Search found 202 matches

by cheng_ho
Thu Apr 29, 2021 8:09 pm
Forum: ImetelChat
Topic: Bill, Ama se comondo
Replies: 2
Views: 2254

Re: Bill, Ama se comondo

Ha, no, and even putting that into Google only brought me back to this post.
by cheng_ho
Thu Apr 29, 2021 8:04 pm
Forum: ImetelChat
Topic: Contest: Name that drug
Replies: 10
Views: 4204

Re: Contest: Name that drug

Unobtainastat

ALTagen (remember our Shay-Wright lab 2004 paper on cancer evolving around imetelstat)

6-thio-dG-stat (might as well go with the winner)

NeedsACombostat

Telomeclast

Bankruptamerase
by cheng_ho
Mon Apr 19, 2021 5:10 pm
Forum: ImetelChat
Topic: New Tefferi paper text (4)
Replies: 0
Views: 2015

New Tefferi paper text (4)

lenalidomide have also been reported in MDS-RS.21 By contrast, as was underlined in the current edition of AJH by Montalban-Bravo et al,2 as well as noted in previous publications,15 therapeutic success with hypomethylating agents in MDS/MPN-RS-T has been less than stellar and not much better in MDS...
by cheng_ho
Mon Apr 19, 2021 5:09 pm
Forum: ImetelChat
Topic: New Tefferi paper text (3)
Replies: 0
Views: 1924

New Tefferi paper text (3)

with MDS-RS, three (38%) of eight transfusion-dependent patients became transfusion-independent at a median time of 11 weeks and their response lasted for a median of 28 weeks (range, 9–37); one of the three patients also had resolution of leukocytosis and thrombocytosis. From mutation standpoint, 3...
by cheng_ho
Mon Apr 19, 2021 5:08 pm
Forum: ImetelChat
Topic: New Tefferi paper text (2)
Replies: 0
Views: 1992

New Tefferi paper text (2)

In a phase-3, placebo-controlled MEDALIST trial (n=229) of transfusion-dependent patients with low/intermediate risk MDS-RS and who failed treatment with erythropoiesis stimulating agents (ESAs) or serum erythropoietin (Epo) level of >200U/L, 28% of patients in the luspatercept treated group vs 8% i...
by cheng_ho
Mon Apr 19, 2021 5:03 pm
Forum: ImetelChat
Topic: New Tefferi paper text (1)
Replies: 0
Views: 1716

New Tefferi paper text (1)

he World Health Organization classification system recognizes the presence of ring sideroblasts (RS), in excess of 15% (or 5% in the presence of SF3B1 mutation) of bone marrow erythroid precursors, as a distinguishing feature to classify myelodysplastic syndromes with RS (MDS-RS) and myelodysplastic...
by cheng_ho
Mon Apr 19, 2021 4:58 pm
Forum: ImetelChat
Topic: New Tefferi paper
Replies: 2
Views: 2043

New Tefferi paper

https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.26197 "Taken together, the aforementioned data suggested a broader disease-modifying activity for imetelestat in myeloid neoplasms, with or without RS, and possibly influenced by the presence or absence of specific mutations. Accordingly, imeteles...
by cheng_ho
Thu Apr 01, 2021 10:06 pm
Forum: ImetelChat
Topic: MAIA Biotechnology has a combo trial
Replies: 5
Views: 3291

Re: MAIA Biotechnology has a combo trial

MAIA is still taking investors... you just have to be a real person (i.e., someone that can meet the SEC "Qualified Investor" standard). Obviously that rules out all of us that lost our money in the Discontinuation, but there are about 18.6 million Americans that qualify: https://spendmenot.com/blog...
by cheng_ho
Thu Apr 01, 2021 4:21 pm
Forum: ImetelChat
Topic: In the interest of transparency
Replies: 3
Views: 1875

Re: In the interest of transparency

Stockholm Syndrome is a terrible thing. If only humans would stop selling each other out to suck up to the powerful.
by cheng_ho
Thu Apr 01, 2021 4:20 pm
Forum: ImetelChat
Topic: This one’s for you too, Bill (cheng ho)
Replies: 3
Views: 2989

Re: This one’s for you too, Bill (cheng ho)

Andrew, the issue with this patent is prior art. Yes, it includes 6-thio-dG... BUT, that chemical was already used in oncology a few times decades ago.

