Search found 202 matches
- Wed Apr 01, 2020 9:58 pm
- Forum: ImetelChat
- Topic: Telomerase
- Replies: 3
- Views: 2796
Re: Telomerase
I answered gwik on ST... the quick answer is yes, there are many other telomerase-inhibitor drugs already in use. Azacitidine is currently in many combo trials, including the ARGX trial that JNJ funded heavily right after dropping Geron. Also check out Constellation... just do searches on "MDS" and ...
- Thu Mar 26, 2020 3:59 pm
- Forum: ImetelChat
- Topic: Successful ABBV telomerase-inhibitor combo study in AML
- Replies: 0
- Views: 1803
Successful ABBV telomerase-inhibitor combo study in AML
So ABBV got good results in VERY sick AML patients,using azacitidine as their telomerase inhibitor along with Venclexta. Other companies are using the ancient 1990s telomerase inhibitors in trials as well, ARGX, Constellation, and many others. Why are these companies avoiding collaboration with Gero...
- Mon Mar 23, 2020 5:10 pm
- Forum: ImetelChat
- Topic: Since everyone is on lockdown....
- Replies: 1
- Views: 2909
Re: Since everyone is on lockdown....
Obviously the TERT promoter has to mutate in order to upregulate telomerase in cancer cells. What "Geron R&D" are you talking about? Did they build a lab somewhere? AFAIK they have an office in NJ that does CTPM for the trials, and an office in Menlo Park that pays the largest average salaries in CA...
- Fri Mar 13, 2020 10:32 pm
- Forum: ImetelChat
- Topic: Good Bye
- Replies: 4
- Views: 3150
Re: Good Bye
Good luck, kara. Check out those papers on NAD+ boosting and telomerase activation... there's still a chance for you to hang on until the real Age Of Biotech starts.
- Mon Mar 02, 2020 8:27 pm
- Forum: ImetelChat
- Topic: Perspective on the MF field
- Replies: 7
- Views: 5311
Re: Perspective on the MF field
Scarlett never addressed why JNJ was looking for a pricing manager for imetelstat for AML in addition to MDS and MF - that came out of nowhere - I would like to go to the shareholders meeting to ask him that question - was it a surprise to him or was he aware they were working on something? I am su...
- Mon Mar 02, 2020 4:41 pm
- Forum: ImetelChat
- Topic: FTSV acquisition by GILD
- Replies: 4
- Views: 4631
FTSV acquisition by GILD
Clearly, big pharma is interested in the MDS/AML market, they see it as large and effective therapy as attainable.
JNJ is invested in ARGX and Constellation, now GILD has bought out FSTV.
Any thoughts as to why no pharma has shown interest in Geron?
JNJ is invested in ARGX and Constellation, now GILD has bought out FSTV.
Any thoughts as to why no pharma has shown interest in Geron?
- Mon Mar 02, 2020 4:38 pm
- Forum: ImetelChat
- Topic: Perspective on the MF field
- Replies: 7
- Views: 5311
Re: Perspective on the MF field
i think they bailed due to the italian paper on MOS - when it came out there was no chance to refute it or prove it and thus they didn't feel comfortable in committing up to a billion dollars to continue - that killed the deal - the FDA must think there is something here to grant fast track after l...
- Tue Feb 25, 2020 4:49 pm
- Forum: ImetelChat
- Topic: Perspective on the MF field
- Replies: 7
- Views: 5311
Perspective on the MF field
MF is a lot smaller market... but there are still many current trials, some of them even combo trials.
https://clinicaltrials.gov/ct2/results? ... ity=&dist=
https://clinicaltrials.gov/ct2/results? ... ity=&dist=
- Mon Feb 24, 2020 10:45 pm
- Forum: ImetelChat
- Topic: Review paper on low-risk MDS, brief mention of imetelstat
- Replies: 0
- Views: 2686
Review paper on low-risk MDS, brief mention of imetelstat
A really severe condemnation of the whole plarma/patent/FDA system... no new drug for 13 years:
https://link.springer.com/article/10.10 ... 20-03963-1
https://link.springer.com/article/10.10 ... 20-03963-1
- Wed Feb 19, 2020 6:39 pm
- Forum: ImetelChat
- Topic: new Geron patent on 6-thio-dG and other Guanine variants
- Replies: 0
- Views: 2610
new Geron patent on 6-thio-dG and other Guanine variants
Geron received a patent on Guanine analogs as telomerase length affectors (e.g., 6-thio-dG). More confirmation that Dr. Shay is right and that 6-thio-dG is the future... does anyone here know how this affects the MAIA IP?
