ImetelChat

Point taken, a black box warning is not the end of the world for Imetelstat and would probably not impair appropriate usage of the drug. In my area, drugs like amiodarone, Sotolol, even digitalis would kill in the hands of the inexperienced. Oncologists use very strong drugs and Imetelstat would not...

Pretty scary, that example. No doubt the analysts have financial models with and without the black box warnings and are very interested in whether one might be issued. Considering that a black box warning is conferred when there is are serious adverse reactions that “may lead to death or serious inj...

Operation Kmall was a Herculean undertaking and was a great success lo those many years ago. Our service men deserve the best of care, not to mention the highest respect. When I see a Gold Star family disrespected or a national hero and fine person who has served our country on so many levels like J...

Eloquent, heartfelt, sincere and well informed. Worth a visit to the FDA comments board to review this. Major kudos, sir. On another note, Just a reminder that the cytopenias are not related to toxicity like many chemo agents, this drug does not destroy the bone marrow, it heals it. It’s pretty stra...

https://www.regulations.gov/document/FDA-2024-N-0016-0001 Comments submitted before Feb 29th will be presented to the committee. Comments after that date will be taken into consideration by the FDA. If you or anyone you know want their comments considered, there is a time deadline. So far only a few...

Ryan, are you surprised? I think this is the tip of the iceberg.

https://www.regulations.gov/docket/FDA- ... 6/comments

More to come...

Yes we have seen a lot of dilution but how much would Janssen have spent to do the same for Imetelstat?

https://www.genengnews.com/gen-edge/the ... 3-billion/

I have reviewed the recent discussion. We have much to learn from other species and as Jerry Garcia would say, “the wonders of nature”. Kmall’s posts remind us of the amazing beauty around us and how the species intertwine and the respect we should have for our fragile ecosystem. Who would know that...

I am traveling and will give this thread the scrutiny it deserves when I can

This is the opening paragraph of a paper by Chandhok and Sekeres in "Leukemia" Feb 15th which I can't copy here sums up the sorry state of affairs in the current treatment of LR/MDS and confirms the absence of data to support improved survival (with current treatment) and the dreadful dependence of ...

Kmall, I stand happily corrected on both points

Some as asked for a reckoning of side effects from Imetelstat. Fair enough. I think however having some framework that allows evaluation of alternatives help with perspective. Let’s start with the side effects of blood transfusions: 1. Volume overload (many patients with MPD have concurrent vascular...

The editorial written by Dr. Patniak is summarized in my Dec 5th post. You do have access if you wish, there is a modest fee to Lancet for time limited access.

LWS, like many things in life, this is not binary. It might be valuable to go back and review the Mayo editorial in Lancet which tries to balance a ringing endorsement with an an examination of the potential flaws in the IMerge study and the cautionary approach that must be used with any completely ...

Jay, I could be wrong but the way I read it is that these are options to buy stock at 2.10 anytime over the next ten years were awarded as a from of incentive/compensation. They own the options to buy. If the stock goes up it’s a bargain, they can buy at 2.10 if it goes down the options are worthles...

These are option awards with a 2034 expiration date.

Seedylemon, I think it might be worth trying to clarify your post. Dr. Scarlett along with other officers received option awards that can be exercised for a certain price anytime over the next ten years. That is not the same as buying shares outright or exercising options to guarantee a specific pri...

Jay I have only seen recent options awarded but not redeemed. I probably missed the ones that were redeemed can you remind us? Thanks, bp