Search found 40 matches

by Dogonenuts
Sun Mar 25, 2018 5:29 am
Forum: ImetelChat
Topic: Just saw a reference to a 2017 article in Blood
Replies: 2
Views: 2726

Just saw a reference to a 2017 article in Blood

on the possibility of Jakfi enhancing evolution of mutations or covering these up with temporary symptomatic relief. If either turns out to be true, imet could catapult to primary tx rapidly. Google jakafi evolution of mutations and you will get to the article.
by Dogonenuts
Sun Mar 25, 2018 5:26 am
Forum: ImetelChat
Topic: Does anyone have any idea how transparent Janssen
Replies: 1
Views: 2136

Does anyone have any idea how transparent Janssen

Has to be with Geron on other things they may be tinkering with? We all know about AML possibilities, but if Janssen is already doing anything preclinical in pushing imet as a truly platform drug do they have to divulge this? Imet as a platform would push the value into the stratosphere obviously.
by Dogonenuts
Fri Mar 23, 2018 2:10 am
Forum: ImetelChat
Topic: EMA Prime
Replies: 4
Views: 8440

Re: EMA Prime

In regards to the original post, my impression that primary designation was definitely open in Europe for MDS, not MF necessarily, though one could see Jak inhibitors already on a slippery slope worlwide, but that is just my conjecture.
by Dogonenuts
Wed Mar 21, 2018 10:04 pm
Forum: ImetelChat
Topic: In case Sdraw reads this board--repost from SA
Replies: 3
Views: 5218

Re: In case Sdraw reads this board--repost from SA

In regards to skipping a P3 with imetelstat, one only has to look back at SRPT. They got a drug approved that really is questionable whether it works at all. This drug passed on anecdotal performance in 12 patients with no controls. Truly this is a friendlier FDA, and I will not be surprised to see ...
by Dogonenuts
Tue Mar 20, 2018 5:56 pm
Forum: ImetelChat
Topic: Take aways from today's cc
Replies: 5
Views: 4920

Re: Take aways from today's cc

Quoting BioMedTech from SA on his conversation with Gern Inv relations person, “we should not infer that Median OS would be reached by end of Q2!”

We were right in our interpretation of Chip’s remark.
by Dogonenuts
Tue Mar 20, 2018 3:00 am
Forum: ImetelChat
Topic: Take aways from today's cc
Replies: 5
Views: 4920

Re: Take aways from today's cc

If I could add acouple of personal meaningful takeaways after listening to and reading CC transcript. Chip seemed very confident that OS would be known to be very meaningful by the end of June, not because it would be reached, but the original endpoint would have been reached. He did mention death r...
by Dogonenuts
Sun Mar 18, 2018 2:00 pm
Forum: ImetelChat
Topic: Question to pose
Replies: 3
Views: 2563

Re: Question to pose

Oh, I know there would have to be some studies. Just thinking where this thing might go over the next few years and why JnJ might jump whole hog for GERN.
by Dogonenuts
Sat Mar 17, 2018 8:34 pm
Forum: ImetelChat
Topic: Question to pose
Replies: 3
Views: 2563

Question to pose

With the OS in the Imbark trial now up to 19-21 months, would a new treatment paradigm be worth considering? Would not combination therapy from the outset seem more reasonable, though expensive? Or, even imet from the start and splenectomy if a bonemarrow biopsy and aspirate show reversal of marrow ...
by Dogonenuts
Sat Mar 03, 2018 4:46 pm
Forum: ImetelChat
Topic: Frontline MF vs R/R MF spleen size
Replies: 6
Views: 4662

Re: Frontline MF vs R/R MF spleen size

If reversal of bonemarrow fibrosis is the result of imet tx, it would seem that splenectomy for sumptomatic relief could then be a viable option should this not occur with drug tx. I can’t beleive the drs did a splenectomy in the pt referred to in the op as this was taking away their only functionin...
by Dogonenuts
Wed Feb 28, 2018 8:10 pm
Forum: ImetelChat
Topic: Geron’s fiduciary responsibility
Replies: 4
Views: 3763

Re: Geron’s fiduciary responsibility

While our CEO isnot the best communicator, being the head of a publicaly traded company he has to be ultra careful that he does not mislead anyone in a short or long fashion from an Sec legal standpoint.I am sure that J&J has another layer of shackles on him as well as they don’t want another Pharma...
by Dogonenuts
Tue Feb 13, 2018 7:51 pm
Forum: ImetelChat
Topic: Current 1Q18 MF median OS review and related upcoming reporting
Replies: 7
Views: 5833

