Search found 61 matches
- Mon Apr 29, 2019 10:12 pm
- Forum: ImetelChat
- Topic: What makes a CEO a CEO?
- Replies: 16
- Views: 9742
Re: What makes a CEO a CEO?
Smuggle: The compensation issue is an important consideration. Hunt: I chose to respond to your reaction mainly because of my ( perhaps naïve) hope that someone from Geron management will possibly read the present discourse and see an opportunity to saw the seeds for diverse input in the decision ma...
- Sat Apr 27, 2019 2:09 am
- Forum: ImetelChat
- Topic: What makes a CEO a CEO?
- Replies: 16
- Views: 9742
Re: What makes a CEO a CEO?
Cheng-ho: Unfortunately, competition issues and conservative stance by management (i.e., no emphasis on combos, leaving MF to be decided upon despite claims it prolongs life significantly, no long-term vision for Imetelstat, other?) has been depressing share price in the lower end of the penny stock...
- Sun Apr 07, 2019 8:21 pm
- Forum: ImetelChat
- Topic: Kmall - Global Update
- Replies: 5
- Views: 5122
Re: Kmall - Global Update
Greetings Kmall, Keep up the great work! Thank you very much.
- Thu Mar 28, 2019 10:52 pm
- Forum: ImetelChat
- Topic: Confirmation Bias, is there a way through it?
- Replies: 9
- Views: 5865
Re: Confirmation Bias, is there a way through it?
I agree about the pivotal importance of combo therapies for Geron’s success. Sadly, Geron management does not appear to be keen on such opportunity. I reread the transcript of the last CC to see if I missed anything of import. I was hard pressed to find any emphasis of a vision, well articulated mis...
- Sat Mar 23, 2019 11:18 pm
- Forum: ImetelChat
- Topic: EMA
- Replies: 5
- Views: 3698
Re: EMA
Respectfully, may I ask your opinion why would there be a chance of approval when in fact Phase 3 in MF is not even certain and remain to be decided.
- Sat Mar 23, 2019 8:01 pm
- Forum: ImetelChat
- Topic: Confirmation Bias, is there a way through it?
- Replies: 9
- Views: 5865
Re: Confirmation Bias, is there a way through it?
Cheng_ho: I couldn't agree with you more. Whenevr I raise the point that Tefferi/Mayo study and its patient population should have been replicated, folks seem to brush it off. Some say focus on the sickest of the patients was justified because there is no competition in that group. I believe there i...
- Sat Feb 23, 2019 10:06 pm
- Forum: ImetelChat
- Topic: The JNJ-ARGX deal in MDS/AML
- Replies: 1
- Views: 1983
Re: The JNJ-ARGX deal in MDS/AML
Argx drug targets high risk MDS whereas Imet targets intermediate-1 or low risk patient groups. However, phenomonal success of their drug in AML may be a significant threat to Geron's future attempt to widen the scope of treatment space to include AML.
- Fri Feb 22, 2019 6:31 pm
- Forum: ImetelChat
- Topic: Geron can continue to provide a key part of the equation
- Replies: 18
- Views: 19164
Re: Geron can continue to provide a key part of the equation
Anyone read "Good to Great" by James Collins et.al. ? In an emprical study they have identified characteristics of a great CEO , Level Five Leader they call it. Geron is facing significant challenges and to rise above these requires very competent and aggressive leadership who does not follow a poli...
- Sun Feb 03, 2019 4:55 am
- Forum: ImetelChat
- Topic: Parexcel is the CRO
- Replies: 4
- Views: 3695
Re: Parexcel is the CRO
What disaster? If your cost basis was near cash value then you wouldn't loose a cent on paper. There are many of us who had been mislead by Janssen before CD with cost basis over 5$. Yes, so far it has been a disaster for me. I hope tide will turn this year. I agree that bonuses are most likely nego...
- Sat Feb 02, 2019 7:32 pm
- Forum: ImetelChat
- Topic: Parexcel is the CRO
- Replies: 4
- Views: 3695
Re: Parexcel is the CRO
Compensation levels seem to be high for a stock that has been trading near its cash value. I understand that getting talent on board is a costly endevour. But, I would think there has to be some way to tie compensation to results. I wonder what was the rationale for Dr. Scarlett's bonus ( 280,000$) ...
