Search found 348 matches

by Ryan
Sat Mar 02, 2024 7:39 pm
Forum: ImetelChat
Topic: Kudos
Replies: 12
Views: 2427

Re: Kudos

biopearl123 wrote:
Fri Mar 01, 2024 11:32 pm
Kudos to Stig, you make your fellow board members proud and of course to Sdraw!
The med school comment was well-written and thorough.

But why did you shout out Sdrawkcabeman? Do you think he wrote a comment? I think he disappeared a long time ago which makes you worry about his health.
by Ryan
Fri Mar 01, 2024 3:55 pm
Forum: ImetelChat
Topic: The road to the front of line
Replies: 2
Views: 881

Re: The road to the front of line

Well said, but…

Won’t be second in line for long … how do you define “long”?? :D
by Ryan
Wed Feb 28, 2024 9:50 pm
Forum: ImetelChat
Topic: PPS
Replies: 79
Views: 133495

Re: PPS

Great call today. The excellence and experience of our personnel, thumbs up. Mentions of the Lancet. Question about the ODAC comment from the heme experts, nice one. And of course the pps. Hence why I’m responding in this thread. Spike up and now way down. Looks like ~12 million will trade today. Po...
by Ryan
Tue Feb 27, 2024 4:48 am
Forum: ImetelChat
Topic: A blessing from the hepatologists Major hat tip to Wildrides YMB
Replies: 5
Views: 1534

Re: A blessing from the hepatologists Major hat tip to Wildrides YMB

The Anonymous patient from Leipzig Hospital (Germany) submission is also worth an eye-opening read. Excited.
by Ryan
Tue Feb 27, 2024 4:42 am
Forum: ImetelChat
Topic: A blessing from the hepatologists Major hat tip to Wildrides YMB
Replies: 5
Views: 1534

Re: A blessing from the hepatologists Major hat tip to Wildrides YMB

Wow, when somebody writes “my life depends on it”, it gives you pause and makes you realize the gravity of this decision. Two units every 7-10 days, that’s difficult. I also imagine s/he does not feel great by day 6 after infusion. The fact that the Doctor was so bold as to tell her/his patient abou...
by Ryan
Mon Feb 26, 2024 10:44 pm
Forum: ImetelChat
Topic: The cost to develop a new drug
Replies: 4
Views: 1085

Re: The cost to develop a new drug

My guesstimate is Geron is at about $1.7 Billion since 1997, specific to telomerase drug development, give or take $300 Million.
by Ryan
Mon Feb 26, 2024 10:42 pm
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3989

Re: meanwhile, back on topic

9 Million shares today :roll:
by Ryan
Thu Feb 22, 2024 11:21 pm
Forum: ImetelChat
Topic: Inducing
Replies: 1
Views: 646

Re: Inducing

Meanwhile, B.O.T.: I'm not mad at them. The new hires I mean. (Or the HR group handing out the contracts.) All I have seen are some seriously qualified individuals in the rarified air of the biotech industry. These professionals are certainly not a dime a dozen, and Dr. Scarlet and the Board are cle...
by Ryan
Wed Feb 21, 2024 2:34 am
Forum: ImetelChat
Topic: A wonderful summation of the state of things
Replies: 4
Views: 890

Re: A wonderful summation of the state of things

I think it’s a foregone conclusion that the reason for standard review is because Imet is a New Molecular Entity and thus a committee review was warranted.
by Ryan
Mon Feb 19, 2024 12:56 am
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3989

Re: meanwhile, back on topic

Meanwhile, I see that, if there is a partial government shutdown on March 2nd, which will happen if the disfunctional Congress doesn’t pass either a continuing resolution or a budget…… the FDA is one of the agencies in that partial shutdown. Wouldn’t that just be Geron’s luck, if the March Adcom has...
by Ryan
Sat Feb 17, 2024 4:54 pm
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3989

Re: meanwhile, back on topic

I saw the filings of employee options grants … early than prior years. Let’s hope (!) that this means the pps can finally make a move …. Waiting not patiently…
by Ryan
Wed Feb 14, 2024 8:35 pm
Forum: ImetelChat
Topic: meanwhile, back on topic
Replies: 25
Views: 3989

Re: meanwhile, back on topic

Deep Track Capital is a Greenwich, Connecticut-based investment firm focused exclusively on the life sciences industry. We develop long term partnerships with management teams of leading innovative public and pre-IPO biotechnology companies. In addition to capital, we seek to invest our time and ex...
by Ryan
Wed Feb 14, 2024 8:28 pm
Forum: ImetelChat
Topic: Will NOAA take action while the FDA stands on the sidelines?
Replies: 14
Views: 1875

Re: Will NOAA take action while the FDA stands on the sidelines?

My only quibble here is the use of the word “lowly”. Horseshoe Crabs outlasted the dinosaurs and I’m sure have seen epochs and 1000 year periods that were quite dangerous in those hundreds of millions. So I am hoping they survive our species’ ingenious idiocy. From Caribou in Canada to Gorillas in A...
by Ryan
Thu Feb 08, 2024 5:33 pm
Forum: ImetelChat
Topic: January Presentation
Replies: 4
Views: 1469

Re: January Presentation

Does the ODAC panel announce their recommendation on the day of the meeting?
by Ryan
Wed Feb 07, 2024 11:58 pm
Forum: ImetelChat
Topic: Magro again
Replies: 4
Views: 1032

Re: Magro again

Thanks for posting link. Here is what Dr. Zeidan wrote on Twitter: A very sad end to the story of Magrolimab in #MDSsm and #AMLsm. There is a lot to be learned here not only in terms of the science of the CD47 pathway, but also in terms of trial design, endpoints, & overall drug development approach...
by Ryan
Mon Feb 05, 2024 9:37 pm
Forum: ImetelChat
Topic: January Presentation
Replies: 4
Views: 1469

January Presentation

January presentation is impressive to me:

https://s201.q4cdn.com/710325604/files/ ... 1-7-24.pdf
by Ryan
Sat Feb 03, 2024 7:46 pm
Forum: ImetelChat
Topic: ADCOM
Replies: 96
Views: 292249

Re: ADCOM

Go play some Tom Petty. “The waaaaaaaa—aaaitin is the hardest part.”
by Ryan
Wed Jan 31, 2024 9:21 pm
Forum: ImetelChat
Topic: less competition
Replies: 5
Views: 1770

Re: less competition

My take on your question about Dr. Steensma's intent, which of course is an uneducated guess: I think High Risk and Low Risk MDS are just different diseases. You know that, and I think in that is the reason. This expert is focusing on the High Risk designation, and is not considering imet yet withou...
by Ryan
Wed Jan 31, 2024 4:48 pm
Forum: ImetelChat
Topic: less competition
Replies: 5
Views: 1770

Re: less competition

Click the link to see the reaction from Dr. Steensma. (Don’t need to login to see…) https://twitter.com/DavidSteensma/status/1752682957171474463 “Discouraging news today: #MDSsm sabatolimab+azacitidine STIMULUS-MDS2 trial was negative (no OS benefit vs aza alone.) It has been so long since there was...
by Ryan
Tue Jan 30, 2024 4:13 pm
Forum: ImetelChat
Topic: Official 8k notice of ODAC advisory meeting
Replies: 4
Views: 1373

Re: Official 8k notice of ODAC advisory meeting

At least it’s on that Thursday and not Friday…

Beware of the Ides of March. :lol:

Onwards…