ImetelChat

Part III: Blood supply / requirements / transfusions: Blood supply and requirements in the US: https://www.redcrossblood.org/donate-blood/how-to-donate/how-blood-donations-help/blood-needs-blood-supply.html The Red Cross provides about 40% of our nation’s blood and blood components, all from genero...

Part II: Some basic blood information: I found this part as a refresher yet interesting. If you took all the blood vessels out of an average child and laid them out in one line, the line would stretch over 60,000 miles. An adult's would be closer to 100,000 miles long. There are three kinds of bloo...

Well here we are, in the so-called data desert and discussing hematology basics is one way to pass the time. Like many here, I’ve had to do a lot of reading and rereading to understand some of the basics in the Imetelstat space. Hopefully what follows can be of help to those just starting to learn a...

FWIW, I may not be seeing all Geron's efforts but it does not appear to me that Geron is as aggressively promoting Imetelstat or related CTs via social media as I thought they would. I expected much wider/deeper efforts especially with the pandemic enrollment issues, etc. Given I’m not particularly ...

Thanks again biopearl123, for taking this deeper and wider as usual! I continue to believe the reason we don’t have a partner, etc. as Dr. John Scarlett has said, the terms are not reflective of Geron/Imetelstat’s value and I suspect the starting point of the stock price will need to be considerably...

Bottomline for Constellation and Curis, even MAIA, and any others trying to enter this space, they much later to the game than Geron? I wonder are they just looking for additional “targets and hits” per ashah’s link or really trying to go head-to-head with Imetelstat. Disease modification (DM) is a ...

There is no problem if donations exceed the goal of $1000. euros. So far only 18 donations have been made so if one values this site and would like to push above the goal, IMO that would be great. With $1000 euros goal achieved, we can all breathe a sigh of relief, however that goal will only cover ...

Thank you Fish Jr.! Very thoughtful response and perfectly on target in my view. Also, a big thank you as well to biopearl123 for his many contributions and to ashah for the generous offer to step up to moderate the ImetelChat community going forward!

Dear Fish Jr. I am a member on ImetelChat and FWIW, I wanted to share my take on ImetelChat with you. In my opinion, if at all possible the site should be kept up and running for the next few years. I also realize it is a long shot for this to happen given both you and biopearl123 are wanting to ste...

First, a huge thank you to Fishermangents Sr./Jr. and you for all your time, effort and continuous contributions. I personally can say that this board is the only place I care to post on and find the information and analysis provided here to be of significant value to me but quite likely expect to o...

Ha! So granted my hunting analogy was crude at best, but I think both hunting and aiming in the right location is usually far more advantageous than speed to indiscriminate senescence or generalized coverage possibly excessively exacerbating cytopenias. Which I don’t believe was or could be fairly a...

I personally am not opposed to a partnership, however on the boards, we tend to generalize the partnership agreement which leaves so much to ones imagination or not. As we know, not all partnerships workout but they can have advantages and/or disadvantages. As JS/BOD/Geron gains traction in the regu...

Thanks again biopearl for posting these insightful links. This research paper, published in November 2018 and to date has not been updated. One has to wonder if JNJ incorrectly interpreted this information prior to the negative CD. Certainly an interesting paper, however, IMHO the goal seems to be r...

Thanks for sharing. Excellent and very interesting work again by Dr. Ayalew Terreri. Seems like it’s been a while since he’s shown up on our radar like this and clearly provided a significant level of support for Imetelstat. While I appreciate the contribution, It’s a stretch to say Geron blew anyth...

Part 2: Over the next couple years Geron will complete building the vertical organization and infrastructure to deliver Imetelstat to patients with hematologic cancers and eventually to patients with other malignancies. Will any BP do it faster and better starting now? Will any BP be more focused on...

Part 1: Do you have confidence in this company or not? For me, that is the question, period. I don’t think it is just about what did or didn’t happen to date, what the share price is/is not doing, the CEO, the BOD, the A or B team’s talent and motivation, KOLs, the CRO, shareholders, the drug and as...

biopearl123, that is an interesting analogy, as a 35% mortality reduction is an impressive number in this context as is Imetelstat’s results in MOS for R/R MF as well as, TI in MDS. However, I think it might be comparing apples to oranges if you are looking at MOS in R/R MF vs recovery from a virus....

biopearI123, think this is a very good discussion to have. I really like and appreciate this thread. This could also be expanded into other considerations given an MA from any entity not just the EMA although it seems obvious that the regulatory agencies work together and try to stay in sync and pro...

Thanks, biopearl for that link regarding the FDA guidelines for allowing a donor to donate blood as it sheds some light on the criticality of the availability of blood for RBCTs and the demand for over 40K RBCTs per day in the US. I am very grateful not to require RBCTs and I believe anyone would ha...

bp, your focus on the number of RBC transfusions (RBCT) seems to me to be a relatively new and un-vetted line of thought for this board and for anyone focusing on the benefits of Imetelstat. I think you are maybe shining a bright light on an issue that should be difficult to ignore and it maybe the ...