Search found 246 matches
- Sun Jul 25, 2021 12:23 am
- Forum: ImetelChat
- Topic: the wording is tricky here but important
- Replies: 6
- Views: 3392
Re: the wording is tricky here but important
Thanks again biopearl123, for taking this deeper and wider as usual! I continue to believe the reason we don’t have a partner, etc. as Dr. John Scarlett has said, the terms are not reflective of Geron/Imetelstat’s value and I suspect the starting point of the stock price will need to be considerably...
- Mon Jul 19, 2021 5:30 pm
- Forum: ImetelChat
- Topic: the wording is tricky here but important
- Replies: 6
- Views: 3392
Re: the wording is tricky here but important
Bottomline for Constellation and Curis, even MAIA, and any others trying to enter this space, they much later to the game than Geron? I wonder are they just looking for additional “targets and hits” per ashah’s link or really trying to go head-to-head with Imetelstat. Disease modification (DM) is a ...
- Sun May 30, 2021 8:56 pm
- Forum: ImetelChat
- Topic: The way forward
- Replies: 7
- Views: 5052
Re: The way forward
There is no problem if donations exceed the goal of $1000. euros. So far only 18 donations have been made so if one values this site and would like to push above the goal, IMO that would be great. With $1000 euros goal achieved, we can all breathe a sigh of relief, however that goal will only cover ...
- Tue May 25, 2021 5:30 pm
- Forum: ImetelChat
- Topic: The way forward
- Replies: 7
- Views: 5052
Re: The way forward
Thank you Fish Jr.! Very thoughtful response and perfectly on target in my view. Also, a big thank you as well to biopearl123 for his many contributions and to ashah for the generous offer to step up to moderate the ImetelChat community going forward!
- Mon May 24, 2021 9:16 pm
- Forum: ImetelChat
- Topic: Post to Fish Jr.
- Replies: 4
- Views: 1586
Post to Fish Jr.
Dear Fish Jr. I am a member on ImetelChat and FWIW, I wanted to share my take on ImetelChat with you. In my opinion, if at all possible the site should be kept up and running for the next few years. I also realize it is a long shot for this to happen given both you and biopearl123 are wanting to ste...
- Sat May 15, 2021 7:25 pm
- Forum: ImetelChat
- Topic: I think the best way to deal with this:
- Replies: 15
- Views: 5319
Re: I think the best way to deal with this:
First, a huge thank you to Fishermangents Sr./Jr. and you for all your time, effort and continuous contributions. I personally can say that this board is the only place I care to post on and find the information and analysis provided here to be of significant value to me but quite likely expect to o...
- Sun May 09, 2021 2:04 am
- Forum: ImetelChat
- Topic: In support of Cheng Ho’s arguments
- Replies: 3
- Views: 2310
Re: In support of Cheng Ho’s arguments
Ha! So granted my hunting analogy was crude at best, but I think both hunting and aiming in the right location is usually far more advantageous than speed to indiscriminate senescence or generalized coverage possibly excessively exacerbating cytopenias. Which I don’t believe was or could be fairly a...
- Sun May 09, 2021 1:00 am
- Forum: ImetelChat
- Topic: Partner for European Rights
- Replies: 4
- Views: 2542
Re: Partner for European Rights
I personally am not opposed to a partnership, however on the boards, we tend to generalize the partnership agreement which leaves so much to ones imagination or not. As we know, not all partnerships workout but they can have advantages and/or disadvantages. As JS/BOD/Geron gains traction in the regu...
- Fri May 07, 2021 9:09 pm
- Forum: ImetelChat
- Topic: In support of Cheng Ho’s arguments
- Replies: 3
- Views: 2310
Re: In support of Cheng Ho’s arguments
Thanks again biopearl for posting these insightful links. This research paper, published in November 2018 and to date has not been updated. One has to wonder if JNJ incorrectly interpreted this information prior to the negative CD. Certainly an interesting paper, however, IMHO the goal seems to be r...
- Tue Apr 20, 2021 6:39 pm
- Forum: ImetelChat
- Topic: New Tefferi paper
- Replies: 2
- Views: 2043
Re: New Tefferi paper
Thanks for sharing. Excellent and very interesting work again by Dr. Ayalew Terreri. Seems like it’s been a while since he’s shown up on our radar like this and clearly provided a significant level of support for Imetelstat. While I appreciate the contribution, It’s a stretch to say Geron blew anyth...
