Long telomeres

[biopearl123]

https://www.nytimes.com/2023/05/04/heal ... evity.html

Well how bout that. Well there’s a surprise , take that TA65.

[LWS]

Is this a 'Goldilocks' consideration? Telomeres should not be too long or too short, but just right.
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Telomeres, Telomerase, Immortal cells, cancer, long life are all connected in ways that we are only beginning to understand.

+Epub 2020 Sep 2.
Telomere length: how the length makes a difference
M Lulkiewicz 1, J Bajsert 1, P Kopczynski 2, W Barczak 3 4, B Rubis 5

Affiliations expand
PMID: 32876842 PMCID: PMC7561533 DOI: 10.1007/s11033-020-05551-y
Free PMC article

Abstract

Telomerase is perceived as an immortality enzyme that might provide longevity to cells and whole organisms. Importantly, it is generally inactive in most somatic cells of healthy, adult men. Consequently, its substrates, i.e. telomeres, get shorter in most human cells with time. Noteworthy, cell life limitation due to telomere attrition during cell divisions, may not be as bad as it looks since longer cell life means longer exposition to harmful factors. Consequently, telomere length (attrition rate) becomes a factor that is responsible for inducing the signaling that leads to the elimination of cells that lived long enough to acquire severe damage. It seems that telomere length that depends on many different factors (including telomerase activity but also genetic factors, a hormonal profile that reflects sex, etc.) might become a useful marker of aging and exposition to stress. Thus in the current paper, we review the factors that affect telomere length in human cells focusing on sex that all together with different environmental and hormonal regulations as well as parental aspect affect telomere attrition rate. We also raise some limitations in the assessment of telomere length that hinders a trustworthy meta-analysis that might lead to acknowledgment of the real value of this parameter.

Keywords: Aging; Hormones; Immortality; Sex; Telomerase; Telomeres.

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Link Between Long Telomeres and Long Life Is a Tall Tale, Study Finds
The longer a person’s telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality.
www.nytimes.com

--- Science
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bp --- This appears to be a very interesting article. However, I cannot open it. Could you please summarize?---Thank, you

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What is TA 65?

Telomerase activator-65 (TA-65) is a telomerase small-molecule activator purified from the root of Chinese herbs that has been anecdotally reported to have anti-aging and life-extending potential.

[LWS]

Telomeres, Telomerase, Immortal cells, cancer, long life are all connected in ways that we are only beginning to understand.

Some thoughts (for future research): It is beginning to look like that there is an important relation between too much telomere (cancer), and not enough (cell death). Is there some place in the 'middle' that prolongs life, without causing cancer?
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Length

This enzyme, telomerase, is responsible for maintaining the length of telomeres. Without telomerase, telomeres progressively shorten until they die or cease functioning. However, by activating telomerase, it is possible to actively restore telomeres and allow for many future cell divisions.

[mistergern]

I think the timing of the Times article may be propitious. As a layman, it seems to support Scarlett's statement that Imetelstat alters the disease progression for MDS and probably MF. I think it will be an easier proposition to sell going forward and lays the foundation for Imetelstat to become a standard of care for hematological malignancies.

[Gwikley]

It's all in the book: The Telomere Effect.
Written by the Nobel winning team of Elizabeth Blackburn PhD and Elisa Epel PhD