From AACR meeting earlier in April/June

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biopearl123
Posts: 1665
Joined: Fri Jul 20, 2018 5:13 pm

Re: From AACR meeting earlier in April/June

Post by biopearl123 » Thu Aug 20, 2020 3:23 am

Well, its great to see early research in other areas. Be great if there were a clinical application in CML BC which basically heralds the end. I am perplexed by the 30mg/kg, 3x/wk dosing which is basically many fold higher than the 9.4 mg/kg q 3 weeks we are seeing used in MF. Am I looking at this right? If true clearly toxicity in human patients would be an issue but maybe the outlook in BC is so dismal, there could be some applicability. bp

biopearl123
Posts: 1665
Joined: Fri Jul 20, 2018 5:13 pm

Re: From AACR meeting earlier in April/June

Post by biopearl123 » Tue Aug 25, 2020 5:15 pm

Looks like the doses in mice have been validated in the early Geron literature:

Utilization of Preclinical Xenograft Data in Predicting Human Imetelstat Target Tissue Concentrations

biopearl123
Posts: 1665
Joined: Fri Jul 20, 2018 5:13 pm

Re: From AACR meeting earlier in April/June

Post by biopearl123 » Tue Aug 25, 2020 5:28 pm


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