Question to pose
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- Comments must be civil and on topic
- Back up claims with evidence/reasoning/sources (posting links is allowed)
- No commercials/harassment/spam
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- Posts: 40
- Joined: Tue May 10, 2016 6:13 pm
Question to pose
With the OS in the Imbark trial now up to 19-21 months, would a new treatment paradigm be worth considering? Would not combination therapy from the outset seem more reasonable, though expensive? Or, even imet from the start and splenectomy if a bonemarrow biopsy and aspirate show reversal of marrow fibrosis and thus return of normal hematpoesis. This would be cheaper than continuing Jakafi purely for symptomatic relief knowing that when the patients fail Jakfi they will be in worse shape.
Re: Question to pose
Dogonenuts, you are WAY ahead of yourself. There will be not combination therapy until there are studies to support this approach. There might not even be front line single therapy in MF without further study (some info available from Mayo) but unless physicians use the drug off label which they might, further study for both single drug and combination therapy will probably be required. bp
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- Posts: 40
- Joined: Tue May 10, 2016 6:13 pm
Re: Question to pose
Oh, I know there would have to be some studies. Just thinking where this thing might go over the next few years and why JnJ might jump whole hog for GERN.
Re: Question to pose
You are right about that. The Janssen "skunk works" lab studies have probably opened many doors which remain unknown to us. Judging by the last patent filing many many doors. bp