So it's up to a long, expensive patent-court duel with MAIA... and Regeneron.
by cheng_ho
Mon Mar 29, 2021 6:51 pm
Forum: ImetelChat
Topic: Letter for Shareholder Meeting from biopearl
Replies: 2
Views: 1666

Re: Letter for Shareholder Meeting from biopearl

Will this be another virtual meeting? It would be pretty dangerous to ask about 6-thio-dG in person ;)

He'll evade the question anyway, but better to ask two years late than not at all. Stockholders deserve an answer.
by cheng_ho
Mon Mar 29, 2021 6:44 pm
Forum: ImetelChat
Topic: MAIA Biotechnology has a combo trial
Replies: 5
Views: 3291

Re: MAIA Biotechnology has a combo trial

YES! Who owns the 6-thio-dG IP... if there is any. GERN has a patent... but 6-thio-dG has some clinical oncology use from before the patent. And of course as usual, Geron has said nothing at all about an IP agreement. So, is MAIA a possible Geron savior... or just another typical pharma ten-year law...
by cheng_ho
Wed Mar 24, 2021 4:32 pm
Forum: ImetelChat
Topic: What Didn't Happen
Replies: 7
Views: 2571

Re: What Didn't Happen

Good summary. In a lot of alternate universes, imetelstat went into combo trials on blood cancer in 2006, and at this point is obsolete, having been replaced by 6-thio-dG or something better.

We're stuck in the universe where Skynet has no competition from carbon-based life.
by cheng_ho
Tue Mar 16, 2021 8:20 pm
Forum: ImetelChat
Topic: MAIA Biotechnology has a combo trial
Replies: 5
Views: 3291

MAIA Biotechnology has a combo trial

They're using Dr. Shay's 6-thio-dG in combination with a Regeneron antibody: https://www.businesswire.com/news/home/20210202005307/en/MAIA-Biotechnology-Inc.-Announces-Clinical-Supply-Agreement-with-Regeneron-for-Phase-12-Clinical-Trial-Evaluating-THIO-in-Sequential-Administration-with-Libtayo%C2%AE...
by cheng_ho
Fri Mar 12, 2021 5:07 pm
Forum: ImetelChat
Topic: Over/Under on Full enrollment in MDS
Replies: 6
Views: 4566

Re: Over/Under on Full enrollment in MDS

I agree, in September GERN will finally have all the patients for one trial. This delay was mostly the EU's fault for its pathetically bad vaccination programs. They are even worse than US FDA/CDC ineptitude. And of course, only Turkey has made any use of the successful Phase 3 on NAD+ boosting vs. ...
by cheng_ho
Fri Mar 12, 2021 5:00 pm
Forum: ImetelChat
Topic: This one’s for you too, Bill (cheng ho)
Replies: 3
Views: 2989

Re: This one’s for you too, Bill (cheng ho)

Yes, Geron's patents always stand in the way of any real company trying to cure cancer.
by cheng_ho
Mon Feb 01, 2021 8:37 pm
Forum: ImetelChat
Topic: Why does Geron's presentation show EU approval after FDA?
Replies: 3
Views: 2456

Re: Why does Geron's presentation show EU approval after FDA?

Statistically, that would be the normal order. The EMA is, on average, even slower than the US to approve drugs and vaccines. For example, look at the vaccination rate by country. Most EU countries have barely started... and that's while the US gave everyone else a head start by not approving the AZ...
by cheng_ho
Thu Jan 28, 2021 10:50 pm
Forum: ImetelChat
Topic: short interest
Replies: 17
Views: 8463

Re: short interest

Well, it's moot now, FC... the short interest fell by 37 million shares.

So, in theory, that's statistically a great sign. If this weren't Geron, one could imagine that the smart money saw something good happening in the near future.
by cheng_ho
Tue Jan 19, 2021 6:13 pm
Forum: ImetelChat
Topic: Relevant quote from the Holmstrom article
Replies: 2
Views: 2403

Re: Relevant quote from the Holmstrom article

Good find.

Of course the relevant protein(s) could be found any day, but interesting to see the current state of the field.
by cheng_ho
Tue Jan 19, 2021 6:11 pm
Forum: ImetelChat
Topic: Musings on Geron's current and future position
Replies: 3
Views: 3140

Re: Musings on Geron's current and future position

You'll recall that they made their SARS-CoV-2 vaccine in TWO DAYS. The only delay in getting it out was from FDA forcing them NOT to pay for trial volunteers from high-risk groups.... so they were forced to give vaccines to 35,000 mostly younger white women, thus not getting enough cases. Had they t...