Re: Current 1Q18 MF median OS review and related upcoming reporting

Ah, I was afraid of that. We all will pass one day, but I would hate to think that the trials caused him to come off of the drug when it was helping him, and led to his passing.
by Dogonenuts
Mon Feb 12, 2018 12:18 am
Forum: ImetelChat
Topic: Dr. Alessandro Vannucchi about imetelstat
Replies: 1
Views: 2253

Re: Dr. Alessandro Vannucchi about imetelstat

About to watch this, but both drugs can cause thrombocytopenia, so I doubt any overlapping combo tx would be contemplated. Maybe alternating, as in getting these dz under control, then switching to the jak inhibitor for some symptomatice relief seems logical, but probably too simplematic for today’s...
by Dogonenuts
Mon Feb 12, 2018 12:14 am
Forum: ImetelChat
Topic: Current 1Q18 MF median OS review and related upcoming reporting
Replies: 7
Views: 5833

Re: Current 1Q18 MF median OS review and related upcoming reporting

Does anyone here know if Irishtrader’s husband, John, was able to get back on Imet, or is still with us in life? I sure hope so, but have not seen an irish post in a long time, so I amfearing the worst for them. This stuff goes way beyond investing.
by Dogonenuts
Sat Feb 10, 2018 1:25 am
Forum: ImetelChat
Topic: Current 1Q18 MF median OS review and related upcoming reporting
Replies: 7
Views: 5833

Re: Current 1Q18 MF median OS review and related upcoming reporting

It is a shame that all the info in these CTs has to be so closely guarded. Seems there should be some mention of numbers of original pts still in the trials and reference to their initiation in the trial. This should be fair game as we know the OS for r/r patients is short.

Nuts
by Dogonenuts
Sat Feb 10, 2018 1:22 am
Forum: ImetelChat
Topic: Fishermagnets response to SA article today
Replies: 2
Views: 2584

Fishermagnets response to SA article today

Fish, I would love to hear your thoughts on the hit article posted today on SA. I scanned thru the qtrly Sec fillings mentioned but did not see mention of deaths in either trial admitted to by Jansenn. The article was mainly a rehash of difficulties in applying Imet to solid tumors in years back. Ho...
by Dogonenuts
Thu Nov 16, 2017 6:20 pm
Forum: ImetelChat
Topic: Thoughts on this week's presentation
Replies: 7
Views: 6077

Re: Thoughts on this week's presentation

Bio, thanks for the summary and thoughts. I listened to the webcast, and my impression was that Scarlet seemed a lot more confident when referring to JnJ than he has in a long time. I think he knows we have a winner on our hands. It is just going to be a matter of how big a winner. I am an MD, but i...
by Dogonenuts
Sun Apr 30, 2017 7:05 pm
Forum: ImetelChat
Topic: Shine a light!!
Replies: 7
Views: 5580

Re: Shine a light!!

Irish, I have been following your and John's story for some time now. I appreciate the update here recently and assure you that you and John are in my prayers. If I can inject a little humor, it is always good for us according to the late Paul Harvey, while us investors are like chickens with an egg...
by Dogonenuts
Wed Apr 19, 2017 9:45 pm
Forum: ImetelChat
Topic: Introduction
Replies: 18
Views: 16624

Introduction

First of all thanks for letting me onto this message board. As an introduction, I have been following Imetelstat since the Mayo paper was made public. I am a physician, though not in hematology, but the CRs and PRs caught my attention, as this is a rarely infrequent claim in the biotech world. I bec...
by Dogonenuts
Fri May 13, 2016 3:46 am
Forum: ImetelChat
Topic: A dusting of breadcrumbs
Replies: 7
Views: 4585

Re: A dusting of breadcrumbs

Check out study number 5 on the CT site. Has been ongoing since Nov 2012. That is 3 1/2 years with some of those pts still surviving. I know this was the study that put Imetelstat on the map.. Must be still working for some. No new info, but meaningful.
by Dogonenuts
Tue May 10, 2016 7:37 pm
Forum: ImetelChat
Topic: GERN buy-out
Replies: 4
Views: 6366

Re: GERN buy-out

What got me, and why I have stayed in G for a long time was the report at the ASH meeting where they said they had seen some complete responses for the first time. That was all I needed to hear. I am not in oncology, but I do know that a CR is the Holy Grail in cancer research. The chance that this ...