Verstovsek: imetelstat 1 of the 2 hottest new drugs for MF

Forum rules
- Comments must be civil and on topic
- Back up claims with evidence/reasoning/sources (posting links is allowed)
- No commercials/harassment/spam
Post Reply
Fishermangents
Site Admin
Posts: 531
Joined: Thu Dec 03, 2015 3:39 pm

Verstovsek: imetelstat 1 of the 2 hottest new drugs for MF

Post by Fishermangents » Thu Apr 14, 2016 12:15 pm

In this video Dr. Srdan Verstovsek presents about MF and how current therapies fail to cure or to extend life expectancy significantly. From all the new drug developments (such as ACE011, JAK1 inhibitors, LOXL2, Hedgehog inhibitors, PRM151, LCL161, Bcl-xl inhibitors, IL3R, PD1 inhibitors) he mentiones imetelstat as the hottest, together with PRM151.

The difference between PRM151 and imetelstat is that PRM151 is targeted to reduce the production of fibrosis through a special enzyme, that the human body already produces to prevent the excess formation of fibrosis. So as it looks now, in a certain sense PRM151 targets a symptom (the formation of fibrosis) caused by the underlying disease (malignant stemcell clones). Imetelstat on the other hand directly targets the underlying disease, because it targets the malignant clone (see the slide about this patient, about who Dr. Scarlet elaborated so extensively ad the Needham conference to explain why imetelstat is disease modifying).

On min. 20:20 Dr. Verstovsek says: "The two hottest drugs right now, that almost every patient that visits us asks about, are imetelstat and PRM151." It is significant that a doctor of his caliber speaks so positive and extensive about imetelstat.

link to the video: https://www.youtube.com/watch?v=el7Fw7CYmiw

Post Reply