https://patents.justia.com/assignee/geron-corporation
https://patents.justia.com/assignee/geron-corporation
- Tue Feb 11, 2020 4:34 pm
- Forum: ImetelChat
- Topic: Perspective on the MDS field
- Replies: 0
- Views: 3123
- Mon Feb 10, 2020 4:01 pm
- Forum: ImetelChat
- Topic: Hat tip to hay flick YMB
- Replies: 4
- Views: 3372
Re: Hat tip to hay flick YMB
No, you were right, biopearl. Geron isn't doing genetic screening in the trials... and so far they've recruited only half the patients they need for the MDS trial, even just taking whatever victims Paraxel can find.
This is just a hope for the future. Maybe in a Phase 3 design for MF?
This is just a hope for the future. Maybe in a Phase 3 design for MF?
- Sun Feb 09, 2020 2:47 pm
- Forum: ImetelChat
- Topic: Targeting imet on genetic subtypes: hope for effectiveness?
- Replies: 0
- Views: 2879
Targeting imet on genetic subtypes: hope for effectiveness?
Just as Gleevec got its reputation because it is only used on genetic subtypes where it has a better chance, Imetelstat might be developed into an effective therapy if susceptible subtypes are found. (Caffeine is actually VERY effective on cancers with a certain DNA-repair defect...) Hayflick on the...
- Sun Feb 09, 2020 2:38 pm
- Forum: ImetelChat
- Topic: Avalanch of Classaction Lawsuits
- Replies: 1
- Views: 2548
Re: Avalanch of Classaction Lawsuits
Scarlett has settled past lawsuits without a fight. That's what attracts the lawyers... the last suit extracted more than $6 million, and all the firm had to do was file it. There is no Giant Short Conspiracy That Only Posts On YHOO Message Boards... no one has to pay lawyers or sharks to attack eas...
- Tue Feb 04, 2020 8:15 pm
- Forum: ImetelChat
- Topic: Imet Angels - A grassroots movement
- Replies: 4
- Views: 4760
Re: Imet Angels - A grassroots movement
Shears is obviously right... Rizo had already left for CELG, she knew that the imetelstat project was going to be dropped.
Might as well ask why the guy that GERN hired from ATNM came... they're just refugees.
Notice that JNJ kept Gryzanov... he's still valuable.
Might as well ask why the guy that GERN hired from ATNM came... they're just refugees.
Notice that JNJ kept Gryzanov... he's still valuable.
- Thu Jan 23, 2020 4:50 pm
- Forum: ImetelChat
- Topic: New Fool post
- Replies: 0
- Views: 3286
New Fool post
Still nothing from the real media since 2014, though.
https://www.fool.com/investing/2020/01/ ... ortfo.aspx
https://www.fool.com/investing/2020/01/ ... ortfo.aspx
- Mon Jan 20, 2020 6:24 pm
- Forum: ImetelChat
- Topic: New paper from Shay lab on 6-thio-dG
- Replies: 0
- Views: 2953
- Fri Dec 27, 2019 4:01 pm
- Forum: ImetelChat
- Topic: 14 months since Gernobyl
- Replies: 3
- Views: 3385
Re: 14 months since Gernobyl
Janssen was clearly concerned with MDS from the beginning: https://ir.geron.com/investors/press-releases/press-release-details/2014/Geron-Announces-Global-Strategic-Collaboration-with-Janssen--to-Develop-and-Commercialize-Imetelstat/default.aspx You can't un-GERNobyl a reactor, you have to build a b...
- Fri Dec 27, 2019 3:24 pm
- Forum: ImetelChat
- Topic: AGIO <--> GERN ....CoRelation?
- Replies: 2
- Views: 2660
Re: AGIO <--> GERN ....CoRelation?
The issue isn't number of patients, it's statistical power. If you get a high percentage of CRs in your 25 patients, that's a lot better than unclear results on a larger number.
That's how effective drugs get conditional approval straight out of Phase 1 and 2.
That's how effective drugs get conditional approval straight out of Phase 1 and 2.
- Thu Nov 21, 2019 4:08 pm
- Forum: ImetelChat
- Topic: The "other two" abstracts
- Replies: 1
- Views: 2669
Re: The "other two" abstracts
Any lab can make imetelstat with their in-house oligo synthesizer, and then do the chemical step to add the lipid tail. Geron can't stop people from researching imetelstat.