- Sat Jan 26, 2019 8:14 pm
- Forum: ImetelChat
- Topic: Brainstorm thread for activist role
- Replies: 6
- Views: 4617
Re: Brainstorm thread for activist role
Biopearl, If we feel a need to write to Dr. Scarlett and the board in the future, it might be worthwhile to state our quantified aggregate stakes. At the present, I feel we are limited to exercise patience and allow time for complex challenges to unravel. The share price signals doom and gloom about...
- Wed Jan 23, 2019 10:55 pm
- Forum: ImetelChat
- Topic: Random musings on things I don’t understand
- Replies: 9
- Views: 6393
Re: Random musings on things I don’t understand
I think we longs tend to have thoughts that often reflect confirmation bias. Perhaps, there is value in playing devils advocate from time to time to put issues in a balanced and realistic perspective. Considering all of the facts that we know this far, I tend to think best we can hope in MF story is...
- Mon Jan 21, 2019 5:56 pm
- Forum: ImetelChat
- Topic: Random musings on things I don’t understand
- Replies: 9
- Views: 6393
Re: Random musings on things I don’t understand
Biopearl: I did not know that 7 patients remaining on the trial. As you said if the drug prolongs life significantly why has many patients dropped out? Is it possible that symptoms of the illness (that Imet does not treat well) were unberable as the reason for dropping out? Did the patients use anot...
- Sun Jan 13, 2019 10:56 pm
- Forum: ImetelChat
- Topic: Brainstorm thread for activist role
- Replies: 6
- Views: 4617
Brainstorm thread for activist role
To follow recommendation by Huntingonthebluffs, this thread is dedicated to discuss and compile important ideas, questions/concerns, and recommendations that could be forwarded to Dr. Scarlett and the board via the Geron IR. I believe, to be impactful, we need to focus on issues that comprise value ...
- Thu Jan 10, 2019 11:21 pm
- Forum: ImetelChat
- Topic: Best New Year Wishes to all from bp (123)
- Replies: 5
- Views: 4137
Re: Best New Year Wishes to all from bp (123)
Biopearl: Thank you for spelling out the likely outcomes which will make it a great year for us longs, as well as patients. These astute predictions imply a good bit of news flow in the course of the year toward increasingly higher share price as well. My take is JS is more inclined to sell the comp...
- Sat Jan 05, 2019 4:02 am
- Forum: ImetelChat
- Topic: Letter to Dr. Scarlett
- Replies: 23
- Views: 17368
Re: Letter to Dr. Scarlett
Received the below response today: Dear Errol, I realized that some additional context might be helpful regarding Geron’s policies and procedures related to corporate governance and investor relations as well as a proactive response to your questions. As you may know, Geron has more than 60,000 stoc...
- Fri Jan 04, 2019 2:39 am
- Forum: ImetelChat
- Topic: Letter to Dr. Scarlett
- Replies: 23
- Views: 17368
Re: Letter to Dr. Scarlett
Bp, I agree with your assesment and share the same concerns you have pointed out. Email flow re: letter to Scarlett and the Board of Directors: Hello, Thank you for your interest in Geron your feedback is appreciated. Your letter will be forwarded to the board, however, please note that it is not po...
- Fri Jan 04, 2019 12:05 am
- Forum: ImetelChat
- Topic: New FDA guidelines
- Replies: 2
- Views: 2590
Re: New FDA guidelines
I believe the use of control arm in the trial is going to work to our favor in talks with FDA.
Please see: ncbi.nlm.nih.gov
Please see: ncbi.nlm.nih.gov
- Sun Dec 30, 2018 8:35 pm
- Forum: ImetelChat
- Topic: Letter to Dr. Scarlett
- Replies: 23
- Views: 17368
Re: Letter to Dr. Scarlett
Bp, I did not know about the listing you mentioned at the time I drafted the letter. I think we have delved into the heart of those misleading actions via the compassionate use list and "job posting" in the letter. I am not holding my breath about receiving fact of the matter response from Dr. Scarl...
- Wed Dec 26, 2018 4:47 am
- Forum: ImetelChat
- Topic: Letter to Dr. Scarlett
- Replies: 23
- Views: 17368
Re: Letter to Dr. Scarlett
Here is the final draft which includes invaluable contributions by Huntingtonthebluffs and Biopearl. Hi Jacob, I would like to kindly ask you to forward the below letter to Dr. Scarlett and to the Board of Directors on behalf of I and a group of shareholders. Thank you! Errol Kara Dear Dr. Scarlett ...