- Thu Mar 25, 2021 6:55 pm
- Forum: ImetelChat
- Topic: It all comes down to confidence
- Replies: 1
- Views: 1589
Re: It all comes down to confidence
Part 2: Over the next couple years Geron will complete building the vertical organization and infrastructure to deliver Imetelstat to patients with hematologic cancers and eventually to patients with other malignancies. Will any BP do it faster and better starting now? Will any BP be more focused on...
- Thu Mar 25, 2021 6:54 pm
- Forum: ImetelChat
- Topic: It all comes down to confidence
- Replies: 1
- Views: 1589
It all comes down to confidence
Part 1: Do you have confidence in this company or not? For me, that is the question, period. I don’t think it is just about what did or didn’t happen to date, what the share price is/is not doing, the CEO, the BOD, the A or B team’s talent and motivation, KOLs, the CRO, shareholders, the drug and as...
- Tue Aug 25, 2020 10:43 pm
- Forum: ImetelChat
- Topic: Quote from Dr. Stephen Hahn FDA Commissioner
- Replies: 3
- Views: 2531
Re: Quote from Dr. Stephen Hahn FDA Commissioner
biopearl123, that is an interesting analogy, as a 35% mortality reduction is an impressive number in this context as is Imetelstat’s results in MOS for R/R MF as well as, TI in MDS. However, I think it might be comparing apples to oranges if you are looking at MOS in R/R MF vs recovery from a virus....
- Sat Aug 15, 2020 11:34 pm
- Forum: ImetelChat
- Topic: Re EU MA
- Replies: 13
- Views: 6640
Re: Re EU MA
biopearI123, think this is a very good discussion to have. I really like and appreciate this thread. This could also be expanded into other considerations given an MA from any entity not just the EMA although it seems obvious that the regulatory agencies work together and try to stay in sync and pro...
- Wed Jun 17, 2020 6:35 am
- Forum: ImetelChat
- Topic: Imagine reading this
- Replies: 6
- Views: 4496
Re: Imagine reading this
Thanks, biopearl for that link regarding the FDA guidelines for allowing a donor to donate blood as it sheds some light on the criticality of the availability of blood for RBCTs and the demand for over 40K RBCTs per day in the US. I am very grateful not to require RBCTs and I believe anyone would ha...
- Tue Jun 16, 2020 8:13 am
- Forum: ImetelChat
- Topic: Imagine reading this
- Replies: 6
- Views: 4496
Re: Imagine reading this
bp, your focus on the number of RBC transfusions (RBCT) seems to me to be a relatively new and un-vetted line of thought for this board and for anyone focusing on the benefits of Imetelstat. I think you are maybe shining a bright light on an issue that should be difficult to ignore and it maybe the ...
- Sat May 23, 2020 10:11 pm
- Forum: ImetelChat
- Topic: Thoughts on this interesting take from YMB:
- Replies: 10
- Views: 5825
Re: Thoughts on this interesting take from YMB:
Given our CEO is shrewd and a risk taker and heavily vested in making the best / right steps in bringing Imetelstat to market in the greatest way possible, I think we can rest assured that there is a lot of “out of the box” thinking going on right now. These discussions certainly include funding, pa...
- Wed Apr 22, 2020 11:52 pm
- Forum: ImetelChat
- Topic: Patience and balance are virtues needed for the Geron journey
- Replies: 9
- Views: 6065
Re: Patience and balance are virtues needed for the Geron journey
Yes, patience is hard in this space and time, as well as elsewhere for some of us, myself included. And I don’t mean to be overly philosophical with these posts and realize with so many people, patients and investors alike, struggling with their interest and participation in Geron / Imetelstat has b...
- Tue Apr 14, 2020 12:28 am
- Forum: ImetelChat
- Topic: Patience and balance are virtues needed for the Geron journey
- Replies: 9
- Views: 6065
Re: Patience and balance are virtues needed for the Geron journey
Thanks bucbeard for your kind response as always. I certainly would feel much more at home on the bluffs in hunting gear than in a lounge chair on Turtle Island but who knows what the impending may bring. And either would be a welcome venue for meeting up with you somewhere in the future. And thanks...
- Sat Apr 11, 2020 1:25 am
- Forum: ImetelChat
- Topic: Patience and balance are virtues needed for the Geron journey
- Replies: 9
- Views: 6065
Re: Patience and balance are virtues needed for the Geron journey
Part 3 of 3: Now we should all come back to face our confirmation biases, especially where our fortunes are at stake. I think a significant part of our CB flows from our nature versus the data, results or ideas presented. However, in regards to our Geron investments, I believe most of us will ultima...