, we examined the effects of GRN163L on two other pancreatic cancer cell lines: AsPC1 and L3.6pl. In both lines, chronic exposure to GRN163L led to an initial shortening of telomeres followed by a stabilization of extremely short telomeres.

Results from this work suggest that inhibitors of telomerase and poly(ADP-ribose) polymerases can cooperate to limit the lifespan of pancreatic cancer cells.

(Published: Oncotarget, July 20, 2017)

Dogonenuts
Posts: 40
Joined: Tue May 10, 2016 6:13 pm

Re: Link to recent article on pancreatic cancer cell lines

Post by Dogonenuts » Wed Mar 28, 2018 5:46 pm

Some pretty heavy reading, but my if imet in combo with a parp could give pancreatic CA a good push back, now that would be huge. Pancreatic and glioblastoma are the final frontiers in oncology.

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