Link to recent article on pancreatic cancer cell lines
Posted: Mon Mar 26, 2018 10:45 pm
Repost from whyted/Sdraw: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663552/
Is on Imetelstat.info/pre-clinical
Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells
K.M. Burchett et al (2017)
Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. We have previously reported that GRN163L could shorten telomeres and limit the lifespan of CD18/HPAF and CAPAN1 pancreatic cancer cells. Here, we examined the effects of GRN163L on two other pancreatic cancer cell lines: AsPC1 and L3.6pl. In both lines, chronic exposure to GRN163L led to an initial shortening of telomeres followed by a stabilization of extremely short telomeres.
Results from this work suggest that inhibitors of telomerase and poly(ADP-ribose) polymerases can cooperate to limit the lifespan of pancreatic cancer cells.
(Published: Oncotarget, July 20, 2017)