Search found 1665 matches
- Sat Nov 04, 2023 11:11 pm
- Forum: ImetelChat
- Topic: Nature Article
- Replies: 3
- Views: 1771
Re: Nature Article
Mr.G, good question. As you can see on clin trials site, there have been many solid tumor studies from over a decade ago that failed. Nonetheless less, new combinations might be tried or new ways up inhibit telomerase (e.g. MAIA or Geron’s as yet to be revealed, oral agent in early development) coul...
- Sat Nov 04, 2023 9:04 pm
- Forum: ImetelChat
- Topic: Nature Article
- Replies: 3
- Views: 1771
Re: Nature Article
Mistergern, yes this seminal article article was first posted on YMB (not by me) and subsequently reposted here on Oct 31st. It’s pretty amazing work that reflects 5 years of nonstop hard work by Dr. Lane and his team with special recognition to the lead author Dr. Claudia Bruedigam. While this is a...
- Fri Nov 03, 2023 7:27 pm
- Forum: ImetelChat
- Topic: Review or not to review.
- Replies: 3
- Views: 2830
Re: Review or not to review.
Jay, we were also led to believe priority review was a strong possibility. It didn’t happen. It’s not impossible that the FDA will just approve outright but I wouldn’t hold my breath.
- Fri Nov 03, 2023 3:28 pm
- Forum: ImetelChat
- Topic: Looks like analyst's have finally done their homework.....
- Replies: 1
- Views: 931
Re: Looks like analyst's have finally done their homework.....
Kmall, I was amazed at your numbers from several years ago, thinking them perhaps too optimistic. Now they look spot on and sagacious. Remarkable. Anyway, you’re gonna need a bigger boat. The question is will it be in this life or the next…. :). As always, Thanks for your massive contributions here....
- Fri Nov 03, 2023 3:01 am
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 292158
Re: ADCOM
JS says ADCOM 4 to 6 weeks pre PDUFA
- Thu Nov 02, 2023 10:28 pm
- Forum: ImetelChat
- Topic: Takeaways from today's update....
- Replies: 2
- Views: 999
Re: Takeaways from today's update....
HI thank you for this distillation. I count 4 abstracts. One oral and three posters. It’s easy to over count with the ASH format such as it is.
- Thu Nov 02, 2023 6:37 pm
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 292158
Re: ADCOM
LWS, enough. We have no idea when the ADCOM meeting will be scheduled. Much more likely to be scheduled much closer to June date. Wishing and repetition does not and will not make it so. You are getting very close to requiring the red pencil.
- Thu Nov 02, 2023 4:11 am
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 292158
Re: ADCOM
KT, to be sure, John can’t be pleased with the FDA and neither should we, or doctors, or patients, or lenders, (oh wait they get more months of interest as the loan payback is delayed) or Wall Street (oh wait, they get to issue more stock and take large fees). So with some exceptions, no one is happ...
- Wed Nov 01, 2023 9:09 pm
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 292158
Re: ADCOM
Where you see agreement, I can assure you there is no agreement and won’t be until the FDA says there is.
- Wed Nov 01, 2023 7:26 pm
- Forum: ImetelChat
- Topic: So wonderful to see…
- Replies: 2
- Views: 1288
So wonderful to see…
So wonderful to see Claudia’s youthful crackling intelligence and enthusiasm and Steven’s gravitas. 5 years of hard lab work, no vacations and the reward of a discovery of a new pathway! Can’t wait for the abstracts and preliminary clinical results. Kudos! (Nobel committee take note…)
- Wed Nov 01, 2023 7:20 pm
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 292158
Re: ADCOM
What you are missing is that no amount of wishful thinking will change the FDAs schedule.
- Wed Nov 01, 2023 4:25 pm
- Forum: ImetelChat
- Topic: Link to Drs. Lane and Bruedigam
- Replies: 5
- Views: 2399
Re: Link to Drs. Lane and Bruedigam
The case study at the end was unusual as it said nothing about how this lovely lady actually did with Imetelstat. Response? Remission? I suspect heavy censorship until presentations at scientific meetings.
- Tue Oct 31, 2023 6:48 pm
- Forum: ImetelChat
- Topic: Link to Drs. Lane and Bruedigam
- Replies: 5
- Views: 2399
- Tue Oct 31, 2023 3:34 am
- Forum: ImetelChat
- Topic: New article hit tip to several on YMB
- Replies: 3
- Views: 1546
Re: New article hit tip to several on YMB
Gotta love that!
- Tue Oct 31, 2023 12:02 am
- Forum: ImetelChat
- Topic: New article hit tip to several on YMB
- Replies: 3
- Views: 1546
- Mon Oct 30, 2023 3:34 pm
- Forum: ImetelChat
- Topic: More MAIA drug development
- Replies: 0
- Views: 6284
More MAIA drug development
https://finance.yahoo.com/news/maia-bio ... 00410.html
Sergei hard at work. HI or CKTC if you are around perhaps revisiting the old Geron patents re Thio might be interesting.
Sergei hard at work. HI or CKTC if you are around perhaps revisiting the old Geron patents re Thio might be interesting.
- Thu Oct 26, 2023 10:40 pm
- Forum: ImetelChat
- Topic: Nov 2nd earning call
- Replies: 9
- Views: 3412
Nov 2nd earning call
Nov 2nd:earnings call
Nov 2nd: ASH abstract release
Nov 2nd: ASH abstract release
- Thu Oct 26, 2023 3:34 pm
- Forum: ImetelChat
- Topic: Is this new ?
- Replies: 2
- Views: 1513
Re: Is this new ?
Yes. See topic “more support “ Oct 17th. Lots of familiar names. Was sorry to see MAIA tank on good news. Have never felt ownership of 6 THIO fully settled.
- Wed Oct 25, 2023 5:35 pm
- Forum: ImetelChat
- Topic: ADCOM
- Replies: 96
- Views: 292158
Re: ADCOM
I would never recommend thinking in absolutes re Geron. You may not consider the failure of FDA to approve. I could not conceive of Janssen rejecting a Geron partnership. Now I no longer think in terms of absolutes. I highly recommend it.
- Tue Oct 24, 2023 7:53 pm
- Forum: ImetelChat
- Topic: new article today
- Replies: 6
- Views: 2531
Re: new article today
Jay, I think Geron optimistically thought they would get priority review and not incur and extra 60 M while waiting. That puts a big dent in any projections to which have been subjected. It seems that every time we are reassured there is enough money to get to X time, they raise.