Telomerase-focused therapies hold the promise of eradicating cancer stem cells.

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Fishermangents
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Telomerase-focused therapies hold the promise of eradicating cancer stem cells.

Post by Fishermangents » Fri Jun 17, 2016 3:20 pm

From the report:

New surprises from an old favourite: The emergence of telomerase as a key player in the regulation of cancer stemness
K. Teralı, A. Yilmazer (2015)

Highlights
• Telomerase has the capacity to regulate numerous cancer-promoting genes and pathways.
• A mechanistic explanation for the regulatory role of telomerase in cancer stem cells is provided.
• Telomerase contributes to tumorigenesis via the acquisition and retention of cancer stemness.
• There is a positive feedback loop between a number of oncoproteins/oncogenic pathways and TERT.
• Telomerase-focused therapies hold the promise of eradicating cancer stem cells.

Abstract
It has been well established that the upregulation/reactivation of telomerase is a prerequisite for cellular immortalisation and malignant transformation. More significantly, perhaps, telomerase stands at the crossroads of multiple signalling pathways and its upregulation/reactivation leads to the modulation of critical cellular processes, including gene expression and metabolism. In recent years, this multifaceted ribonucleoprotein particle has become increasingly associated with the cancer stem cell (CSC) phenotype in various human cancers. Cancer stemness is a major contributor to therapy resistance and hence tumour recurrence. Here, we discuss new findings about the telomere-independent tumour-promoting functions of telomerase and provide a mechanistic explanation for its regulatory role in CSC biology. It is striking that there is a positive feedback loop between a number of gene products targeting telomerase's reverse transcriptase subunit (TERT) and TERT expression itself. This plausibly amplifies the effects of central oncogenes and oncogenic pathways related to cancer stemness in a cell-autonomous fashion. A more complete elucidation of these regulatory mechanisms affords the opportunity to develop telomerase-focused therapies that differentiate or kill CSCs effectively.

http://www.sciencedirect.com/science/ar ... 8415004113
http://www.ncbi.nlm.nih.gov/pubmed/26700144

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